CMAUP Plant Collective Molecular Activities

Plant Name: Helleborus caucasicus

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.569E-10	6.064E-06	CA1, CA12, CA2, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.376E-08	7.392E-05	CA1, CA12, CA2, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.453E-08	1.484E-04	CA1, CA12, CA2, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.650E-07	3.266E-04	AR, CA1, CA12, CA2, CA9, PARP1, TNKS, TP53
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.919E-07	1.440E-03	CYP19A1, CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0003950; NAD+ ADP-ribosyltransferase activity	1.454E-06	1.583E-03	PARP1, TNKS, TNKS2
BP	GO:0065007; biological regulation	GO:1904357; negative regulation of telomere maintenance via telomere lengthening	1.635E-06	1.695E-03	PARP1, TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	4.370E-06	3.172E-03	TNKS, TNKS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.370E-06	3.172E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.853E-06	5.344E-03	CYP19A1, CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.921E-06	6.209E-03	ALOX15, CYP19A1, CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0070212; protein poly-ADP-ribosylation	1.091E-05	6.254E-03	PARP1, TNKS
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.091E-05	6.254E-03	ALOX15, HPGD
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.091E-05	6.254E-03	CA1, CA2
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.035E-05	9.847E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	8.442E-10	4.981E-08	CA12; CA1; CA2; CA9
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.529E-05	4.511E-04	CYP1A2; CYP1A1; CYP19A1
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	5.204E-04	7.677E-03	CYP1A2; CYP1A1
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.724E-04	5.357E-03	CYP1A2; ALOX15
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	8.133E-04	9.597E-03	CYP1A1; CYP19A1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.371E-03	1.348E-02	CYP1A2; CYP1A1
hsa05215	Prostate cancer_Homo sapiens_hsa05215	2.550E-03	1.671E-02	AR; TP53
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.725E-03	1.454E-02	CYP1A2; CYP1A1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	2.170E-03	1.600E-02	CYP1A2; CYP1A1
hsa04210	Apoptosis_Homo sapiens_hsa04210	6.176E-03	3.037E-02	PARP1; TP53
hsa05162	Measles_Homo sapiens_hsa05162	5.839E-03	3.037E-02	RAB9A; TP53
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.002E-02	4.549E-02	HPGD; TP53
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	4.243E-03	2.503E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	AR
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	AR
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
G00-G99: Diseases of the nervous system G00-G99	Permanent and transient stroke	G45.9, I61-I63	PARP1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	AR; AR
G00-G99: Diseases of the nervous system G00-G99	Brain ischaemia	G45.9, I67.8	PARP1
C00-D49: Neoplasms	Female androgenresponsive recurrent mammary cancer	C50	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Testosterone deficiency	E29.1	AR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	AR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle atrophy	M62.5	AR
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; CA9
C00-D49: Neoplasms	Castration-resistant prostate cancer	C61	AR
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	AR
C00-D49: Neoplasms	Breast cancer	C50	CA9; CYP19A1; AR
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1
C00-D49: Neoplasms	Ovarian cancer	C56	PARP1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	AR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis in post-menopausal women	M80-M81	AR
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	PARP1
C00-D49: Neoplasms	Renal cancer	C64	CA9
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Cancer	C00-C96	CA1; TP53; CA9; AR; PARP1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	AR
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	PARP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Recurrent epithelial ovarian or primary peritoneal cancer	C78	PARP1
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	AR
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
I00-I99: Diseases of the circulatory system	Cerebrovascular disorders	I60-I69	PARP1
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	PARP1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
C00-D49: Neoplasms	Prostate cancer	C61	AR; AR
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory skin condition	L00-L99	PARP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	AR
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	AR
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1; AR
C00-D49: Neoplasms	Advanced prostate cancer	C61	AR
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	AR
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
C00-D49: Neoplasms	Melanoma	C43	PARP1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
NA: NA	Male hypogonadism	NA	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Male hormonal deficiencies	E20-E35	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	AR
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	AR
C00-D49: Neoplasms	Metastatic prostate cancer	C61	AR
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
I00-I99: Diseases of the circulatory system	Heart failure	I50	AR
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
L00-L99: Diseases of the skin and subcutaneous tissue	Alopecia	L65.9	AR
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
K00-K95: Diseases of the digestive system	Alcoholic hepatitis	K70.1	AR

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases