CMAUP Plant Collective Molecular Activities

Plant Name: Uvaria klaineana

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.180E-13	7.910E-10	CA1, CA12, CA2, CA4, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.650E-09	1.316E-05	CA1, CA12, CA2, CA4, CA6, CA7, CA9, NR1H4, PPARA, PPARD, PPARG, PTPN1
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.242E-08	3.756E-05	NR1H4, PPARA, PPARD, PPARG, STAT3
BP	GO:0065007; biological regulation	GO:0042593; glucose homeostasis	3.146E-07	2.864E-04	FFAR1, NR1H4, PPARG, PTPN11, PTPN2, STAT3
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	6.975E-07	4.340E-04	CES1, CES2, PLA2G1B, PPARA, PPARD, PPARG, PTGES
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.899E-07	4.778E-04	CDC25B, PTPN1, PTPN11, PTPN2, PTPN6
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	1.239E-06	6.916E-04	PTPN1, PTPN11, PTPN2, PTPN6
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.661E-06	8.413E-04	NR1H4, PPARA, PPARD, PPARG, PTPN2
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	3.007E-06	1.364E-03	PTPN11, PTPN6
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	3.399E-06	1.424E-03	NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	5.668E-06	2.204E-03	PLA2G1B, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	6.174E-06	2.318E-03	AKR1B1, APAF1, CA2, CA9, MAPT, POLB, PPARD, PPARG, PTPN1, PTPN11, TDP1, TERT
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	9.012E-06	3.102E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	9.012E-06	3.102E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	9.012E-06	3.102E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	9.012E-06	3.102E-03	CES1, CES2
BP	GO:0050896; response to stimulus	GO:0070482; response to oxygen levels	1.047E-05	3.455E-03	APAF1, POLB, PPARA, PPARD, PPARG, TERT
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	1.296E-05	4.151E-03	NR1H4, PPARA, PPARD, PPARG, STAT3
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	1.471E-05	4.556E-03	AKR1B1, CA2, CA9, PLA2G1B, PPARA, PPARG, STAT3, TSHR
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.800E-05	5.298E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0071495; cellular response to endogenous stimulus	1.904E-05	5.455E-03	AKR1B1, APAF1, NR1H4, PLA2G1B, PPARG, PTPN11, STAT3, TSHR
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	2.997E-05	8.158E-03	PPARA, PPARG
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.414E-19	5.257E-15	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.422E-15	4.661E-11	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	6.889E-19	5.925E-17	CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14
hsa04931	Insulin resistance_Homo sapiens_hsa04931	3.413E-05	9.783E-04	PTPN1; STAT3; PTPN11; PPARA
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.766E-05	7.594E-04	AKR1B10; GAA; AKR1B1
hsa04630	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.446E-04	3.108E-03	STAT3; PTPN6; PTPN11; PTPN2
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	2.273E-04	3.258E-03	STAT3; PTPN11; PPARA
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.178E-04	3.258E-03	PPARG; PPARA; PPARD
hsa00040	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.704E-03	1.629E-02	AKR1B10; AKR1B1
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	4.891E-03	3.057E-02	STAT3; PTPN6; PTPN11
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	4.222E-03	3.057E-02	STAT3; PPARD
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	6.940E-04	8.526E-03	CA2; CA4
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.770E-03	2.383E-02	CES2; CES1
hsa00561	Glycerolipid metabolism_Homo sapiens_hsa00561	4.517E-03	3.057E-02	AKR1B10; AKR1B1
hsa00051	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.348E-03	1.449E-02	AKR1B10; AKR1B1
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	4.976E-03	3.057E-02	PLA2G1B; PTGES
hsa04520	Adherens junction_Homo sapiens_hsa04520	7.018E-03	3.772E-02	PTPN1; PTPN6
hsa04976	Bile secretion_Homo sapiens_hsa04976	6.477E-03	3.714E-02	CA2; NR1H4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; FFAR1; AKR1B1; PPARG
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD; PPARG
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; FFAR1; PPARD; PPARG; PPARG
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; ACHE; STAT3; CDC25B
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
C00-D49: Neoplasms	Prostate cancer	C61	TERT
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B; CES1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; MAPT
C00-D49: Neoplasms	Renal cancer	C64	CA9
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	CES1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B; AKR1B1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD; PPARG
C00-D49: Neoplasms	Multiple myeloma	C90	TERT; STAT3
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ACHE; ACHE; PTGES; MAPT; PPARG; PPARG
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PPARG
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; STAT3
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; ACHE; CA4
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT; PPARG
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
C00-D49: Neoplasms	Ovarian cancer	C56	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CES1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	CES1
C00-D49: Neoplasms	Melanoma	C43	TERT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; PPARD; PPARD; PPARG
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
C00-D49: Neoplasms	Liver cancer	C22	TERT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD; MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1; TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	CES1; PPARD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	CES1; PPARD
NA: NA	Dyslipidemia	NA	PPARD
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; AKR1B1; ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1; PPARG
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	STAT3
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
C00-D49: Neoplasms	Breast cancer	C50	CA9; TERT

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases