Plant Name: Amomum melegueta
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005215; transporter activity | GO:0015277; kainate selective glutamate receptor activity | 6.163E-13 | 1.491E-09 | GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0023052; signaling | GO:0060079; excitatory postsynaptic potential | 2.798E-12 | 5.540E-09 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044464; cell part | GO:0043204; perikaryon | 8.490E-09 | 1.027E-05 | GRIK2, GRIK3, GRIK5, SMN1, SMN2 |
| MF | GO:0005215; transporter activity | GO:0008381; mechanosensitive ion channel activity | 3.890E-08 | 3.258E-05 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0044456; synapse part | GO:0045211; postsynaptic membrane | 1.778E-07 | 1.335E-04 | GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| MF | Unclassified; | GO:0099600; transmembrane receptor activity | 2.979E-07 | 2.027E-04 | ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR |
| MF | GO:0005215; transporter activity | GO:0098782; mechanosensitived potassium channel activity | 7.897E-07 | 4.777E-04 | GRIK1, GRIK2, GRIK3, GRIK5 |
| CC | GO:0032991; macromolecular complex | GO:0032983; kainate selective glutamate receptor complex | 1.254E-06 | 6.561E-04 | GRIK2, GRIK5 |
| MF | Unclassified; | GO:0004872; receptor activity | 1.544E-06 | 7.473E-04 | ADORA3, GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5, TSHR |
| MF | GO:0005215; transporter activity | GO:0004971; AMPA glutamate receptor activity | 2.507E-06 | 1.137E-03 | GRIA1, GRIA4 |
| CC | GO:0044464; cell part | GO:0043005; neuron projection | 6.386E-06 | 2.528E-03 | GRIA1, GRIA4, GRIK3, GRIK5, SMN1, SMN2 |
| CC | GO:0044456; synapse part | GO:0043195; terminal bouton | 8.802E-06 | 3.305E-03 | GRIK2, GRIK3, GRIK5 |
| BP | GO:0051179; localization | GO:0034220; ion transmembrane transport | 1.130E-05 | 4.035E-03 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| MF | GO:0005488; binding | GO:0030165; PDZ domain binding | 2.360E-05 | 8.029E-03 | GRIA1, GRIK2, GRIK5 |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 2.749E-05 | 9.210E-03 | SMN1, SMN2 |
| MF | GO:0005215; transporter activity | GO:0005234; extracellularly glutamate-gated ion channel activity | 6.433E-16 | 7.004E-12 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
| BP | GO:0009987; cellular process | GO:0035235; ionotropic glutamate receptor signaling pathway | 5.447E-15 | 3.811E-11 | GRIA1, GRIA4, GRIK1, GRIK2, GRIK3, GRIK5 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.484E-12 | 3.858E-11 | GRIA1; GRIK5; ADORA3; GRIK3; GRIK1; GRIK2; TSHR; GRIA4 |
| hsa04724 | Glutamatergic synapse_Homo sapiens_hsa04724 | 4.988E-11 | 6.484E-10 | GRIA1; GRIK5; GRIK3; GRIK1; GRIK2; GRIA4 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 2.578E-04 | 1.950E-03 | GRIA1; TSHR; GRIA4 |
| hsa05033 | Nicotine addiction_Homo sapiens_hsa05033 | 3.000E-04 | 1.950E-03 | GRIA1; GRIA4 |
| hsa05031 | Amphetamine addiction_Homo sapiens_hsa05031 | 8.420E-04 | 4.379E-03 | GRIA1; GRIA4 |
| hsa04713 | Circadian entrainment_Homo sapiens_hsa04713 | 1.683E-03 | 7.055E-03 | GRIA1; GRIA4 |
| hsa04723 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.899E-03 | 7.055E-03 | GRIA1; GRIA4 |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 3.074E-03 | 9.989E-03 | GRIA1; GRIA4 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 5.389E-03 | 1.557E-02 | SMN2; SMN1 |
| hsa03440 | Homologous recombination_Homo sapiens_hsa03440 | 1.869E-02 | 4.860E-02 | BLM |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | GRIA1 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | ADORA3 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | GRIK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | GRIA4 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | GRIA1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1 |
| NA: NA | Hepatitis C virus infection | NA | ADORA3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ADORA3 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | ADORA3 |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | GRIK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | GRIK1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | GRIK1; GRIK1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ADORA3 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1 |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | ADORA3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | GRIK1 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | ADORA3 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Convulsions | R56.0 | GRIA1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| NA: NA | Colour dead tissues | NA | PTPN1 |