CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.278E-31	1.149E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	Unclassified;	GO:0044259; multicellular organismal macromolecule metabolic process	3.040E-06	3.678E-03	HIF1A, MMP1, MMP2, MMP9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.066E-06	4.427E-03	CA2, CA7
BP	Unclassified;	GO:0044236; multicellular organism metabolic process	7.000E-06	6.977E-03	HIF1A, MMP1, MMP2, MMP9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.917E-24	3.176E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.440E-22	7.838E-19	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.818E-14	8.767E-11	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PTPN1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.260E-30	2.771E-28	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa05219	Bladder cancer_Homo sapiens_hsa05219	1.376E-05	5.849E-04	MMP1; MMP2; MMP9
hsa05200	Pathways in cancer_Homo sapiens_hsa05200	7.529E-05	2.133E-03	MMP1; MMP2; HIF1A; MMP9; NFKB1
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	1.571E-03	2.670E-02	MMP2; HIF1A; MMP9
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.154E-04	6.702E-03	CA2; CA4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CA1; CA9; MMP9; NFKB1; MMP2
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; CA9; MMP9; MMP2
C00-D49: Neoplasms	Breast cancer	C50	CA9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MMP1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP1
C00-D49: Neoplasms	Ovarian cancer	C56	MMP2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP2
C00-D49: Neoplasms	Renal cancer	C64	CA9
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; NFKB1
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
NA: NA	Colour dead tissues	NA	PTPN1
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Colorectal cancer	C18-C21	MMP9
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Actinidia polygama

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases