Plant Name: Millettia brandisiana
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.809E-08 | 3.940E-04 | CYP19A1, CYP1B1, CYP2C19, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.078E-07 | 1.174E-03 | CA12, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 6.153E-07 | 1.384E-03 | CYP19A1, CYP1B1, CYP2C19, CYP3A4, GAA, HSD17B1, HSD17B10 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 4.185E-07 | 1.384E-03 | CYP19A1, CYP1B1, CYP3A4 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.256E-06 | 2.486E-03 | CYP19A1, CYP1B1, CYP2C19, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.408E-06 | 2.555E-03 | CYP19A1, CYP2C19, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.679E-06 | 2.638E-03 | CA12, CA4, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.104E-06 | 3.755E-03 | CA12, CA4, CA7 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 3.059E-06 | 3.755E-03 | CYP19A1, CYP1B1, CYP2C19, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 6.262E-06 | 6.126E-03 | CYP2C19, CYP3A4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 4.464E-08 | 3.259E-06 | HSD17B1; CYP1B1; CYP3A4; CYP19A1 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 4.131E-06 | 7.745E-05 | HSD17B1; CYP1B1; CYP19A1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 4.244E-06 | 7.745E-05 | GAA; HSD17B1; ALPL; CYP2C19; CYP3A4; CYP19A1; HSD17B10 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.451E-07 | 5.297E-06 | CA12; CA4; CA7 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.844E-05 | 2.693E-04 | CYP1B1; CYP3A4; CYP2C19 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.568E-04 | 1.908E-03 | CYP3A4; CYP2C19 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 8.928E-04 | 9.113E-03 | CYP3A4; CYP2C19 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 9.986E-04 | 9.113E-03 | CYP1B1; CYP3A4 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1 |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1 |