CMAUP Plant Collective Molecular Activities

Plant Name: Helenium quadridentatum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.157E-08	2.100E-05	ADRA2A, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.556E-06	3.092E-03	CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9, NR1H4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.989E-06	7.247E-03	CA2, CA7
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	6.989E-06	7.247E-03	ADRA2A, ADRA2C
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	7.600E-06	7.522E-03	CASP1, CASP7, MAPT, XDH
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	1.018E-05	9.639E-03	ACHE, ADRA2A, ADRA2C, ALDH1A1, HIF1A, NR1H4, SLCO1B1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	6.914E-23	1.506E-18	CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.519E-18	8.553E-14	CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.587E-16	1.562E-12	CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	2.451E-22	2.892E-20	CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14; CA13
hsa04976	Bile secretion_Homo sapiens_hsa04976	3.726E-06	2.198E-04	SLCO1B1; CA2; SLCO1B3; NR1H4
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	1.110E-04	3.275E-03	CASP7; MAPK1; MAPT; HSD17B10
hsa05133	Pertussis_Homo sapiens_hsa05133	1.912E-04	4.512E-03	CASP7; CASP1; MAPK1
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.967E-03	2.901E-02	MAPK1; ADRA2C; ADRA2A
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	2.169E-05	8.531E-04	CYP1A2; XDH
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	5.396E-04	1.061E-02	CA2; CA4
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	8.611E-04	1.452E-02	CYP1A2; ALOX15
hsa05134	Legionellosis_Homo sapiens_hsa05134	3.074E-03	3.815E-02	CASP7; CASP1
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	3.647E-03	3.815E-02	MAPK1; HIF1A
hsa04621	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	3.298E-03	3.815E-02	CASP1; MAPK1
hsa05211	Renal cell carcinoma_Homo sapiens_hsa05211	4.396E-03	3.815E-02	MAPK1; HIF1A
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	4.266E-03	3.815E-02	CYP1A2; ALDH1A1
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	4.527E-03	3.815E-02	MAPK1; HIF1A

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	XDH
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; ADRA2C; ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; CA9; MAPK1
I00-I99: Diseases of the circulatory system	Heart failure	I50	XDH; ADRA2C
C00-D49: Neoplasms	Breast cancer	C50	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE; MAPT
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CA1; CA9; MAPK1; ACHE
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; MAPT
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	CASP1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricemia	E79.0	XDH
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperuricaemia in gout	E79.0, M10	XDH
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	CASP1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C; CA4; CA4
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; ACHE; CA4
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
NA: NA	Upper abdominal bloating	NA	ACHE
G00-G99: Diseases of the nervous system G00-G99	Encephalopathy	G93.4	XDH
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; ADRA2A; ACHE
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C
C00-D49: Neoplasms	Renal cancer	C64	CA9
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases