CMAUP Plant Collective Molecular Activities

Plant Name: Rhododendron aureum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.571E-08	2.528E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	2.675E-08	3.641E-05	FABP3, FFAR1, PPARG, PTGS2, TLR2
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	2.585E-07	2.010E-04	NR1I2, PPARA, PPARD, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	5.511E-07	3.077E-04	NR1I2, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	7.112E-07	3.872E-04	ALOX15, HPGD, PTGS2
BP	GO:0051179; localization	GO:0015908; fatty acid transport	9.225E-07	4.783E-04	FABP3, PPARA, PPARD, PPARG
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	1.238E-06	5.992E-04	PTGS1, PTGS2
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	3.712E-06	1.470E-03	ALOX15, PTGS2
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	5.383E-06	1.922E-03	LMNA, PPARD, PTGS2, TERT
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	8.028E-06	2.649E-03	FFAR4, PPARA, PPARD, PPARG
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	8.761E-06	2.847E-03	FABP3, LMNA, PPARD, PPARG, PTGS2, TERT, TLR2
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	1.236E-05	3.686E-03	PPARA, PPARG
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.304E-05	3.838E-03	NR1I2, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	1.699E-05	4.742E-03	FABP3, PPARA, PPARG, TLR2
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	1.852E-05	4.802E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	1.852E-05	4.802E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	1.852E-05	4.802E-03	ALOX15, HPGD
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	1.852E-05	4.802E-03	FABP3, PPARG
BP	GO:0065007; biological regulation	GO:0008217; regulation of blood pressure	2.232E-05	5.719E-03	PPARA, PPARG, PTGS1, PTGS2
MF	Unclassified;	GO:0004872; receptor activity	2.627E-05	6.501E-03	FFAR1, FFAR4, HPGD, NR1I2, PPARA, PPARD, PPARG, TLR2, TSHR
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	2.952E-05	7.218E-03	NR1I2, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0045600; positive regulation of fat cell differentiation	4.000E-05	9.266E-03	PPARD, PPARG, PTGS2
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	4.192E-05	9.596E-03	NR1I2, PPARA, PPARD, PPARG
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	4.231E-05	9.596E-03	ALDH1A1, ALOX15, HPGD, PPARD, PPARG, PTGS1, PTGS2
BP	GO:0050896; response to stimulus	GO:0047484; regulation of response to osmotic stress	4.436E-05	9.959E-03	ABCB1, PTGS2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	6.963E-13	4.178E-11	FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	3.883E-07	1.165E-05	FABP4; PTGS2; TSHR; PTGS1
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	4.189E-05	8.378E-04	ALOX15; PTGS2; PTGS1
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	2.436E-04	3.654E-03	ALOX15; PTGS2; PTGS1
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	2.895E-03	3.474E-02	PTGS2; TLR2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
NA: NA	Rheumatold arthritis	NA	PTGS1; PTGS2; PTGS2; PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; PTGS2; PTGS2; PTGS2
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2; PPARG; PPARG
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
NA: NA	Dyslipidemia	NA	PPARD
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1; PTGS2; PTGS2; PTGS2; PTGS2
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1; PTGS2; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS1; FAAH; PTGS2
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2; PPARG
C00-D49: Neoplasms	Cancer	C00-C96	ABCB1; TLR2; PTGS2
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD; PPARG
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1; PPARD; PTGS2; PPARG; PPARG
NA: NA	Joint and muscular pain	NA	PTGS2
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
C00-D49: Neoplasms	Breast cancer	C50	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
C00-D49: Neoplasms	Prostate cancer	C61	TLR2; TERT
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2
C00-D49: Neoplasms	Liver cancer	C22	TERT
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2; PPARG
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	FAAH
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
J00-J99: Diseases of the respiratory system	Asthma	J45	PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2; PTGS2
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD; NR1I2
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	ABCB1
C00-D49: Neoplasms	Multiple myeloma	C90	TERT
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1; PPARG
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ABCB1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
NA: NA	Miosis during ocular surgery	NA	PTGS1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2; TERT; PTGS2
C00-D49: Neoplasms	Ovarian cancer	C56	ABCB1; TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS1; FAAH; PTGS2; PTGS2; PTGS2; PTGS2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT; PPARG
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD; PPARD; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD; PPARG
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	ABCB1; PTGS2
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
C00-D49: Neoplasms	Solid tumours	C00-D48	ABCB1; TLR2
C00-D49: Neoplasms	Melanoma	C43	TLR2; TERT
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1; PTGS2; PTGS2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases