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Plant Name: Morinda morindoides




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
GPR35; ADRA2C; ADRA2A; DRD4;
Peptide receptor (family A GPCR)
NPSR1; CXCR1; NMUR2;
Enzyme_unclassified
RECQL; TDP1; PLA2G1B; BLM; APOBEC3G; CTDSP1; P4HB; PIK3CG; PIK3R1; GLO1; HPGD; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; NOX4; USP2; PYGL; APEX1; POLB;
Hydrolase
ACHE; GAA;
Protein Phosphatase
DUSP3;
Isomerase
TOP2A;
Protein Kinase
AKT1; MET; CAMK2B; GSK3B; CSNK2A1; DAPK1; SYK; NEK2; FLT3; NEK6; MYLK; SRC; IGF1R; PTK2; BRAF; AURKB; AURKA; FLT4; EPHB4; MAP3K8; TEK; PDGFRB; INSR; PLK4; CDK1; MAPK1; ERBB2; EGFR; PIM1; NUAK1; ALK; AXL; KDR; PLK1; PKN1;
Lyase
CA12; CA7; CA3; CA14; CA5B; CA5A; CA1; CA9; CA13; CA4; CA6; CA2;
Nuclear hormone receptor subfamily 3 group C
AR;
Nuclear hormone receptor subfamily 3 group B
ESRRA;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; TYR; XDH;
Metallo protease
MMP13; MMP3; MMP2; MMP9;
Aspartic protease
BACE1;
Transcription Factor
AHR; STAT6; HIF1A; NFKB1; TP53;
ATP-binding cassette
ABCC1; ABCG2;
SLC superfamily of solute carriers
SLC22A6;
Unclassified
SMAD3; LMNA; MAPT; HBB; THPO; APP; HSPA1A;
Methyl-lysine/arginine binding protein
L3MBTL1;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1A2; CYP19A1; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified PIK3R1 PI3-kinase p85-alpha subunit P27986 CHEMBL2506
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Enzyme_unclassified MPO Myeloperoxidase P05164 CHEMBL2439
Enzyme_unclassified HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified USP2 Ubiquitin carboxyl-terminal hydrolase 2 O75604 CHEMBL1293227
Enzyme_unclassified PYGL Liver glycogen phosphorylase P06737 CHEMBL2568
Enzyme_unclassified APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified PLA2G1B Phospholipase A2 group 1B P04054 CHEMBL4426
Enzyme_unclassified BLM Bloom syndrome protein P54132 CHEMBL1293237
Enzyme_unclassified APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Q9HC16 CHEMBL1741217
Enzyme_unclassified CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Q9GZU7 CHEMBL1795098
Enzyme_unclassified P4HB Protein disulfide-isomerase P07237 CHEMBL5422
Enzyme_unclassified PIK3CG PI3-kinase p110-gamma subunit P48736 CHEMBL3267
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Isomerase TOP2A DNA topoisomerase II alpha P11388 CHEMBL1806
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA13 Carbonic anhydrase XIII Q8N1Q1 CHEMBL3912
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP13 Matrix metalloproteinase 13 P45452 CHEMBL280
Metallo protease MMP3 Matrix metalloproteinase 3 P08254 CHEMBL283
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Nuclear hormone receptor subfamily 3 group B ESRRA Estrogen-related receptor alpha P11474 CHEMBL3429
Nuclear hormone receptor subfamily 3 group C AR Androgen Receptor P10275 CHEMBL1871
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase TYR Tyrosinase P14679 CHEMBL1973
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A P25024 CHEMBL4029
Peptide receptor (family A GPCR) NMUR2 Neuromedin-U receptor 2 Q9GZQ4 CHEMBL1075144
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 Q9HC98 CHEMBL4309
Protein Kinase MYLK Myosin light chain kinase, smooth muscle Q15746 CHEMBL2428
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase BRAF Serine/threonine-protein kinase B-raf P15056 CHEMBL5145
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase AURKA Serine/threonine-protein kinase Aurora-A O14965 CHEMBL4722
Protein Kinase FLT4 Vascular endothelial growth factor receptor 3 P35916 CHEMBL1955
Protein Kinase EPHB4 Ephrin type-B receptor 4 P54760 CHEMBL5147
Protein Kinase MAP3K8 Mitogen-activated protein kinase kinase kinase 8 P41279 CHEMBL4899
Protein Kinase TEK Tyrosine-protein kinase TIE-2 Q02763 CHEMBL4128
Protein Kinase PDGFRB Platelet-derived growth factor receptor beta P09619 CHEMBL1913
Protein Kinase INSR Insulin receptor P06213 CHEMBL1981
Protein Kinase PLK4 Serine/threonine-protein kinase PLK4 O00444 CHEMBL3788
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Kinase ERBB2 Receptor protein-tyrosine kinase erbB-2 P04626 CHEMBL1824
Protein Kinase EGFR Epidermal growth factor receptor erbB1 P00533 CHEMBL203
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase PLK1 Serine/threonine-protein kinase PLK1 P53350 CHEMBL3024
Protein Kinase PKN1 Protein kinase N1 Q16512 CHEMBL3384
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase CAMK2B CaM kinase II beta Q13554 CHEMBL4121
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase DAPK1 Death-associated protein kinase 1 P53355 CHEMBL2558
Protein Kinase SYK Tyrosine-protein kinase SYK P43405 CHEMBL2599
Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 P51955 CHEMBL3835
Protein Phosphatase DUSP3 Dual specificity protein phosphatase 3 P51452 CHEMBL2635
SLC superfamily of solute carriers SLC22A6 Solute carrier family 22 member 6 Q4U2R8 CHEMBL1641347
Small molecule receptor (family A GPCR) GPR35 G-protein coupled receptor 35 Q9HC97 CHEMBL1293267
Small molecule receptor (family A GPCR) ADRA2C Alpha-2c adrenergic receptor P18825 CHEMBL1916
Small molecule receptor (family A GPCR) ADRA2A Alpha-2a adrenergic receptor P08913 CHEMBL1867
Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor P21917 CHEMBL219
Transcription Factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Transcription Factor STAT6 Signal transducer and activator of transcription 6 P42226 CHEMBL5401
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Unclassified SMAD3 Mothers against decapentaplegic homolog 3 P84022 CHEMBL1293258
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified HBB Hemoglobin beta chain P68871 CHEMBL4331
Unclassified THPO Thrombopoietin P40225 CHEMBL1293256
Unclassified APP Beta amyloid A4 protein P05067 CHEMBL2487
Unclassified HSPA1A Heat shock 70 kDa protein 1 P0DMV8 CHEMBL5460
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 9.033E-12 1.329E-09 AXL, EGFR, ERBB2, INSR, MET, NOX4, PDGFRB, PIK3CG, PIK3R1, PTK2, SRC, TEK, THPO
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 9.410E-12 1.357E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
MF GO:0005488; binding GO:0005506; iron ion binding 1.736E-11 2.377E-09 ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, HBB, XDH
MF GO:0005488; binding GO:0020037; heme binding 1.999E-11 2.687E-09 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, HBB, MPO, NOX4, SRC
MF GO:0005488; binding GO:0008270; zinc ion binding 6.607E-10 7.493E-08 APOBEC3G, AR, BLM, CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESRRA, GLO1, L3MBTL1, MMP13, MMP2, MMP3, MMP9, SMAD3, TP53
MF Unclassified; GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity 9.653E-10 1.067E-07 EGFR, ERBB2, INSR, KDR, SYK
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 1.323E-09 1.441E-07 CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 2.302E-09 2.433E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 4.240E-09 4.255E-07 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 5.979E-09 5.865E-07 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 1.363E-08 1.285E-06 EGFR, IGF1R, INSR, KDR, PTK2, SRC, SYK
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 1.966E-08 1.814E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0009987; cellular process GO:0030168; platelet activation 2.411E-08 2.196E-06 ADRA2A, ADRA2C, AKT1, AXL, MAPK1, PIK3CG, PIK3R1, SRC, SYK
BP GO:0009987; cellular process GO:0070374; positive regulation of ERK1 and ERK2 cascade 3.474E-08 3.038E-06 ALOX15, APP, BRAF, EGFR, FLT4, KDR, NOX4, PDGFRB, SRC, TEK, THPO
CC GO:0044464; cell part GO:0005829; cytosol 4.737E-08 4.061E-06 AHR, AKR1B1, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APOBEC3G, APP, AR, AURKA, AURKB, BLM, BRAF, CA1, CA13, CA2, CA3, CA7, CAMK2B, CDK1, CSNK2A1, DUSP3, EPHB4, ERBB2, FLT3, GLO1, GSK3B, HBB, HIF1A, HPGD, HSD17B1, HSPA1A, LMNA, MAP3K8, MAPK1, MAPT, MYLK, NEK2, NEK6, NFKB1, PIK3CG, PIK3R1, PIM1, PKN1, PLA2G1B, PLK1, PLK4, PTK2, PYGL, SMAD3, SRC, STAT6, SYK, TP53, TYR, XDH
MF GO:0005488; binding GO:0046982; protein heterodimerization activity 6.049E-08 5.066E-06 ADRA2A, ADRA2C, AHR, AURKA, AXL, BRAF, EGFR, ERBB2, HIF1A, NFKB1, P4HB, PIK3R1, SMAD3, TOP2A, TP53, TYR
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 2.133E-07 1.683E-05 ABCC1, ADRA2A, CA2, CA4, CA9, EGFR, ERBB2, HPGD, SLC22A6, TEK
MF GO:0005488; binding GO:0042803; protein homodimerization activity 3.392E-07 2.600E-05 ABCG2, ACHE, ADRA2A, ADRA2C, AKT1, APOBEC3G, BLM, CAMK2B, FLT3, FLT4, HPGD, MAPT, NFKB1, PYGL, SLC22A6, SMAD3, TOP2A, TYR, XDH
BP GO:0032502; developmental process GO:0001525; angiogenesis 4.902E-07 3.668E-05 CYP1B1, EPHB4, FLT4, HIF1A, KDR, MMP2, PDGFRB, PIK3CG, PTK2, SYK, TEK
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 6.308E-07 4.594E-05 CYP1A2, CYP2C8, CYP2C9, CYP3A4
MF GO:0005488; binding GO:0043548; phosphatidylinositol 3-kinase binding 8.251E-07 5.815E-05 AXL, IGF1R, INSR, PDGFRB, PIK3R1
BP GO:0008152; metabolic process GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity 9.853E-07 6.698E-05 FLT3, PDGFRB, PTK2, SRC, TEK
BP GO:0009987; cellular process GO:0071276; cellular response to cadmium ion 1.169E-06 7.738E-05 AKT1, CYP1A2, EGFR, MAPK1, MMP9
BP Unclassified; GO:0032846; positive regulation of homeostatic process 1.275E-06 8.390E-05 AURKB, CA2, CA7, EGFR, HIF1A, MAPK1, NEK2, NPSR1, PLA2G1B, SYK
MF GO:0005488; binding GO:0019838; growth factor binding 1.334E-06 8.720E-05 EGFR, ERBB2, FLT4, IGF1R, INSR, KDR, PDGFRB, TEK
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 1.379E-06 8.990E-05 AHR, CSNK2A1, HIF1A, KDR, MAPT
BP GO:0032502; developmental process GO:0007568; aging 1.554E-06 9.954E-05 AKT1, APEX1, AURKB, CDK1, CYP1A1, MPO, NOX4, PDGFRB, POLB, TP53
BP GO:0009987; cellular process GO:0038084; vascular endothelial growth factor signaling pathway 1.715E-06 1.085E-04 FLT3, FLT4, KDR, PDGFRB
BP GO:0065007; biological regulation GO:0032148; activation of protein kinase B activity 1.887E-06 1.184E-04 ADRA2A, ADRA2C, AKT1, INSR, SRC
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 1.931E-06 1.205E-04 AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 2.203E-06 1.340E-04 CYP1A1, CYP2C8, CYP3A4
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 2.276E-06 1.373E-04 ALOX12, ALOX15, ALOX5, HPGD
BP GO:0065007; biological regulation GO:0000187; activation of MAPK activity 2.731E-06 1.589E-04 ALK, CDK1, DRD4, INSR, MAPK1, PKN1, PLA2G1B, SYK
MF GO:0003824; catalytic activity GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity 3.082E-06 1.757E-04 EGFR, ERBB2, MET, PDGFRB, PIK3CG, PIK3R1
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 4.386E-06 2.387E-04 CYP1A1, CYP2C8, CYP3A4
CC GO:0032991; macromolecular complex GO:0043235; receptor complex 4.565E-06 2.479E-04 ABCG2, ADRA2A, AHR, APP, EGFR, ERBB2, FLT4, IGF1R, INSR, SMAD3, SYK
BP GO:0008152; metabolic process GO:0045429; positive regulation of nitric oxide biosynthetic process 4.911E-06 2.654E-04 AKT1, EGFR, HBB, INSR, SMAD3
BP GO:0009987; cellular process GO:0048010; vascular endothelial growth factor receptor signaling pathway 5.144E-06 2.765E-04 AXL, FLT4, KDR, PIK3R1, PTK2, SRC
BP GO:0009987; cellular process GO:0070507; regulation of microtubule cytoskeleton organization 6.006E-06 3.174E-04 AURKA, GSK3B, HSPA1A, MAPT, MET, NEK2, PLK1, PLK4
BP Unclassified; GO:0032844; regulation of homeostatic process 6.788E-06 3.536E-04 ADRA2A, AURKB, CA2, CA7, EGFR, HIF1A, KDR, MAPK1, NEK2, NPSR1, PLA2G1B, SRC, SYK
BP GO:0050896; response to stimulus GO:0055093; response to hyperoxia 7.309E-06 3.754E-04 CYP1A1, PDGFRB, POLB, TP53
MF GO:0060089; molecular transducer activity GO:0005021; vascular endothelial growth factor-activated receptor activity 7.641E-06 3.869E-04 FLT3, FLT4, KDR
BP GO:0023052; signaling GO:0050806; positive regulation of synaptic transmission 9.433E-06 4.733E-04 APP, BRAF, CA2, CA7, DRD4, EGFR, MAPK1
MF GO:0005488; binding GO:0051379; epinephrine binding 1.217E-05 5.929E-04 ADRA2A, ADRA2C, DRD4
BP GO:0009987; cellular process GO:1901796; regulation of signal transduction by p53 class mediator 1.264E-05 6.076E-04 AKT1, AURKA, AURKB, BLM, CSNK2A1, L3MBTL1, NUAK1, TP53
CC GO:0043226; organelle GO:0005654; nucleoplasm 1.773E-05 8.201E-04 AHR, AKR1B1, AKT1, ALOX5, APEX1, AR, AURKA, AURKB, BLM, CAMK2B, CDK1, CSNK2A1, CTDSP1, DUSP3, ESRRA, GSK3B, HIF1A, HPGD, HSPA1A, L3MBTL1, LMNA, MAPK1, NEK2, NEK6, NFKB1, NUAK1, PIM1, PKN1, PLK1, POLB, RECQL, SMAD3, SRC, STAT6, TOP2A, TP53, USP2
CC GO:0043226; organelle GO:0005876; spindle microtubule 1.774E-05 8.201E-04 AURKA, AURKB, CDK1, PLK1, POLB
BP GO:0032501; multicellular organismal process GO:0048143; astrocyte activation 1.817E-05 8.355E-04 APP, EGFR, MAPT
BP GO:0009987; cellular process GO:0000733; DNA strand renaturation 1.817E-05 8.355E-04 BLM, RECQL, TP53
BP GO:0008152; metabolic process GO:0031324; negative regulation of cellular metabolic process 1.954E-05 8.903E-04 ADRA2A, AHR, AKT1, APEX1, APP, AR, AURKB, BLM, CDK1, CSNK2A1, CTDSP1, DAPK1, DRD4, DUSP3, ESRRA, GSK3B, HIF1A, HSPA1A, IGF1R, L3MBTL1, MAPT, MET, MMP3, MMP9, NFKB1, PIK3CG, PKN1, PLK1, SMAD3, SRC, STAT6, TP53, USP2, XDH
MF Unclassified; GO:0004872; receptor activity 1.961E-05 8.915E-04 ADRA2A, ADRA2C, AHR, ALK, AR, AXL, CXCR1, DRD4, EGFR, EPHB4, ERBB2, ESRRA, FLT3, FLT4, GPR35, HPGD, IGF1R, INSR, KDR, MET, NMUR2, NPSR1, PDGFRB, TEK
BP GO:0009987; cellular process GO:0043065; positive regulation of apoptotic process 2.072E-05 9.363E-04 AKT1, CYP1B1, DAPK1, GSK3B, HPGD, MAPT, MMP9, NOX4, PDGFRB, SMAD3, SRC, TOP2A, TP53, XDH
BP GO:0008152; metabolic process GO:0045740; positive regulation of DNA replication 2.130E-05 9.601E-04 CDK1, EGFR, IGF1R, INSR, PLA2G1B
MF Unclassified; GO:0099600; transmembrane receptor activity 2.185E-05 9.788E-04 ADRA2A, ADRA2C, ALK, AXL, CXCR1, DRD4, EGFR, EPHB4, ERBB2, FLT3, FLT4, GPR35, HPGD, IGF1R, INSR, KDR, MET, NMUR2, NPSR1, PDGFRB, TEK
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 6.812E-25 3.708E-21 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF Unclassified; GO:0032403; protein complex binding 2.686E-05 1.165E-03 ACHE, ADRA2A, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP13, MMP9, P4HB, PIK3R1, PLK1, SMAD3, SRC, SYK
BP GO:0050896; response to stimulus GO:0001101; response to acid chemical 2.864E-05 1.235E-03 AKR1B1, AKT1, EGFR, HSD17B2, KDR, MMP2, PDGFRB, SLC22A6, SRC, TP53
BP GO:0009987; cellular process GO:0010389; regulation of G2/M transition of mitotic cell cycle 2.955E-05 1.272E-03 APP, AURKA, AURKB, BLM, CDK1, NEK2, PLK1, PLK4
BP GO:0008152; metabolic process GO:0046854; phosphatidylinositol phosphorylation 3.227E-05 1.372E-03 EGFR, ERBB2, MET, PDGFRB, PIK3CG, PIK3R1
MF GO:0005488; binding GO:0043560; insulin receptor substrate binding 3.538E-05 1.482E-03 IGF1R, INSR, PIK3R1
BP GO:0065007; biological regulation GO:0043006; activation of phospholipase A2 activity by calcium-mediated signaling 3.700E-05 1.517E-03 EGFR, NMUR2
BP GO:0009987; cellular process GO:0006286; base-excision repair, base-free sugar-phosphate removal 3.700E-05 1.517E-03 APEX1, POLB
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 3.700E-05 1.517E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 3.700E-05 1.517E-03 ALOX12, ALOX15
CC GO:0043226; organelle GO:0051233; spindle midzone 3.665E-05 1.517E-03 APP, AURKA, AURKB, PLK1
BP GO:0065007; biological regulation GO:0043393; regulation of protein binding 3.785E-05 1.549E-03 APP, AURKA, AURKB, GSK3B, MET, MMP9, PLK1, SRC
BP GO:0009987; cellular process GO:2001237; negative regulation of extrinsic apoptotic signaling pathway 4.037E-05 1.637E-03 AKT1, AR, DAPK1, HSPA1A, LMNA, SRC
BP GO:0032501; multicellular organismal process GO:0003007; heart morphogenesis 4.169E-05 1.684E-03 EPHB4, GAA, INSR, PTK2
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 4.262E-05 1.719E-03 AKT1, HIF1A, LMNA, P4HB, SRC, TP53
BP Unclassified; GO:0044236; multicellular organism metabolic process 4.745E-05 1.892E-03 HIF1A, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0009987; cellular process GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling 5.186E-05 2.046E-03 FLT3, KDR, PDGFRB, PTK2, TEK
BP GO:0065007; biological regulation GO:0042593; glucose homeostasis 5.505E-05 2.148E-03 ADRA2A, AKT1, HIF1A, INSR, NOX4, PIK3R1, PYGL
BP GO:0008152; metabolic process GO:0045913; positive regulation of carbohydrate metabolic process 5.991E-05 2.325E-03 AKT1, HIF1A, INSR, NFKB1, SRC
BP GO:0008152; metabolic process GO:0006703; estrogen biosynthetic process 6.078E-05 2.355E-03 CYP19A1, HSD17B1, HSD17B2
MF GO:0005488; binding GO:0002039; p53 binding 6.888E-05 2.622E-03 BLM, GSK3B, HIF1A, NUAK1, TP53
BP GO:0032501; multicellular organismal process GO:0001503; ossification 7.130E-05 2.709E-03 ALOX15, EGFR, MMP13, MMP2, MMP9, TEK
BP GO:0009987; cellular process GO:0031334; positive regulation of protein complex assembly 7.294E-05 2.767E-03 ALOX15, GSK3B, HSPA1A, MAPT, MET, MMP3, SRC, TP53
BP GO:0050896; response to stimulus GO:0034405; response to fluid shear stress 7.479E-05 2.818E-03 AKT1, CA2, PDGFRB, SRC
BP Unclassified; GO:0044243; multicellular organismal catabolic process 8.425E-05 3.152E-03 MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0009987; cellular process GO:0038128; ERBB2 signaling pathway 9.227E-05 3.411E-03 EGFR, ERBB2, PIK3R1, SRC
BP GO:0032501; multicellular organismal process GO:0045780; positive regulation of bone resorption 9.584E-05 3.519E-03 CA2, EGFR, SYK
BP GO:0022610; biological adhesion GO:0033628; regulation of cell adhesion mediated by integrin 1.020E-04 3.694E-03 CYP1B1, PIK3CG, PTK2, SYK
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.106E-04 3.941E-03 CA2, CA7
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.106E-04 3.941E-03 CYP1A1, CYP3A4
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.106E-04 3.941E-03 ALOX12, ALOX15
MF GO:0060089; molecular transducer activity GO:0004938; alpha2-adrenergic receptor activity 1.106E-04 3.941E-03 ADRA2A, ADRA2C
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.106E-04 3.941E-03 ALOX12, ALOX15
BP Unclassified; GO:0006461; protein complex assembly 1.115E-04 3.959E-03 ACHE, AR, BLM, BRAF, CDK1, GSK3B, HBB, HSD17B10, HSPA1A, IGF1R, INSR, MAPT, PTK2, SLC22A6, SMAD3, SRC, TEK, TP53
BP GO:0032502; developmental process GO:0045597; positive regulation of cell differentiation 1.136E-04 4.016E-03 ADRA2C, AKT1, APP, AR, AURKA, AXL, BRAF, CA2, CAMK2B, HIF1A, KDR, MAPT, NFKB1, SMAD3, SYK, THPO
BP GO:0009987; cellular process GO:1900034; regulation of cellular response to heat 1.156E-04 4.079E-03 CAMK2B, GSK3B, HSPA1A, MAPK1, MAPT
MF GO:0003824; catalytic activity GO:0004712; protein serine/threonine/tyrosine kinase activity 1.238E-04 4.341E-03 AKT1, AURKA, AURKB, MAPK1
BP GO:0009987; cellular process GO:0006974; cellular response to DNA damage stimulus 1.296E-04 4.515E-03 AKT1, APEX1, AURKA, BLM, CDK1, MAPK1, NUAK1, PIK3R1, PLK1, POLB, RECQL, TDP1, TOP2A, TP53
BP GO:0008152; metabolic process GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process 1.382E-04 4.755E-03 AKT1, AURKA, GSK3B, HSPA1A, PLK1
BP GO:0050896; response to stimulus GO:1901655; cellular response to ketone 1.382E-04 4.755E-03 AKR1B1, AKT1, AR, EGFR, SRC
BP GO:0065007; biological regulation GO:1904355; positive regulation of telomere capping 1.420E-04 4.861E-03 AURKB, MAPK1, NEK2
MF GO:0003824; catalytic activity GO:0008392; arachidonic acid epoxygenase activity 1.420E-04 4.861E-03 CYP2C19, CYP2C8, CYP2C9
BP GO:0065007; biological regulation GO:0031647; regulation of protein stability 1.472E-04 5.007E-03 AURKA, HSPA1A, MAPK1, PIK3R1, PLK1, SMAD3, SRC, USP2
BP GO:0009987; cellular process GO:0007077; mitotic nuclear envelope disassembly 1.487E-04 5.045E-03 CDK1, LMNA, NEK6, PLK1
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 1.625E-04 5.486E-03 AKT1, LMNA, MMP9, TP53
CC GO:0044464; cell part GO:0048471; perinuclear region of cytoplasm 1.637E-04 5.519E-03 ACHE, AKR1B1, APEX1, APP, AURKA, CA4, EGFR, ERBB2, HSPA1A, NOX4, SRC, TYR, USP2
BP GO:0008152; metabolic process GO:0032928; regulation of superoxide anion generation 1.696E-04 5.664E-03 EGFR, MAPT, SYK
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 1.834E-04 6.051E-03 HIF1A, MMP13, MMP2, MMP3, MMP9
BP GO:0008283; cell proliferation GO:0001938; positive regulation of endothelial cell proliferation 1.834E-04 6.051E-03 AKT1, FLT4, HIF1A, KDR, TEK
BP GO:0065007; biological regulation GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway 2.203E-04 7.021E-03 ADRA2A, ADRA2C
BP GO:0009987; cellular process GO:0032811; negative regulation of epinephrine secretion 2.203E-04 7.021E-03 ADRA2A, ADRA2C
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 2.203E-04 7.021E-03 CYP1A1, CYP1A2
BP GO:0065007; biological regulation GO:0051092; positive regulation of NF-kappaB transcription factor activity 2.206E-04 7.021E-03 ALK, APP, AR, HSPA1A, NFKB1, PLA2G1B
MF GO:0005488; binding GO:0051425; PTB domain binding 2.203E-04 7.021E-03 APP, INSR
MF GO:0005488; binding GO:0005497; androgen binding 2.203E-04 7.021E-03 ALDH1A1, AR
BP GO:0050896; response to stimulus GO:0071320; cellular response to cAMP 2.453E-04 7.664E-03 APEX1, APP, NOX4, PIK3CG
MF GO:0005488; binding GO:0003682; chromatin binding 2.520E-04 7.829E-03 APEX1, AR, CDK1, EGFR, L3MBTL1, MPO, NFKB1, PKN1, SMAD3, TOP2A, TP53
BP GO:0009987; cellular process GO:0051983; regulation of chromosome segregation 2.921E-04 8.959E-03 AURKB, CSNK2A1, NEK2, NEK6, PLK1
BP GO:0009987; cellular process GO:2001243; negative regulation of intrinsic apoptotic signaling pathway 2.921E-04 8.959E-03 AKT1, HIF1A, HSPA1A, MMP9, SRC
CC GO:0044464; cell part GO:0005739; mitochondrion 3.040E-04 9.297E-03 AKT1, APEX1, BRAF, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, GSK3B, HSD17B10, HSPA1A, MAOA, MAPK1, MMP2, MPO, NFKB1, NOX4, SRC, TP53
BP GO:0008152; metabolic process GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter 3.144E-04 9.537E-03 HIF1A, SMAD3, TP53
BP GO:0008283; cell proliferation GO:1904707; positive regulation of vascular smooth muscle cell proliferation 3.144E-04 9.537E-03 HPGD, MMP2, MMP9
BP GO:0008152; metabolic process GO:0050995; negative regulation of lipid catabolic process 3.144E-04 9.537E-03 ADRA2A, AKT1, PIK3CG
MF GO:0005488; binding GO:0005524; ATP binding 8.178E-20 7.621E-17 ABCC1, ABCG2, AKT1, ALK, AURKA, AURKB, AXL, BLM, BRAF, CAMK2B, CDK1, CSNK2A1, DAPK1, EGFR, EPHB4, ERBB2, FLT3, FLT4, GSK3B, HSPA1A, IGF1R, INSR, KDR, MAP3K8, MAPK1, MET, MYLK, NEK2, NEK6, NUAK1, PDGFRB, PIK3CG, PIM1, PKN1, PLK1, PLK4, PTK2, PYGL, RECQL, SRC, SYK, TEK, TOP2A, TP53
BP GO:0051179; localization GO:0015701; bicarbonate transport 3.703E-19 2.520E-16 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, HBB
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.451E-16 5.354E-14 CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF GO:0005488; binding GO:0019825; oxygen binding 1.308E-13 2.590E-11 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, HBB, NOX4
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 6.044E-24 1.136E-21 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 3.726E-15 3.225E-13 CAMK2B; SRC; MMP2; BRAF; PIK3R1; HIF1A; MMP9; PTK2; EGFR; PIK3CG; IGF1R; ERBB2; KDR; AKT1; MAPK1; TP53; MET
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 1.734E-14 8.148E-13 PDGFRB; GSK3B; SMAD3; FLT3; DAPK1; MMP2; BRAF; PIK3R1; HIF1A; MMP9; EGFR; NFKB1; PIK3CG; PTK2; IGF1R; AR; ERBB2; AKT1; MAPK1; MET; TP53
hsa05215 Prostate cancer_Homo sapiens_hsa05215 5.146E-15 3.225E-13 PDGFRB; GSK3B; BRAF; PIK3R1; EGFR; NFKB1; PIK3CG; IGF1R; AR; ERBB2; AKT1; MAPK1; TP53
hsa04510 Focal adhesion_Homo sapiens_hsa04510 6.081E-14 2.286E-12 PDGFRB; GSK3B; SRC; FLT4; BRAF; PIK3R1; PTK2; EGFR; PIK3CG; MYLK; IGF1R; ERBB2; KDR; AKT1; MAPK1; MET
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 1.585E-12 3.726E-11 PDGFRB; GSK3B; SYK; INSR; FLT4; PIK3R1; PTK2; EGFR; NFKB1; PIK3CG; IGF1R; KDR; AKT1; MAPK1; TEK; PKN1; TP53; MET
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 1.824E-13 5.716E-12 PDGFRB; FLT3; ERBB2; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A; EGFR; PIK3CG
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 9.791E-13 2.629E-11 CAMK2B; INSR; ERBB2; AKT1; MAPK1; TEK; PIK3R1; HIF1A; EGFR; NFKB1; PIK3CG; IGF1R
hsa05214 Glioma_Homo sapiens_hsa05214 4.726E-12 8.077E-11 PDGFRB; CAMK2B; AKT1; MAPK1; BRAF; PIK3R1; TP53; EGFR; PIK3CG; IGF1R
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 3.603E-12 6.774E-11 CAMK2B; GSK3B; SRC; ERBB2; AKT1; MAPK1; BRAF; PIK3R1; EGFR; PTK2; PIK3CG
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 5.543E-12 8.684E-11 SMAD3; ERBB2; AKT1; MAPK1; BRAF; PIK3R1; TP53; EGFR; NFKB1; PIK3CG
hsa05219 Bladder cancer_Homo sapiens_hsa05219 1.900E-12 3.969E-11 DAPK1; SRC; MMP2; ERBB2; MAPK1; BRAF; MMP9; TP53; EGFR
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 2.729E-11 3.420E-10 PDGFRB; SRC; INSR; FLT4; BRAF; PIK3R1; EGFR; PIK3CG; IGF1R; KDR; AKT1; MAPK1; TEK; MET
hsa05218 Melanoma_Homo sapiens_hsa05218 1.184E-11 1.712E-10 PDGFRB; AKT1; MAPK1; BRAF; PIK3R1; TP53; MET; EGFR; PIK3CG; IGF1R
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 7.248E-11 8.015E-10 PDGFRB; PLA2G1B; INSR; FLT4; PIK3R1; EGFR; NFKB1; PIK3CG; IGF1R; KDR; AKT1; MAPK1; TEK; MET
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 1.890E-11 2.538E-10 GSK3B; ERBB2; AKT1; MAPK1; BRAF; PIK3R1; TP53; EGFR; PIK3CG
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 3.817E-11 4.485E-10 ALK; ERBB2; AKT1; MAPK1; BRAF; PIK3R1; TP53; EGFR; PIK3CG
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 3.870E-10 3.830E-09 PLK4; SMAD3; INSR; PLK1; AKT1; MAPK1; BRAF; PIK3R1; EGFR; PIK3CG; IGF1R
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 1.185E-09 1.013E-08 CYP2C9; APP; CYP2C8; MAOA; ALOX5; ALOX15; MAPK1; BRAF; ALOX12; CYP2C19
hsa04520 Adherens junction_Homo sapiens_hsa04520 5.096E-10 4.563E-09 SMAD3; CSNK2A1; SRC; INSR; ERBB2; MAPK1; MET; EGFR; IGF1R
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 5.042E-10 4.563E-09 HSD17B1; ALOX5; INSR; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 7.059E-09 5.308E-08 SRC; MMP2; AKT1; MAPK1; PIK3R1; MMP9; EGFR; PIK3CG; HSPA1A
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 1.499E-09 1.226E-08 FLT3; PIM1; AKT1; MAPK1; BRAF; PIK3R1; NFKB1; PIK3CG
hsa05161 Hepatitis B_Homo sapiens_hsa05161 1.568E-08 1.092E-07 SMAD3; SRC; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1; PIK3CG
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 2.994E-09 2.345E-08 GSK3B; SMAD3; AKT1; MAPK1; BRAF; PIK3R1; TP53; PIK3CG
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 1.128E-08 8.155E-08 SMAD3; AKT1; MAPK1; BRAF; PIK3R1; TP53; NFKB1; PIK3CG
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 3.846E-08 2.582E-07 CAMK2B; GSK3B; AKT1; MAPK1; BRAF; PIK3R1; TP53; NFKB1; PIK3CG
hsa05160 Hepatitis C_Homo sapiens_hsa05160 9.389E-08 5.516E-07 GSK3B; AKT1; MAPK1; BRAF; PIK3R1; TP53; EGFR; NFKB1; PIK3CG
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 1.478E-07 7.721E-07 SMAD3; MMP2; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PIK3CG
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 1.168E-07 6.460E-07 PLK1; CDK1; AKT1; MAPK1; BRAF; PIK3R1; PIK3CG; IGF1R
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 1.143E-07 6.460E-07 HPGD; FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 1.633E-07 8.298E-07 GSK3B; CXCR1; SRC; AKT1; MAPK1; BRAF; PIK3R1; NFKB1; PTK2; PIK3CG
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 6.971E-08 4.369E-07 SRC; KDR; AKT1; MAPK1; PIK3R1; PTK2; PIK3CG
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 1.858E-07 9.193E-07 PDGFRB; SYK; CXCR1; INSR; AKT1; MAPK1; PIK3R1; EGFR; PIK3CG
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 3.342E-07 1.467E-06 GSK3B; SYK; CSNK2A1; CDK1; AKT1; PIK3R1; TP53; NFKB1; PIK3CG; HSPA1A
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 3.356E-07 1.467E-06 PDGFRB; DUSP3; AKT1; MAPK1; BRAF; MAP3K8; MAPT; TP53; EGFR; NFKB1; HSPA1A
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 2.914E-10 3.044E-09 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 2.868E-07 1.315E-06 MMP3; AKT1; MAPK1; MAP3K8; PIK3R1; MMP9; NFKB1; PIK3CG
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 7.821E-08 4.743E-07 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 1.215E-07 6.524E-07 AKT1; MAPK1; BRAF; PIK3R1; MET; HIF1A; PIK3CG
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 4.875E-08 3.161E-07 HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 2.231E-07 1.076E-06 GSK3B; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PIK3CG
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 2.456E-07 1.154E-06 GSK3B; SYK; AKT1; MAPK1; PIK3R1; NFKB1; PIK3CG
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 4.924E-07 2.104E-06 GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; HIF1A; PIK3CG
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 1.506E-06 5.779E-06 PDGFRB; ABCC1; ERBB2; PIM1; CYP1B1; MAPK1; TP53; MMP9; MET; EGFR; NFKB1
hsa05162 Measles_Homo sapiens_hsa05162 1.451E-06 5.682E-06 GSK3B; CSNK2A1; AKT1; PIK3R1; TP53; NFKB1; PIK3CG; HSPA1A
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 1.393E-06 5.682E-06 INSR; AKT1; PIK3R1; TP53; NFKB1; PIK3CG; IGF1R
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 1.710E-06 6.430E-06 GSK3B; INSR; AKT1; MAPK1; BRAF; PIK3R1; PYGL; PIK3CG
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 3.572E-06 1.199E-05 POLB; SYK; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1; PIK3CG
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 2.263E-06 8.182E-06 PDGFRB; AKT1; MAPK1; PIK3R1; HIF1A; EGFR; PIK3CG
hsa04810 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 5.069E-06 1.643E-05 PDGFRB; SRC; MAPK1; BRAF; PIK3R1; PTK2; EGFR; PIK3CG; MYLK
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 5.486E-07 2.292E-06 CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 2.755E-06 9.591E-06 GSK3B; AKT1; MAPK1; MAP3K8; PIK3R1; NFKB1; PIK3CG
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 1.072E-05 3.148E-05 PLA2G1B; MAOA; GAA; ALOX15; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; TYR; CYP19A1; HSD17B10; CYP2C9; CYP2C8; HSD17B1; ALOX5; HSD17B2; CYP1A2; ALDH1A1; CYP1A1; XDH
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 6.705E-06 2.101E-05 INSR; AKT1; MAPK1; PIK3R1; ADRA2C; ADRA2A; PIK3CG; MYLK
hsa04931 Insulin resistance_Homo sapiens_hsa04931 3.771E-06 1.244E-05 GSK3B; INSR; AKT1; PIK3R1; PYGL; NFKB1; PIK3CG
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 6.388E-06 2.036E-05 ALOX5; AKT1; MAPK1; PIK3R1; NFKB1; PIK3CG; HSPA1A
hsa04611 Platelet activation_Homo sapiens_hsa04611 7.960E-06 2.414E-05 SYK; SRC; AKT1; MAPK1; PIK3R1; PIK3CG; MYLK
hsa04210 Apoptosis_Homo sapiens_hsa04210 1.956E-05 5.571E-05 LMNA; AKT1; MAPK1; PIK3R1; TP53; NFKB1; PIK3CG
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 1.433E-06 5.682E-06 AKT1; MAPK1; BRAF; PIK3R1; HIF1A; PIK3CG
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 2.263E-05 6.258E-05 PDGFRB; POLB; GSK3B; SMAD3; AKT1; PIK3R1; TP53; NFKB1; PIK3CG
hsa04114 Oocyte meiosis_Homo sapiens_hsa04114 8.400E-06 2.507E-05 CAMK2B; AR; PLK1; CDK1; MAPK1; AURKA; IGF1R
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 7.138E-06 2.200E-05 ABCC1; AKT1; MAPK1; PIK3R1; TP53; NFKB1; PIK3CG
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 2.144E-05 6.016E-05 GSK3B; SMAD3; AKT1; MAPK1; PIK3R1; PIK3CG; IGF1R
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 2.105E-06 7.759E-06 INSR; AKT1; PIK3R1; PIK3CG; HSPA1A; IGF1R
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 4.255E-05 1.127E-04 CAMK2B; SRC; MAPK1; PIK3R1; EGFR; PIK3CG; MYLK
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 5.076E-05 1.292E-04 CAMK2B; ACHE; AKT1; MAPK1; PIK3R1; PIK3CG
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 3.917E-05 1.052E-04 AKT1; MAPK1; MAP3K8; PIK3R1; NFKB1; PIK3CG
hsa05164 Influenza A_Homo sapiens_hsa05164 8.120E-05 1.983E-04 GSK3B; AKT1; MAPK1; PIK3R1; NFKB1; PIK3CG; HSPA1A
hsa04144 Endocytosis_Homo sapiens_hsa04144 1.523E-04 3.534E-04 SMAD3; CXCR1; SRC; KDR; MET; EGFR; HSPA1A; IGF1R
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 3.517E-05 9.583E-05 SMAD3; AKT1; MAPK1; PIK3R1; NFKB1; PIK3CG
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 3.286E-06 1.123E-05 CYP2C9; CYP2C8; MAOA; CYP1A2; CYP3A4; CYP2C19
hsa04060 Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 1.781E-04 4.033E-04 PDGFRB; CXCR1; THPO; FLT3; FLT4; KDR; MET; EGFR
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 2.308E-06 8.186E-06 CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 1.188E-05 3.436E-05 AKT1; PIK3R1; TP53; NFKB1; PTK2; PIK3CG
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 1.328E-04 3.120E-04 SYK; AKT1; MAPK1; PIK3R1; NFKB1; PIK3CG
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 1.804E-04 4.038E-04 CAMK2B; AKT1; MAPK1; BRAF; PIK3R1; NFKB1; PIK3CG
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 2.757E-04 5.891E-04 GSK3B; INSR; AKT1; PIK3R1; NFKB1; PIK3CG
hsa04630 Jak-STAT signaling pathway_Homo sapiens_hsa04630 3.516E-04 7.185E-04 THPO; PIM1; AKT1; STAT6; PIK3R1; PIK3CG
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 4.873E-04 9.850E-04 BACE1; APP; GSK3B; MAPK1; MAPT; HSD17B10
hsa05152 Tuberculosis_Homo sapiens_hsa05152 6.607E-04 1.307E-03 CAMK2B; SYK; SRC; AKT1; MAPK1; NFKB1
hsa04020 Calcium signaling pathway_Homo sapiens_hsa04020 4.310E-03 7.572E-03 PDGFRB; CAMK2B; ERBB2; EGFR; MYLK
hsa04080 Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 2.427E-02 3.651E-02 GPR35; NMUR2; ADRA2C; ADRA2A; DRD4
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 2.407E-02 3.649E-02 CSNK2A1; CDK1; TP53; NFKB1
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 1.856E-03 3.388E-03 CAMK2B; AKT1; MAPK1; PIK3R1; PIK3CG
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 1.547E-03 2.852E-03 CAMK2B; GSK3B; SMAD3; CSNK2A1; TP53
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 2.880E-04 6.083E-04 CAMK2B; SRC; ALOX12; PIK3R1; PIK3CG
hsa04650 Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 1.237E-03 2.302E-03 SYK; MAPK1; BRAF; PIK3R1; PIK3CG
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 2.038E-04 4.454E-04 CAMK2B; SRC; MMP2; MAPK1; EGFR
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 2.256E-04 4.875E-04 SYK; AKT1; MAPK1; PIK3R1; PIK3CG
hsa04152 AMPK signaling pathway_Homo sapiens_hsa04152 8.455E-04 1.622E-03 INSR; AKT1; PIK3R1; PIK3CG; IGF1R
hsa04110 Cell cycle_Homo sapiens_hsa04110 8.455E-04 1.622E-03 GSK3B; SMAD3; PLK1; CDK1; TP53
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 5.087E-05 1.292E-04 SYK; AKT1; MAPK1; PIK3R1; PIK3CG
hsa04360 Axon guidance_Homo sapiens_hsa04360 9.415E-04 1.788E-03 GSK3B; MAPK1; MET; PTK2; EPHB4
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 1.010E-03 1.898E-03 CAMK2B; GSK3B; MAOA; AKT1; DRD4
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 6.757E-04 1.323E-03 MMP2; PIK3R1; MMP9; PTK2; PIK3CG
hsa04540 Gap junction_Homo sapiens_hsa04540 1.741E-04 3.991E-04 PDGFRB; SRC; CDK1; MAPK1; EGFR
hsa04270 Vascular smooth muscle contraction_Homo sapiens_hsa04270 5.593E-03 9.646E-03 PLA2G1B; MAPK1; BRAF; MYLK
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 2.196E-02 3.357E-02 CAMK2B; AKT1; PYGL
hsa04916 Melanogenesis_Homo sapiens_hsa04916 2.921E-03 5.180E-03 CAMK2B; GSK3B; MAPK1; TYR
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 9.830E-05 2.339E-04 SRC; PIK3R1; MET; PTK2; PIK3CG
hsa05146 Amoebiasis_Homo sapiens_hsa05146 2.921E-03 5.180E-03 PIK3R1; NFKB1; PTK2; PIK3CG
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 7.160E-05 1.795E-04 CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 1.769E-02 2.771E-02 SYK; CSNK2A1; NFKB1
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 5.087E-05 1.292E-04 CXCR1; SRC; MET; EGFR; NFKB1
hsa05132 Salmonella infection_Homo sapiens_hsa05132 1.437E-02 2.289E-02 MAPK1; PKN1; NFKB1
hsa04971 Gastric acid secretion_Homo sapiens_hsa04971 9.575E-03 1.565E-02 CAMK2B; CA2; MYLK
hsa04976 Bile secretion_Homo sapiens_hsa04976 8.551E-03 1.410E-02 CA2; CYP3A4; ABCG2
hsa04720 Long-term potentiation_Homo sapiens_hsa04720 6.993E-03 1.174E-02 CAMK2B; MAPK1; BRAF
hsa05131 Shigellosis_Homo sapiens_hsa05131 6.704E-03 1.135E-02 SRC; MAPK1; NFKB1
hsa04730 Long-term depression_Homo sapiens_hsa04730 5.365E-03 9.339E-03 MAPK1; BRAF; IGF1R
hsa05321 Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 6.704E-03 1.135E-02 SMAD3; STAT6; NFKB1
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 3.337E-04 6.971E-04 INSR; AKT1; PIK3R1; PIK3CG
hsa05144 Malaria_Homo sapiens_hsa05144 3.390E-02 4.940E-02 HBB; MET
hsa05030 Cocaine addiction_Homo sapiens_hsa05030 3.390E-02 4.940E-02 MAOA; NFKB1
hsa00983 Drug metabolism - other enzymes_Homo sapiens_hsa00983 3.018E-02 4.467E-02 CYP3A4; XDH
hsa02010 ABC transporters_Homo sapiens_hsa02010 2.779E-02 4.147E-02 ABCC1; ABCG2
hsa04930 Type II diabetes mellitus_Homo sapiens_hsa04930 1.833E-04 4.055E-04 INSR; MAPK1; PIK3R1; PIK3CG
hsa04973 Carbohydrate digestion and absorption_Homo sapiens_hsa04973 2.372E-03 4.287E-03 AKT1; PIK3R1; PIK3CG
hsa04960 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 8.074E-05 1.983E-04 INSR; MAPK1; PIK3R1; PIK3CG
hsa05020 Prion diseases_Homo sapiens_hsa05020 1.809E-02 2.788E-02 MAPK1; HSPA1A
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.348E-02 2.166E-02 GAA; AKR1B1
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 8.930E-05 2.152E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa00350 Tyrosine metabolism_Homo sapiens_hsa00350 1.809E-02 2.788E-02 MAOA; TYR
hsa03410 Base excision repair_Homo sapiens_hsa03410 1.618E-02 2.555E-02 POLB; APEX1
hsa04320 Dorso-ventral axis formation_Homo sapiens_hsa04320 1.100E-02 1.783E-02 MAPK1; EGFR
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 6.541E-04 1.307E-03 MAPK1; BRAF; TP53
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 8.053E-03 1.340E-02 CA2; CA4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 3.412E-04 7.049E-04 CYP1A2; XDH
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; ABCC1; ABCC1; XDH
C00-D49: Neoplasms Glioma C71 PIK3CG; EGFR; EGFR; KDR; APP
C00-D49: Neoplasms Gliosarcoma NA FLT3
C00-D49: Neoplasms Glioblastoma NA FLT3
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; CA1; CA1; ACHE; ADRA2C
NA: NA Geographic retinal atrophy NA APP
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 AR; PIK3CG; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA
C00-D49: Neoplasms Glioblastoma multiforme C71 SRC; ERBB2; EGFR; EGFR
NA: NA GIST NA FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 ESRRA; DRD4
NA: NA Upper abdominal bloating NA ACHE
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 PLA2G1B; ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 ALOX5; FLT3; EGFR
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 ERBB2; KDR
I00-I99: Diseases of the circulatory system Hypertension I10-I16 ADRA2C
C00-D49: Neoplasms Colon cancer C50 FLT3; EGFR
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
E00-E89: Endocrine, nutritional and metabolic diseases Amyloidosis E85 APP
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
C00-D49: Neoplasms Head and neck squamous cell carcinoma C44 EGFR
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
I00-I99: Diseases of the circulatory system Heart failure I50 AR; XDH; ADRA2C
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT; ACHE
NA: NA Angioedema NA PIK3CG
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CAMK2B; MAOA; ACHE; CYP3A4
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2
C00-D49: Neoplasms Hormone refractory prostate cancer C61 AR
E00-E89: Endocrine, nutritional and metabolic diseases Hypogonadism E23.0, E28.3, E29.1 AR
C00-D49: Neoplasms Thyroid cancer C73 BRAF; KDR
C00-D49: Neoplasms Haematological malignancies C81-C86 AURKA
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
C00-D49: Neoplasms Diffuse large B-cell lymphoma C83.3 PIK3CG
H00-H59: Diseases of the eye and adnexa Age related macular degeneration H35.3 APP
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET; PIK3CG; PIK3CG; AURKA; PLK1
K00-K95: Diseases of the digestive system Alcoholic hepatitis K70.1 AR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA; ADRA2C
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MPO; ALOX5
C00-D49: Neoplasms Solid tumours C00-D48 AKT1; MET; SYK; PIK3CG; FLT3; CA9; MMP2; SRC; IGF1R; PTK2; AURKB; AURKA; FLT4; TEK; PDGFRB; HIF1A; MAPK1; MMP9; ERBB2; EGFR; TP53; KDR; KDR; KDR; PLK1; PLK1; TOP2A
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1
NA: NA HIV infections NA AHR
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 AR; IGF1R
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 GAA
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
C00-D49: Neoplasms Female androgenresponsive recurrent mammary cancer C50 AR
L00-L99: Diseases of the skin and subcutaneous tissue Alopecia L65.9 AR
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 PLA2G1B; ALOX5; SYK
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 PLA2G1B; ESRRA; ADRA2C
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1; PIK3CG
C00-D49: Neoplasms Hematological malignancies C81-C86 SYK; SRC; AURKB; TP53
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE; ADRA2C
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 AR; AR; ESRRA; MMP2
C00-D49: Neoplasms Gastric cancer C16 ERBB2; EGFR; EGFR; KDR; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue Fibromyalgia M79.7 ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET
E00-E89: Endocrine, nutritional and metabolic diseases Hypercholesterolemia E78 INSR
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 INSR
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 ALOX5; SYK
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; GSK3B; MAPT; ACHE; ACHE; ACHE; INSR; ADRA2C; APP
C00-D49: Neoplasms AML NA FLT3; KDR
L00-L99: Diseases of the skin and subcutaneous tissue Erythema L51-L54 ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 DRD4
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE
NA: NA Enthesopathy NA PIK3CG
C00-D49: Neoplasms Esophageal cancer C15 EGFR
Z00-Z99: Factors influencing health status and contact with health services Contraception Z30 AR
C00-D49: Neoplasms Advanced prostate cancer C61 AR
C00-D49: Neoplasms Advanced cancers C00-C96 EGFR
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; EGFR; EGFR; EGFR; TP53; KDR; KDR
K00-K95: Diseases of the digestive system Gastrointestinal disease K00-K93 ESRRA; EGFR
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
G00-G99: Diseases of the nervous system G00-G99 Multiple scierosis G35 MPO
C00-D49: Neoplasms Multiple myeloma C90 AHR; SRC; IGF1R
M00-M99: Diseases of the musculoskeletal system and connective tissue Muscle atrophy M62.5 AR
E00-E89: Endocrine, nutritional and metabolic diseases Hunter syndrome E76.1 INSR
E00-E89: Endocrine, nutritional and metabolic diseases Hyperglycaemia in type 2 diabetes E11, R73.9 INSR
C00-D49: Neoplasms Refractory breast cancer C50 EGFR
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 PIK3CG; CYP2C9
C00-D49: Neoplasms Colorectal cancer C18-C21 FLT3; IGF1R; MMP9; ERBB2; EGFR; EGFR; TP53; KDR
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
J00-J99: Diseases of the respiratory system Asthma J45 PLA2G1B; ESRRA; ALOX5; ALOX5; SYK; SYK; ERBB2; ADRA2C
I00-I99: Diseases of the circulatory system Atherosclerosis I70 ALOX5
C00-D49: Neoplasms Prostate cancer C61 AR; AR; PIK3CG; FLT3; FLT4; ERBB2; EGFR; PLK1
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
C00-D49: Neoplasms Advanced breast cancer C50 SRC; CYP19A1
NA: NA Early satiation associated with functional dyspepsia NA ACHE
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Acute myeloid leukemia C92.0 FLT3; FLT3; AURKB; AURKA; TP53; TP53; PLK1
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
C00-D49: Neoplasms HER2-positive urogenital cancer NA ERBB2
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hypoglycemia E16.0-E16.2 INSR
I00-I99: Diseases of the circulatory system Hypotension I95 ADRA2C
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1
C00-D49: Neoplasms Endometrial cancer C54.1 PIK3CG; PIK3CG
E00-E89: Endocrine, nutritional and metabolic diseases Endocrine disease E00-E35 AR
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
NA: NA Edema NA CA2
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 AR; MMP13; ACHE; IGF1R; INSR; CDK1; ADRA2C; ADRA2A
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A PTK2; BRAF; AURKA; TP53
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 CA1; ACHE
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; AXL; IGF1R; IGF1R; PDGFRB; EGFR; EGFR; KDR
C00-D49: Neoplasms Non-small-cell lung cancer NA MMP2; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 ESRRA; INSR
C00-D49: Neoplasms Non-hodgkin's lymphoma C85 SYK; PIK3CG; PIK3CG; ERBB2; PLK1
G00-G99: Diseases of the nervous system G00-G99 Diagnostic imaging G30, I73.9 APP
L00-L99: Diseases of the skin and subcutaneous tissue Diabetic foot ulcer L88-L89 EGFR
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 ADRA2C
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 ALOX5
S00-T88: Injury, poisoning and certain other consequences of external causes Vulnerary S00-T98 EGFR
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 ADRA2C; NPSR1; APP
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
L00-L99: Diseases of the skin and subcutaneous tissue Melasma L81.1 TYR
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 PIK3CG; MMP3
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
K00-K95: Diseases of the digestive system Crohn's disease K50 INSR
A00-B99: Certain infectious and parasitic diseases Cryptosporidium infection A07.2 EGFR
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
E00-E89: Endocrine, nutritional and metabolic diseases Cystic fibrosis E84 AR
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
C00-D49: Neoplasms Myeloid leukemia C92 FLT3
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
C00-D49: Neoplasms Myelodysplastic syndrome D46 TEK; KDR
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA; ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ESRRA; ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1; GSK3B; PDGFRB; INSR
C00-D49: Neoplasms Urethral cancer NA EGFR
K00-K95: Diseases of the digestive system Ulcerative colitis K51 MMP9
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE
C00-D49: Neoplasms Inflammatory breast cancer C50 EGFR
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MPO; PLA2G1B; ALOX5; MMP13; SYK; PIK3CG
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2
C00-D49: Neoplasms CLL NA FLT3
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
NA: NA Hematopoietic stem cell transplantation NA FLT3
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 MPO; MAOA; ACHE; BRAF
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; FLT3; MMP2; EGFR; KDR; PLK1
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
K00-K95: Diseases of the digestive system Peptic ulcer K25-K27 ADRA2C
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 PIK3CG; PIK3CG; INSR; NFKB1
E00-E89: Endocrine, nutritional and metabolic diseases Type 1/2 diabetes E08-E13 INSR
E00-E89: Endocrine, nutritional and metabolic diseases Type 1 diabetes E10 INSR
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 ALOX5
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC; TEK
I00-I99: Diseases of the circulatory system Ischemic stroke I61-I63 MMP3
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; FLT4; KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chronic pain R52.1-R52.2, G89 ERBB2
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 SRC
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 SYK; EGFR
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
C00-D49: Neoplasms Ovarian cancer C56 MMP2; EGFR; EGFR; KDR; KDR; KDR; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis in post-menopausal women M80-M81 AR
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 AR; SRC
C00-D49: Neoplasms Osteosarcoma C40-C41 GSK3B; SRC
L00-L99: Diseases of the skin and subcutaneous tissue Dermatological disease L00-L99 AR; ESRRA
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
C00-D49: Neoplasms Lung cancer C33-C34 MMP2; FLT4; EGFR
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B; ABCC1; ESRRA; ALOX5; PIK3CG; TEK
N00-N99: Diseases of the genitourinary system Prostate hyperplasia N40 AR
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA; TYR
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3
C00-D49: Neoplasms Late-stage non-small cell lung cancer C33-C34 EPHB4
H00-H59: Diseases of the eye and adnexa Choroidal neovascularisation H35 ESRRA
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 ALOX5; MMP13; MMP3; MMP2
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA
H00-H59: Diseases of the eye and adnexa Ocular disease H00-H59 ADRA2C
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 SYK; INSR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Attention deficit hyperactivity disorder F90 ADRA2A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 DRD4
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
S00-T88: Injury, poisoning and certain other consequences of external causes Vascular restinosis following vascular graft surgery T82.858A FLT4
S00-T88: Injury, poisoning and certain other consequences of external causes Contusion S36.220S ADRA2C
H00-H59: Diseases of the eye and adnexa Corneal ulcers H16.0 MMP3
C00-D49: Neoplasms Locally advanced head and neck cancer C07-C14, C32, C33 EGFR
I00-I99: Diseases of the circulatory system Cerebral amyloid angiopathy I68.0 APP
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 EGFR
C00-D49: Neoplasms Ocular cancer C69 APEX1
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 ACHE; CA4; CA2
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 ADRA2C; CA4; CA4
H00-H59: Diseases of the eye and adnexa Macular degeneration H35.3 APP
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; PIK3CG; PIK3CG; CA9; INSR; HIF1A; ERBB2; EGFR; PLK1
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Sexual dysfunction F52 ADRA2A
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 ADRA2C
C00-D49: Neoplasms Metastatic prostate cancer C61 AR
NA: NA Male hypogonadism NA AR
C00-D49: Neoplasms Castration-resistant prostate cancer C61 AR
C00-D49: Neoplasms B-cell lymphoma C85.1 SYK
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Testosterone deficiency E29.1 AR
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
C00-D49: Neoplasms Solid tumors NA BRAF
C00-D49: Neoplasms Melanoma C43 BRAF; EGFR; TYR; KDR; KDR
C00-D49: Neoplasms Malignant tumor C00-C75, C7A, C7B EGFR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cachexia R64 AR; ESRRA
C00-D49: Neoplasms Cancer C00-C96 AR; AKT1; MET; GSK3B; CSNK2A1; SYK; PIK3CG; CA1; FLT3; FLT3; CA9; MMP2; ACHE; SRC; IGF1R; PTK2; BRAF; BRAF; AURKA; FLT4; EPHB4; TEK; HIF1A; CDK1; MAPK1; MMP9; ERBB2; ERBB2; EGFR; NFKB1; PIM1; TP53; KDR; PLK1; APP
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT; ACHE
C00-D49: Neoplasms Metastatic breast cancer C50 PIK3CG; KDR
H00-H59: Diseases of the eye and adnexa Retinal venous occlusion H34.8 ERBB2
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 CAMK2B; AKR1B1; PLA2G1B; ESRRA; ALOX5; SYK; MMP3; TYR
C00-D49: Neoplasms Mesothelioma C45 PTK2
C00-D49: Neoplasms Metastasis C00-C97 AXL
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 AR; KDR
C00-D49: Neoplasms Breast cancer C50 AR; PIK3CG; FLT3; FLT3; CA9; IGF1R; INSR; CYP19A1; CDK1; ERBB2; ERBB2; ERBB2; EGFR; EGFR; EGFR; KDR; KDR; KDR
C00-D49: Neoplasms Brain cancer C71, D33 SRC; EGFR; EGFR
S00-T88: Injury, poisoning and certain other consequences of external causes Brain injury S09.90 PDGFRB; APP
C00-D49: Neoplasms Bladder cancer C67 AR; CYP19A1; ERBB2; EGFR
C00-D49: Neoplasms Metastatic melanoma C43 BRAF; BRAF
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 EGFR; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE; APP
G00-G99: Diseases of the nervous system G00-G99 Mild to moderate alzheimer disease G30 APP
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Beta thalassemia D56.1 HBB
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA1; CA2; MYLK
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Male sexual disorders F52 ADRA2C
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
E00-E89: Endocrine, nutritional and metabolic diseases Male hormonal deficiencies E20-E35 AR
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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Developer & Maintainer:
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