Plant Name: Senecio behnii
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 1.232E-06 | 1.412E-03 | ADRA2A, AKR1B1, BCL2, CSNK2A1, ELANE, ESR1, HIF1A, HPGD, MAPK1, MAPK14, PIM1, TSHR |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 1.402E-06 | 1.527E-03 | AKR1B1, ALDH1A1, ALOX15, CYP2C9, CYP3A4, GAA, GFER, HPGD, HSD17B10, KDM4E, MAPK14, PGD |
| BP | GO:0050896; response to stimulus | GO:1901700; response to oxygen-containing compound | 1.003E-05 | 6.827E-03 | AKR1B1, BCL2, BLM, CA3, CA9, CSNK2A1, ELANE, ESR1, HPGD, MAPK1, MAPK14, POLB, TSHR |
| BP | GO:0009987; cellular process | GO:0033554; cellular response to stress | 1.333E-05 | 8.750E-03 | AKR1B1, ALOX15, BCL2, BLM, CA2, CA9, HIF1A, LMNA, MAPK1, MAPK14, MAPT, POLB, RECQL, TDP1 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.687E-20 | 5.103E-16 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 7.983E-19 | 3.476E-15 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.726E-08 | 3.132E-05 | ADRA2A, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3, TSHR |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 5.818E-08 | 9.048E-05 | BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 8.778E-27 | 1.911E-22 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 6.047E-06 | 4.540E-03 | ESR1, ESR2 |
Showing 1 to 10 of 11 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 2.351E-03 | 2.123E-02 | GAA; AKR1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 9.732E-03 | 4.028E-02 | CYP2C9; ALOX15 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 4.537E-05 | 1.690E-03 | CYP2C9; ALOX15; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 5.105E-04 | 9.238E-03 | CYP2C9; ALDH1A1; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 5.410E-26 | 8.061E-24 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.330E-02 | 4.404E-02 | CYP2C9; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.195E-02 | 4.371E-02 | CYP2C9; CYP3A4 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.443E-03 | 2.123E-02 | CYP2C9; FUT7; GAA; ALOX15; ALDH1A1; AKR1B1; PGD; CYP3A4; HSD17B10 |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.413E-02 | 4.480E-02 | MAPK1; MAPK14; MET |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 7.510E-03 | 4.028E-02 | MAPK1; ADRA2C; ADRA2A |
Showing 1 to 10 of 48 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| A00-B99: Certain infectious and parasitic diseases | Septic shock | A41.9 | ELANE |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | ELANE; MAPK14 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | BCL2; HIF1A; CA9 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET |
Showing 1 to 10 of 138 entries