Plant Name: Chloranthus tianmushanensis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; FFAR1; FFAR4; | |
| TSHR; OPRD1; | |
| FAAH; TDP1; TERT; HPGD; ALOX15; ALDH1A1; USP2; UBE2N; | |
| TRPA1; | |
| MAPK1; | |
| CA12; CA13; CA1; CA9; CA7; | |
| PPARA; PPARD; PPARG; | |
| THRB; | |
| NR1I2; | |
| PTGS1; | |
| TLR2; | |
| HIF1A; | |
| ABCB1; ABCG2; | |
| SLCO1B1; SLCO1B3; | |
| NPC1; RAB9A; LMNA; FABP3; FABP5; FABP4; MAPT; FABP2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Showing 1 to 10 of 42 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.363E-08 | 1.855E-05 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.876E-08 | 4.964E-05 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 2.362E-07 | 1.774E-04 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 1.135E-06 | 5.884E-04 | ABCB1, ABCG2, NR1I2 |
| BP | GO:0007610; behavior | GO:0007610; behavior | 1.911E-06 | 8.160E-04 | HIF1A, MAPK1, MAPT, NPC1, OPRD1, PPARA, THRB, TLR2, USP2 |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 2.031E-06 | 8.506E-04 | NR1I2, PPARA, PPARD, PPARG, THRB, UBE2N |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 2.982E-06 | 1.142E-03 | HIF1A, LMNA, OPRD1, PPARD, TERT |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 4.890E-06 | 1.690E-03 | CYP19A1, FFAR4, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 8.904E-06 | 2.938E-03 | NR1I2, PPARA, PPARD, PPARG, THRB |
| BP | GO:0065007; biological regulation | GO:0010817; regulation of hormone levels | 1.180E-05 | 3.671E-03 | ALDH1A1, CYP19A1, CYP3A4, FFAR1, FFAR4, HIF1A, PPARD, SLCO1B1 |
Showing 1 to 10 of 22 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.686E-03 | 2.945E-02 | ALOX15; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.939E-10 | 1.260E-08 | CA12; CA1; CA7; CA9; CA13 |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 3.851E-03 | 4.552E-02 | ABCB1; ABCG2 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.043E-10 | 1.260E-08 | FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 2.039E-03 | 2.945E-02 | OPRD1; ADORA3; MAPK1 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.665E-03 | 3.464E-02 | OPRD1; THRB; ADORA3; TSHR |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.674E-03 | 2.945E-02 | ALOX15; MAPK1; PTGS1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.943E-03 | 2.945E-02 | THRB; MAPK1; HIF1A |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 2.209E-04 | 7.180E-03 | FABP4; TSHR; PTGS1 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 3.753E-07 | 1.626E-05 | SLCO1B1; ABCB1; SLCO1B3; CYP3A4; ABCG2 |
Showing 1 to 10 of 11 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3 |
| C00-D49: Neoplasms | Multiple myeloma | C90 | TERT |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1; CA9; TERT |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TERT |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Cancer | C00-C96 | ABCB1; ADORA3; HIF1A; CA1; CA9; MAPK1; TLR2 |
Showing 1 to 10 of 99 entries