GPR35; DRD4; | |
TAS2R31; | |
TSHR; NPSR1; CXCR1; | |
RECQL; PLA2G1B; TDP1; BLM; APOBEC3G; CTDSP1; PKM; PIK3CG; PIK3R1; GLO1; HPGD; MPO; HSD17B1; CBR1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; NOX4; USP2; TNKS; PARP1; TNKS2; PYGL; APEX1; POLB; CD38; | |
ACHE; | |
CFTR; | |
TOP2A; | |
AKT1; MET; CAMK2B; INSR; CSNK2A1; DAPK1; SYK; NEK2; FLT3; MYLK; SRC; IGF1R; PTK2; AURKB; GSK3B; CDK6; CDK1; PIM1; NUAK1; ALK; AXL; NEK6; KDR; PKN1; | |
CA12; CA14; CA5A; CA3; CA7; CA1; CA9; CA4; CA6; CA2; | |
AR; | |
ESRRA; | |
PPARA; | |
ESR1; ESR2; | |
KDM4E; | |
MAOA; ALDH2; ALOX5; PTGS2; TYR; XDH; | |
MMP13; MMP12; MMP3; MMP2; MMP9; | |
BACE1; | |
AHR; STAT6; HIF1A; NFKB1; TP53; | |
ABCC1; ABCG2; | |
LMNA; MAPT; THPO; RAB9A; NPC1; APP; TTR; | |
L3MBTL1; SMN1;SMN2; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
Chloride channel | CFTR | Cystic fibrosis transmembrane conductance regulator | P13569 | CHEMBL4051 |
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 6.090E-13 | 2.072E-10 | CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.477E-12 | 2.006E-09 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.276E-11 | 8.953E-09 | CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
BP | Unclassified; | GO:0032844; regulation of homeostatic process | 4.796E-10 | 8.288E-08 | AURKB, CA2, CA7, CD38, CDK6, CFTR, HIF1A, KDR, NEK2, NPC1, NPSR1, PARP1, PLA2G1B, PTGS2, SRC, SYK, TNKS, TNKS2 |
BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 1.036E-09 | 1.684E-07 | AURKB, CA2, CA7, CFTR, HIF1A, NEK2, NPC1, NPSR1, PLA2G1B, PTGS2, SYK, TNKS, TNKS2 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 2.076E-09 | 3.088E-07 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 5.484E-09 | 7.607E-07 | CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4 |
BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 5.484E-09 | 7.607E-07 | CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4 |
BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 2.967E-08 | 3.347E-06 | ALOX12, ALOX15, ALOX5, HPGD, PTGS2 |
BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 5.895E-08 | 6.201E-06 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, NEK6, PKN1, SRC, SYK, TNKS |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|
hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.848E-02 | 3.177E-02 | ALDH2; AKR1B1 |
hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 4.331E-08 | 6.063E-07 | HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.297E-04 | 9.102E-04 | CYP1A2; XDH |
hsa00340 | Histidine metabolism_Homo sapiens_hsa00340 | 8.469E-03 | 1.551E-02 | ALDH2; MAOA |
hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.752E-02 | 3.050E-02 | MAOA; TYR |
hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 3.367E-06 | 1.737E-05 | ALDH2; MAOA; CYP1A2; CYP1A1; CYP1B1 |
hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 8.502E-11 | 4.166E-09 | CYP2C9; CBR1; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS2 |
hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.582E-10 | 8.435E-09 | CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
hsa00620 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.606E-03 | 3.578E-03 | PKM; ALDH2; GLO1 |
hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.089E-06 | 1.137E-05 | CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
---|---|---|---|
A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
A00-B99: Certain infectious and parasitic diseases | Diarrhea | A09, K59.1 | CFTR |
A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
A00-B99: Certain infectious and parasitic diseases | HIV-associated diarrhoea | A09 | CFTR |
A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | PIK3CG; CYP2C9 |