Plant Name: Pachygone dasycarpa
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| FFAR1; FFAR4; | |
| GAA; | |
| FAAH; TDP1; TERT; CBR1; AKR1B1; HSD17B10; ALOX15; ALDH1A1; | |
| CDK6; | |
| CA2; CA1; CA12; CA9; CA14; CA7; CA4; CA6; | |
| PPARA; PPARD; PPARG; | |
| NR1I2; | |
| PTGS1; XDH; | |
| HIF1A; | |
| ABCG2; | |
| NPC1; FABP5; MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | CBR1 | Carbonyl reductase [NADPH] 1 | P16152 | CHEMBL5586 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Showing 1 to 10 of 38 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 5.086E-13 | 7.911E-10 | CA1, CA12, CA2, CA4, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 5.608E-12 | 6.784E-09 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.757E-11 | 1.822E-08 | CYP1A2, CYP2C19, CYP2C9, CYP3A4, NR1I2 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.904E-10 | 1.337E-07 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.458E-10 | 2.773E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0034754; cellular hormone metabolic process | 6.339E-08 | 2.654E-05 | AKR1B1, ALDH1A1, CYP19A1, CYP1A1, CYP1B1, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.527E-06 | 4.817E-04 | CYP1A2, CYP2C9, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 2.941E-06 | 8.420E-04 | CYP19A1, FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0050896; response to stimulus | GO:0033189; response to vitamin A | 4.686E-06 | 1.308E-03 | CYP1A1, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 1.129E-05 | 2.859E-03 | CA2, CA7 |
Showing 1 to 10 of 32 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.479E-03 | 6.262E-03 | GAA; AKR1B1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 8.022E-08 | 9.626E-07 | CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.503E-05 | 2.293E-04 | CYP1A2; XDH |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 5.956E-05 | 3.299E-04 | CYP1A2; CYP1A1; CYP1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.127E-07 | 1.159E-06 | CYP2C9; CBR1; ALOX15; CYP2C19; PTGS1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.164E-09 | 5.193E-08 | CYP2C9; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.432E-07 | 1.289E-06 | CYP2C9; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.853E-18 | 1.334E-16 | CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 4.826E-09 | 8.686E-08 | CYP2C9; CBR1; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 8.764E-06 | 6.310E-05 | CYP2C9; CYP1A2; CYP3A4; CYP2C19 |
Showing 1 to 10 of 19 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Melanoma | C43 | TERT |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; TERT |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTGS1; FAAH |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT |
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1; CA9; TERT |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
Showing 1 to 10 of 79 entries