CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.930E-11	1.073E-06	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.116E-09	1.536E-05	CA12, CA2, CA4, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.868E-09	2.650E-05	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	7.235E-07	1.969E-03	CA2, CA7
BP	GO:0065007; biological regulation	GO:0042592; homeostatic process	8.563E-07	2.072E-03	AKR1B1, APP, CA12, CA2, CA7, GAA, POLB

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1
NA: NA	Geographic retinal atrophy	NA	APP
C00-D49: Neoplasms	Glioma	C71	APP
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	APP
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
C00-D49: Neoplasms	Cancer	C00-C96	APP
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
NA: NA	Edema	NA	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	APP
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	APP

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Aster koraiensis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases