CMAUP Plant Collective Molecular Activities

Plant Name: Gnetum cleistostachyum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	OPRD1;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	RECQL; PLA2G1B; TDP1; HSD11B1; AKR1B10; HSD17B10; POLB;
Protein Kinase	AURKB; AURKA; KDR;
Lyase	CA2; CA1; CA12; CA9; CA7; CA3; CA14; CA5B; CA5A; CA6;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Metallo protease	MMP1; MMP12; MMP2; MMP9;
Transcription Factor	NFKB1;
ATP-binding cassette	ABCG2;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.829E-13	2.131E-09	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NR1H4, PTPN1, RORC
BP	Unclassified;	GO:0044243; multicellular organismal catabolic process	3.055E-07	4.752E-04	MMP1, MMP12, MMP2, MMP9, PLA2G1B
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	1.402E-06	1.454E-03	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	1.967E-06	1.784E-03	MMP1, MMP12, MMP2, MMP9, PLA2G1B
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	3.788E-06	3.173E-03	AURKA, CA2, CA9, CYP1B1, LMNA, MMP9, NFKB1, OPRD1, POLB, PTPN1, PTPRF, RECQL, TDP1
BP	GO:0008152; metabolic process	GO:0030574; collagen catabolic process	7.909E-06	5.555E-03	MMP1, MMP12, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.129E-05	7.020E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.129E-05	7.020E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	1.129E-05	7.020E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:0022617; extracellular matrix disassembly	1.721E-05	9.608E-03	MMP1, MMP12, MMP2, MMP9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	7.094E-25	1.545E-20	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.642E-19	6.142E-15	CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.437E-17	6.258E-14	CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.236E-24	3.398E-22	CA12; CA1; CA3; CA5B; CA2; CA5A; CA7; CA6; CA9; CA14
hsa05219	Bladder cancer_Homo sapiens_hsa05219	6.417E-05	3.369E-03	MMP1; MMP2; MMP9
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.817E-04	6.358E-03	HSD11B1; CYP1A1; CYP1B1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.591E-04	6.540E-03	HSD11B1; CYP1A1; CYP1B1
hsa04520	Adherens junction_Homo sapiens_hsa04520	3.737E-04	6.540E-03	PTPN1; ACP1; PTPRF
hsa04976	Bile secretion_Homo sapiens_hsa04976	3.308E-04	6.540E-03	CA2; NR1H4; ABCG2
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	5.053E-04	7.579E-03	HSD11B1; CYP1A1; CYP1B1
hsa04931	Insulin resistance_Homo sapiens_hsa04931	1.156E-03	1.518E-02	PTPN1; NFKB1; PTPRF
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	2.364E-03	2.751E-02	CYP1B1; MMP9; NFKB1; CDC25B
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	2.620E-03	2.751E-02	CYP1A1; CYP1B1
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	4.066E-03	3.881E-02	CYP1A1; CYP1B1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Breast cancer	C50	CA9; KDR; KDR; KDR
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1; MMP12
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; KDR
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9; MMP9; MMP2; KDR; KDR; KDR; AURKB; AURKA
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	OPRD1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; AURKA
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1; MMP1; PLA2G1B
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Moderate-to-severe pain	R52, G89	OPRD1
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2
C00-D49: Neoplasms	Glioma	C71	KDR
C00-D49: Neoplasms	Thyroid cancer	C73	KDR
C00-D49: Neoplasms	Melanoma	C43	KDR; KDR
NA: NA	Colour dead tissues	NA	PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR
C00-D49: Neoplasms	Gastric cancer	C16	KDR; KDR
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2; KDR
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2; KDR
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12; PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1; NFKB1
C00-D49: Neoplasms	AML	NA	KDR
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA
C00-D49: Neoplasms	Liver cancer	C22	KDR
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12; MMP12
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2; KDR; KDR; KDR; KDR
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
NA: NA	Chronic diarrhea associated with inflammatory bowel disease	NA	OPRD1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1; PLA2G1B
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12; PLA2G1B
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	OPRD1
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
C00-D49: Neoplasms	Renal cancer	C64	CA9; KDR
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2; KDR; KDR
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B; CA1; CA9; MMP9; NFKB1; MMP2; KDR; AURKA
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR
N00-N99: Diseases of the genitourinary system	Bladder disease	N30-N32	OPRD1
NA: NA	Acute nonspecific diarrhea	NA	OPRD1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases