CMAUP Plant Collective Molecular Activities

Plant Name: Platycodon grandiflorus

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	4.763E-13	2.593E-09	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	4.763E-13	2.593E-09	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0005488; binding	GO:0051378; serotonin binding	1.193E-11	3.247E-08	HTR1A, HTR2B, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	3.996E-10	7.910E-07	HTR1A, HTR5A, HTR7
MF	Unclassified;	GO:0004872; receptor activity	6.736E-08	9.167E-05	DRD1, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7, THRB
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	3.297E-07	3.590E-04	DRD1, HTR1A, HTR2B, HTR7
BP	Unclassified;	GO:0042310; vasoconstriction	3.625E-07	3.759E-04	HTR1A, HTR2B, HTR7
MF	Unclassified;	GO:0099600; transmembrane receptor activity	4.849E-07	4.224E-04	DRD1, HCAR2, HTR1A, HTR2B, HTR5A, HTR6, HTR7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.050E-11	1.785E-10	HTR6; HTR7; THRB; HTR1A; HTR2B; DRD1; HTR5A
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	1.240E-09	1.054E-08	HTR6; HTR7; HTR1A; HTR2B; HTR5A
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	1.357E-08	7.690E-08	HTR6; HTR7; HTR2B; DRD1; HTR5A
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	1.906E-06	8.100E-06	HCAR2; HTR6; HTR1A; DRD1
hsa04540	Gap junction_Homo sapiens_hsa04540	8.418E-04	2.862E-03	HTR2B; DRD1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
NA: NA	Social phobia	NA	HTR1A
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6
NA: NA	Episode	NA	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; HTR1A; HTR1A; HTR6; DRD1
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1
NA: NA	Peripheral sensory neuropathies	NA	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A
NA: NA	Anxiety disorders	NA	HTR1A
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR1A; DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR1A; DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR1A; HTR6; DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR1A; HTR6; HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2B; HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2
NA: NA	Bulimia nervosa	NA	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	HTR2B; HTR1A
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR7; HTR1A; HTR1A; HCAR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A; HTR1A
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1; HCAR2
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A
NA: NA	Cervical dystonia	NA	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	HTR6
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A; HTR1A
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR1A; HTR1A; HTR6; HTR6; HTR6
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR6
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HCAR2; THRB
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	HTR1A; DRD1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB
NA: NA	Schizoaffective disorder	NA	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HTR6; DRD1
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	HTR1A; DRD1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR1A; DRD1
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases