CMAUP Plant Collective Molecular Activities

Plant Name: Scutellaria seleriana

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.297E-11	9.356E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.249E-09	3.810E-05	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.115E-08	4.966E-05	AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, HSD11B1, NPC1, NR1H4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.497E-08	5.431E-05	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.483E-07	8.823E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	9.178E-07	1.052E-03	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.088E-06	6.431E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	9.415E-06	6.714E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	9.558E-06	6.714E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.415E-06	6.714E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	9.558E-06	6.714E-03	ADRA2A, ADRA2C
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	9.558E-06	6.714E-03	GPBAR1, NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	7.425E-11	9.503E-09	CA12; CA1; CA7; CA9; CA13
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	3.117E-06	1.995E-04	HSD11B1; CYP1A2; CYP1A1; CYP1B1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	7.850E-06	2.652E-04	HSD11B1; CYP1A2; CYP1A1; CYP1B1
hsa04520	Adherens junction_Homo sapiens_hsa04520	8.288E-06	2.652E-04	PTPN1; MAPK1; ACP1; PTPRF
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.247E-05	3.193E-04	HSD11B1; CYP1A2; CYP1A1; CYP1B1
hsa00380	Tryptophan metabolism_Homo sapiens_hsa00380	4.640E-05	8.484E-04	CYP1A2; CYP1A1; CYP1B1
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	1.930E-05	4.117E-04	AKR1B10; GAA; AKR1B1
hsa05206	MicroRNAs in cancer_Homo sapiens_hsa05206	1.736E-03	1.799E-02	ABCC1; CYP1B1; MAPK1; CDC25B
hsa04910	Insulin signaling pathway_Homo sapiens_hsa04910	1.827E-03	1.799E-02	PTPN1; MAPK1; PTPRF
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	3.076E-03	2.812E-02	MAPK1; ADRA2C; ADRA2A
hsa05216	Thyroid cancer_Homo sapiens_hsa05216	1.173E-03	1.668E-02	PAX8; MAPK1
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.173E-03	1.668E-02	PLA2G1B; CYP1A2
hsa01100	Metabolic pathways_Homo sapiens_hsa01100	5.010E-03	3.772E-02	HSD11B1; AKR1B10; PLA2G1B; GAA; CYP1A2; CYP1A1; AKR1B1
hsa04913	Ovarian steroidogenesis_Homo sapiens_hsa04913	3.457E-03	2.950E-02	CYP1A1; CYP1B1
hsa00040	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.806E-03	1.799E-02	AKR1B10; AKR1B1
hsa00051	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.428E-03	1.799E-02	AKR1B10; AKR1B1
hsa00561	Glycerolipid metabolism_Homo sapiens_hsa00561	4.782E-03	3.772E-02	AKR1B10; AKR1B1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	5.775E-03	4.107E-02	CYP1A2; CYP1A1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1; ADRA2C
C00-D49: Neoplasms	Breast cancer	C50	CA9
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; CA9
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C; ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C; PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; ACHE; ACHE; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1; AKR1B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; CA1; CDC25B; CA9; ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; AKR1B1; ADRA2C; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C; PLA2G1B
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; ADRA2A; ACHE
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1; ABCC1; ABCC1
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
C00-D49: Neoplasms	Renal cancer	C64	CA9
NA: NA	Colour dead tissues	NA	PTPN1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B; ABCC1
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1; ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases