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Plant Name: Ehretia dicksonii




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
GPR35; ADRA2C; ADRA2A; DRD4;
Peptide receptor (family A GPCR)
NPSR1; CXCR1; NMUR2;
Enzyme_unclassified
AMY1A;AMY1B;AMY1C; RECQL; TDP1; PLA2G1B; BLM; APOBEC3G; CTDSP1; TERT; PKM; PIK3CG; PIK3R1; GLO1; HPGD; PGD; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; NOX4; USP2; PYGL; APEX1; POLB;
Hydrolase
ACHE; GAA;
Protein Phosphatase
DUSP3;
Miscellaneous ion channel
BCL2;
Isomerase
TOP2A;
Protein Kinase
AKT1; MET; CAMK2B; GSK3B; CSNK2A1; DAPK1; SYK; NEK2; FLT3; NEK6; MYLK; SRC; IGF1R; PTK2; BRAF; AURKB; AURKA; DYRK1A; FLT4; EPHB4; MAP3K8; TEK; PDGFRB; INSR; PLK4; CDK1; MAPK1; MAPK14; EGFR; ERBB2; PIM1; NUAK1; ALK; AXL; KDR; PLK1; PKN1;
Lyase
CA12; CA14; CA5B; CA3; CA7; CA5A; CA1; CA9; CA13; CA4; CA6; CA2;
Nuclear hormone receptor subfamily 3 group C
AR;
Nuclear hormone receptor subfamily 3 group B
ESRRA;
Nuclear hormone receptor subfamily 1 group H
NR1H3;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; TYR; XDH;
Serine protease
F10; F2;
Metallo protease
MMP13; MMP2; MMP3; MMP14; MMP9;
Aspartic protease
BACE1;
Transcription Factor
AHR; STAT6; HIF1A; NFKB1; TP53;
DNA methyltransferase
DNMT1;
Transferase
FUT7;
ATP-binding cassette
ABCC1; ABCB1; ABCG2;
SLC superfamily of solute carriers
SLC22A6; SLCO1B1; SLCO1B3;
Unclassified
SMAD3; LMNA; MAPT; HBB; THPO; APP; HSPA1A;
Methyl-lysine/arginine binding protein
L3MBTL1;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP1A2; CYP19A1; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein ClassGene IDProtein NameUniprot IDTarget ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCB1 P-glycoprotein 1 P08183 CHEMBL4302
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Showing 1 to 10 of 133 entries
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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO TypeGO CategoryEnriched GO Termsp-ValueAdjusted p-ValueEnriched Genes
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 3.206E-12 4.533E-10 AXL, EGFR, ERBB2, F10, INSR, MET, NOX4, PDGFRB, PIK3CG, PIK3R1, PTK2, SRC, TEK, THPO
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 2.139E-11 2.723E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 5.188E-09 4.849E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP Unclassified; GO:0032846; positive regulation of homeostatic process 6.778E-09 6.124E-07 AURKB, CA2, CA7, EGFR, F2, HIF1A, MAPK1, MAPK14, NEK2, NPSR1, NR1H3, PLA2G1B, SYK
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.179E-08 1.011E-06 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 3.386E-08 2.741E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 3.470E-08 2.799E-06 EGFR, IGF1R, INSR, KDR, PTK2, SRC, SYK
BP Unclassified; GO:0032844; regulation of homeostatic process 3.706E-08 2.977E-06 ADRA2A, AURKB, BCL2, CA2, CA7, EGFR, F2, HIF1A, KDR, MAPK1, MAPK14, NEK2, NPSR1, NR1H3, PLA2G1B, SRC, SYK
BP GO:0009987; cellular process GO:0070374; positive regulation of ERK1 and ERK2 cascade 1.398E-07 1.004E-05 ALOX15, APP, BRAF, EGFR, FLT4, KDR, NOX4, PDGFRB, SRC, TEK, THPO
BP GO:0051179; localization GO:0042307; positive regulation of protein import into nucleus 4.287E-07 2.812E-05 APP, CDK1, EGFR, F2, MAPK1, MAPK14, PIK3R1, SMAD3
Showing 1 to 10 of 154 entries
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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway IDPathway Namep-ValueAdjusted p-ValueEnriched Genes
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.739E-02 2.724E-02 GAA; AKR1B1
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 1.232E-07 6.143E-07 HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 4.463E-04 9.062E-04 CYP1A2; XDH
hsa00350 Tyrosine metabolism_Homo sapiens_hsa00350 2.327E-02 3.535E-02 MAOA; TYR
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 1.503E-04 3.323E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa00500 Starch and sucrose metabolism_Homo sapiens_hsa00500 3.769E-05 9.260E-05 AMY1A; AMY1B; GAA; AMY1C; PYGL
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 1.971E-07 9.339E-07 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 7.527E-10 7.132E-09 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa00620 Pyruvate metabolism_Homo sapiens_hsa00620 2.985E-02 4.499E-02 PKM; GLO1
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 5.040E-06 1.567E-05 CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
Showing 1 to 10 of 132 entries
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Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease CategoryDisease NameICD10 CodeLinked Targets
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 ABCB1; PIK3CG; CYP2C9
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
A00-B99: Certain infectious and parasitic diseases Cryptosporidium infection A07.2 EGFR
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
Showing 1 to 10 of 291 entries
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Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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