CMAUP Plant Collective Molecular Activities

Plant Name: Euryale ferox

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	1.977E-08	8.612E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	4.741E-08	1.475E-04	ADORA1, ADORA2A, ADORA3
CC	GO:0044464; cell part	GO:0030673; axolemma	3.148E-07	8.570E-04	ADORA1, ADORA2A, MAPT
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	7.290E-07	1.221E-03	SLC28A2, SLC28A3
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	7.290E-07	1.221E-03	SLC28A1, SLC28A3
MF	GO:0005215; transporter activity	GO:0015211; purine nucleoside transmembrane transporter activity	7.290E-07	1.221E-03	SLC28A2, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	2.186E-06	2.380E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	2.186E-06	2.380E-03	SLC28A1, SLC28A3
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	2.186E-06	2.380E-03	ADORA1, ADORA2A
BP	GO:0032501; multicellular organismal process	GO:0007399; nervous system development	6.751E-06	5.880E-03	ACHE, ADORA1, GDA, SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	6.885E-04	1.928E-02	CDA; TK1
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.548E-03	2.167E-02	ADORA2A; ADORA3; ADORA1
hsa00240	Pyrimidine metabolism_Homo sapiens_hsa00240	3.527E-03	3.204E-02	CDA; TK1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	4.578E-03	3.204E-02	ADORA3; ADORA1
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	8.681E-03	3.841E-02	ADORA3; ADORA1
hsa03013	RNA transport_Homo sapiens_hsa03013	9.187E-03	3.841E-02	SMN2; SMN1
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	1.214E-02	4.250E-02	ADORA2A; ADORA1
hsa00230	Purine metabolism_Homo sapiens_hsa00230	9.602E-03	3.841E-02	GDA; ADK

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TK1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT; ACHE; ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA2A; ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3; ADORA2A; ACHE; ADORA1
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1; ADORA1
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3
C00-D49: Neoplasms	Brain cancer	C71, D33	TK1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA2A; ADORA1
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1
C00-D49: Neoplasms	Cancer	C00-C96	TK1; ADORA3; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; ACHE; ACHE; ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA2A; ADORA1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1; ADORA1
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK; ACHE
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK
C00-D49: Neoplasms	Solid tumours	C00-D48	TK1; CDA
NA: NA	Hepatitis C virus infection	NA	ADORA3
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A
C00-D49: Neoplasms	Prostate cancer	C61	TK1
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT; ACHE
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1
NA: NA	Upper abdominal bloating	NA	ACHE
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
C00-D49: Neoplasms	Pancreatic cancer	C25	TK1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADORA2A; ADK; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA2A; ACHE; ADORA1
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Graft-versus-host disease	T86.0	TK1
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases