CMAUP Plant Collective Molecular Activities

Plant Name: Delphinium nuttallianum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.726E-08	3.132E-05	ADRA2A, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3, TSHR
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.818E-08	9.048E-05	BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.778E-27	1.911E-22	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	1.232E-06	1.412E-03	ADRA2A, AKR1B1, BCL2, CSNK2A1, ELANE, ESR1, HIF1A, HPGD, MAPK1, MAPK14, PIM1, TSHR
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.402E-06	1.527E-03	AKR1B1, ALDH1A1, ALOX15, CYP2C9, CYP3A4, GAA, GFER, HPGD, HSD17B10, KDM4E, MAPK14, PGD
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	6.047E-06	4.540E-03	ESR1, ESR2
BP	GO:0050896; response to stimulus	GO:1901700; response to oxygen-containing compound	1.003E-05	6.827E-03	AKR1B1, BCL2, BLM, CA3, CA9, CSNK2A1, ELANE, ESR1, HPGD, MAPK1, MAPK14, POLB, TSHR
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	1.333E-05	8.750E-03	AKR1B1, ALOX15, BCL2, BLM, CA2, CA9, HIF1A, LMNA, MAPK1, MAPK14, MAPT, POLB, RECQL, TDP1
MF	GO:0005488; binding	GO:0043167; ion binding	1.433E-05	8.918E-03	ACHE, ALOX15, BLM, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP2C9, CYP3A4, ELANE, ESR1, ESR2, GFER, HPGD, KDM4E, MAPK1, MAPK14, MET, NMUR2, PIM1, POLB, RECQL
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.687E-20	5.103E-16	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	7.983E-19	3.476E-15	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	5.410E-26	8.061E-24	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	2.665E-05	1.324E-03	MAPK1; MAPK14; ESR1; ESR2
hsa04976	Bile secretion_Homo sapiens_hsa04976	2.521E-05	1.324E-03	SLCO1B1; CA2; SLCO1B3; CYP3A4
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.005E-04	2.995E-03	PIM1; BCL2; MAPK1; MAPK14
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	1.232E-04	3.059E-03	MAPK1; MAPK14; HIF1A; ESR1; MET
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	4.537E-05	1.690E-03	CYP2C9; ALOX15; CYP3A4
hsa05211	Renal cell carcinoma_Homo sapiens_hsa05211	5.339E-04	9.238E-03	MAPK1; MET; HIF1A
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	5.105E-04	9.238E-03	CYP2C9; ALDH1A1; CYP3A4
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	5.580E-04	9.238E-03	MAPK1; MET; HIF1A
hsa04520	Adherens junction_Homo sapiens_hsa04520	7.462E-04	1.112E-02	CSNK2A1; MAPK1; MET
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	1.731E-03	2.123E-02	MAPK1; ESR1; ESR2
hsa04725	Cholinergic synapse_Homo sapiens_hsa04725	2.400E-03	2.123E-02	ACHE; BCL2; MAPK1
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	2.443E-03	2.123E-02	CYP2C9; FUT7; GAA; ALOX15; ALDH1A1; AKR1B1; PGD; CYP3A4; HSD17B10
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	1.939E-03	2.123E-02	BCL2; MAPK1; HIF1A
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	2.462E-03	2.123E-02	CYP2C9; ALOX15; MAPK1
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	2.854E-03	2.123E-02	BCL2; MAPK1; MAPK14
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	2.854E-03	2.123E-02	MAPK1; ESR1; HIF1A
hsa04722	Neurotrophin signaling pathway_Homo sapiens_hsa04722	2.993E-03	2.123E-02	BCL2; MAPK1; MAPK14
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	4.342E-03	2.941E-02	NMUR2; ADRA2C; ADRA2A; TSHR
hsa04210	Apoptosis_Homo sapiens_hsa04210	4.613E-03	2.988E-02	LMNA; BCL2; MAPK1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	2.993E-03	2.123E-02	BCL2; MAPK1; MAPK14
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	5.550E-03	3.308E-02	PIM1; BCL2; MAPK1; MET
hsa04261	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	5.383E-03	3.308E-02	BCL2; MAPK1; MAPK14
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	7.510E-03	4.028E-02	MAPK1; ADRA2C; ADRA2A
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.382E-03	1.872E-02	CA2; CA4
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	7.634E-03	4.028E-02	MAPK1; MAPT; HSD17B10
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	2.351E-03	2.123E-02	GAA; AKR1B1
hsa05152	Tuberculosis_Homo sapiens_hsa05152	8.939E-03	4.028E-02	BCL2; MAPK1; MAPK14
hsa05202	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	9.215E-03	4.028E-02	HPGD; MET; ELANE
hsa05169	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.258E-02	4.371E-02	CSNK2A1; BCL2; MAPK14
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	8.276E-03	4.028E-02	PIM1; MAPK1
hsa04510	Focal adhesion_Homo sapiens_hsa04510	1.258E-02	4.371E-02	BCL2; MAPK1; MET
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	9.137E-03	4.028E-02	MAPK1; HIF1A
hsa05014	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	6.672E-03	3.824E-02	BCL2; MAPK14
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	1.497E-02	4.646E-02	BCL2; MAPK1; HIF1A; MET
hsa04370	VEGF signaling pathway_Homo sapiens_hsa04370	9.432E-03	4.028E-02	MAPK1; MAPK14
hsa04015	Rap1 signaling pathway_Homo sapiens_hsa04015	1.413E-02	4.480E-02	MAPK1; MAPK14; MET
hsa04621	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	8.276E-03	4.028E-02	MAPK1; MAPK14
hsa04664	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.162E-02	4.371E-02	MAPK1; MAPK14
hsa05210	Colorectal cancer_Homo sapiens_hsa05210	9.732E-03	4.028E-02	BCL2; MAPK1
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	9.732E-03	4.028E-02	CYP2C9; ALOX15
hsa05120	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.162E-02	4.371E-02	MAPK14; MET
hsa05218	Melanoma_Homo sapiens_hsa05218	1.261E-02	4.371E-02	MAPK1; MET
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.195E-02	4.371E-02	CYP2C9; CYP3A4
hsa05131	Shigellosis_Homo sapiens_hsa05131	1.066E-02	4.291E-02	MAPK1; MAPK14
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	1.330E-02	4.404E-02	MAPK1; MAPK14
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.330E-02	4.404E-02	CYP2C9; CYP3A4
hsa05133	Pertussis_Homo sapiens_hsa05133	1.400E-02	4.480E-02	MAPK1; MAPK14

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
J00-J99: Diseases of the respiratory system	Asthma	J45	ELANE; ADRA2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	ELANE; ELANE
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2
NA: NA	Inflammatory diseases	NA	MAPK14
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ELANE; MAPK14
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1; ADRA2C; ADRA2A; ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET
NA: NA	Myocardial ischaemia-reperfusion injury	NA	ELANE
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET
C00-D49: Neoplasms	Leukemia	C90-C95	BCL2; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE; MAPT
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2; HIF1A; CA9
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C; CA4; CA4
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; AKR1B1; ADRA2C; ACHE
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
NA: NA	Postmenopausal disorder	NA	ESR1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
NA: NA	Edema	NA	CA2
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	ELANE; ELANE; ELANE; MAPK14
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
NA: NA	Menopausal disorder	NA	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	MAPK14; MAPK14
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
J00-J99: Diseases of the respiratory system	Mucolytic	J00-J99	ELANE
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
C00-D49: Neoplasms	Multiple myeloma	C90	BCL2
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
NA: NA	Upper abdominal bloating	NA	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
C00-D49: Neoplasms	Renal cancer	C64	CA9
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	BCL2; MAPK14
C00-D49: Neoplasms	Prostate cancer	C61	BCL2; ESR1
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
J00-J99: Diseases of the respiratory system	Pulmonary emphysema	J43	ELANE
J00-J99: Diseases of the respiratory system	Pulmonary disease	J00-J99	ELANE
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; ACHE; CA4
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
NA: NA	Acute respiratory distress syndrome	NA	ELANE; ELANE; ELANE; MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; MET; CA9; MAPK1
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
J00-J99: Diseases of the respiratory system	Bronchiectasis	J47, Q33.4	ELANE
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ELANE; MAPK14; AKR1B1
NA: NA	Rheumatold arthritis	NA	MAPK14
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
C00-D49: Neoplasms	Breast cancer	C50	BCL2; CA9; ESR1; ESR1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ELANE; ELANE; MAPK14
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ELANE
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
NA: NA	Gonorrheal vaginitis	NA	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; ADRA2C
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
C00-D49: Neoplasms	Cancer	C00-C96	BCL2; BCL2; HIF1A; MET; CA1; CA9; MAPK1; MAPK14; ESR1; ESR1; PIM1; ACHE; CSNK2A1
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases