CMAUP Plant Collective Molecular Activities

Plant Name: Alnus alnobetula

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	1.072E-11	2.594E-08	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.532E-08	6.167E-05	CYP1A1, CYP1A2, CYP1B1
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	4.075E-07	5.220E-04	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	4.997E-07	6.045E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	6.647E-07	6.893E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.647E-07	6.893E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0004435; phosphatidylinositol phospholipase C activity	1.096E-06	9.455E-04	CHRM1, CHRM3, CHRM5
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.374E-06	2.099E-03	CYP1A1, CYP1A2
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.272E-06	2.943E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0032501; multicellular organismal process	GO:0046541; saliva secretion	5.621E-06	3.060E-03	CHRM1, CHRM3
CC	GO:0044456; synapse part	GO:0043679; axon terminus	9.701E-06	4.694E-03	CHRM1, CHRM2, CHRM3
BP	GO:0008152; metabolic process	GO:0033013; tetrapyrrole metabolic process	1.081E-05	5.117E-03	ABCC1, CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.572E-05	6.864E-03	CYP1A1, CYP1A2
CC	GO:0045202; synapse	GO:0032279; asymmetric synapse	1.572E-05	6.864E-03	CHRM2, CHRM3
BP	Unclassified;	GO:0003056; regulation of vascular smooth muscle contraction	2.020E-05	7.997E-03	CHRM1, CHRM3
MF	Unclassified;	GO:0099600; transmembrane receptor activity	1.946E-05	7.997E-03	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, TAAR1, TSHR
BP	GO:0032501; multicellular organismal process	GO:0090257; regulation of muscle system process	2.330E-05	8.989E-03	CHRM1, CHRM2, CHRM3, LMNA
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	1.341E-16	1.460E-12	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	1.341E-16	1.460E-12	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	8.042E-16	5.837E-12	CHRM1, CHRM2, CHRM3, CHRM4, CHRM5

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	5.305E-10	1.857E-08	CHRM2; CHRM3; CHRM1; CHRM4; CHRM5; TAAR1; TSHR
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	1.381E-08	2.418E-07	CHRM2; CHRM3; CHRM1; CHRM4; CHRM5
hsa04810	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	3.684E-07	4.298E-06	CHRM2; CHRM3; CHRM1; CHRM4; CHRM5
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	3.316E-06	2.902E-05	CYP1A2; CYP1A1; CYP1B1
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	8.016E-06	5.611E-05	CHRM2; CHRM3; CHRM1; CHRM5
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.027E-05	5.993E-05	CYP1A2; CYP1A1; CYP1B1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.057E-05	1.028E-04	CYP1A2; CYP1A1; CYP1B1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	2.917E-05	1.276E-04	CYP1A2; CYP1A1; CYP1B1
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	4.042E-04	1.572E-03	CHRM2; CHRM1; TSHR
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	6.299E-04	2.205E-03	CYP1A1; CYP1B1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.063E-03	3.381E-03	CYP1A2; CYP1A1
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	2.031E-02	4.711E-02	ABCC1; CYP1B1
hsa04977	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.786E-02	4.711E-02	ABCC1
hsa00760	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.154E-02	4.711E-02	NT5E
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.154E-02	4.711E-02	CYP1A2
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	3.745E-03	1.092E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1
NA: NA	Uveitis	NA	CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	CHRM1; CHRM5
J00-J99: Diseases of the respiratory system	Asthma	J45	CHRM2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ABCC1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	CHRM1; CHRM3; CHRM4; CHRM5
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM4; CHRM5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRM3
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5
NA: NA	Suprapubic pain	NA	CHRM4
NA: NA	Addiction	NA	CHRM2
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
NA: NA	Peptic ulcer disease	NA	CHRM4
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	CHRM4
NA: NA	Gastritis	NA	CHRM4
NA: NA	Abdominal stomach pain	NA	CHRM1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	CHRM4
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	ABCC1; ABCC1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CHRM1; CHRM3; CHRM4
C00-D49: Neoplasms	Solid tumours	C00-D48	CHRM4
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2; CHRM4; CHRM4; CHRM4
K00-K95: Diseases of the digestive system	Pancreatitis	K85, K86.0K86.1	CHRM4
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRM1; CHRM1; CHRM2; CHRM4
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1
NA: NA	Excessive sweating	NA	CHRM1
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	CHRM4; CHRM4
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3; CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	CHRM4
I00-I99: Diseases of the circulatory system	Heart failure	I50	CHRM2
H00-H59: Diseases of the eye and adnexa	Acquired nystagmus	H55	CHRM4
S00-T88: Injury, poisoning and certain other consequences of external causes	Organophosphate poisoning	T60.0	CHRM4
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRM1; CHRM2; CHRM3; CHRM4
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM1; CHRM4; CHRM4; CHRM5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	CHRM4; CHRM4
NA: NA	Spasms	NA	CHRM3
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CHRM1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	CHRM1; CHRM5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nocturia	R35	CHRM4
NA: NA	Functional bowel syndrome	NA	CHRM1
NA: NA	Schizoaffective disorders	NA	CHRM1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5
NA: NA	Dystonia	NA	CHRM1
NA: NA	Dysuria	NA	CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2; CHRM4
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM1; CHRM1; CHRM5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	CHRM4
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	CHRM5
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	CHRM2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Urinary retention	R33	CHRM4
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5
NA: NA	Urgency	NA	CHRM4
J00-J99: Diseases of the respiratory system	Bronchodilator	J45	CHRM4
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3
NA: NA	Moderate and severe psychomotor agitation	NA	CHRM4
H00-H59: Diseases of the eye and adnexa	Mydriasis diagnosis	H57.0	CHRM4
NA: NA	Vomiting	NA	CHRM4
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5
H00-H59: Diseases of the eye and adnexa	Produce mydriasis and cycloplegia for diagnostic purposes	H57.04	CHRM4
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases