CMAUP Plant Collective Molecular Activities

Plant Name: Clematis tangutica

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.484E-09	7.587E-05	CA12, CA2, CA4, CA7
MF	GO:0003824; catalytic activity	GO:0004556; alpha-amylase activity	2.161E-08	1.176E-04	AMY1A, AMY1B, AMY1C
MF	Unclassified;	GO:0103025; alpha-amylase activity (releasing maltohexaose)	2.161E-08	1.176E-04	AMY1A, AMY1B, AMY1C
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.475E-07	4.588E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.929E-07	5.250E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.375E-07	7.348E-04	CA12, CA2, CA4, CA7
BP	GO:0032501; multicellular organismal process	GO:0007586; digestion	2.783E-06	4.329E-03	AKR1B10, AMY1A, AMY1B, AMY1C
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	5.222E-06	5.415E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	5.222E-06	5.415E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	5.222E-06	5.415E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.044E-05	9.377E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0008152; metabolic process	1.077E-05	9.377E-03	ACP1, AKR1B10, AMY1A, AMY1B, AMY1C, BACE1, CA12, CA2, CA4, CA7, CDC25B, F10, FUT7, GFER, HSD11B1, NR1H4, PLA2G1B, POLB, PTPN1, PTPN2, PTPRF, RECQL, RORC, TDP1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	5.278E-09	2.481E-07	CA12; CA2; CA4; CA7
hsa00500	Starch and sucrose metabolism_Homo sapiens_hsa00500	5.165E-05	8.091E-04	AMY1A; AMY1B; AMY1C
hsa04973	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.669E-05	6.272E-04	AMY1A; AMY1B; AMY1C
hsa04520	Adherens junction_Homo sapiens_hsa04520	1.189E-04	1.397E-03	PTPN1; ACP1; PTPRF
hsa04970	Salivary secretion_Homo sapiens_hsa04970	2.057E-04	1.933E-03	AMY1A; AMY1B; AMY1C
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	7.979E-04	5.358E-03	HSD11B1; FUT7; AKR1B10; PLA2G1B; AMY1A; AMY1B; AMY1C
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	4.043E-04	3.167E-03	CA2; CA4
hsa04976	Bile secretion_Homo sapiens_hsa04976	3.822E-03	2.245E-02	CA2; NR1H4
hsa04931	Insulin resistance_Homo sapiens_hsa04931	8.783E-03	4.128E-02	PTPN1; PTPRF
hsa04972	Pancreatic secretion_Homo sapiens_hsa04972	6.875E-03	3.590E-02	CA2; PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	F10
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	F10
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F10
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1; CA4; CA4
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hematology	D50-D77	F10
I00-I99: Diseases of the circulatory system	Deep venous clots	I80.2	F10
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	F10
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
NA: NA	Christmas disease	NA	F10
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	F10
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Hemophilia	D66-D68	F10
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
I00-I99: Diseases of the circulatory system	Coagulation	I80-I82	F10
I00-I99: Diseases of the circulatory system	Prophylaxis of deep vein thrombosis	I80-I82, I80.2	F10
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
C00-D49: Neoplasms	Renal cancer	C64	F10
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
NA: NA	Haemophilia B	NA	F10
NA: NA	Edema	NA	CA2
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Blood coagulation disorders	D65-D68	F10
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1
I00-I99: Diseases of the circulatory system	Thromboembolic disorders	I80-I82	F10
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	F10
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	F10
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	F10
I00-I99: Diseases of the circulatory system	Deep vein thrombosis	I80-I82, I80.2	F10
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
I00-I99: Diseases of the circulatory system	Venous thromboembolism	I80-I82	F10
I00-I99: Diseases of the circulatory system	Venous thrombosis	I80-I82	F10
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases