Plant Name: Lupinus formosus
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 9.008E-15 | 1.961E-10 | CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 7.512E-10 | 2.337E-06 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 7.512E-10 | 2.337E-06 | CYP1A2, CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 3.442E-09 | 5.765E-06 | CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS1 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.057E-08 | 1.129E-05 | AKR1B1, AKR1B10, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.760E-07 | 1.369E-04 | CYP1A2, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.934E-06 | 1.138E-03 | CYP1A2, CYP2C19, CYP2C9 |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 2.512E-06 | 1.436E-03 | CASP1, CASP7, MAPT, XDH |
| BP | GO:0051179; localization | GO:1904823; purine nucleobase transmembrane transport | 4.066E-06 | 1.967E-03 | SLC28A1, SLC28A3 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 4.066E-06 | 1.967E-03 | CYP2D6, CYP3A4 |
Showing 1 to 10 of 19 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 7.783E-04 | 2.835E-03 | AKR1B10; AKR1B1 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 6.144E-04 | 2.410E-03 | AKR1B10; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 5.396E-04 | 2.293E-03 | AKR1B10; AKR1B1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.011E-03 | 5.893E-03 | CYP1A2; CYP3A4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.262E-05 | 7.154E-05 | CYP1A2; XDH |
| hsa00240 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 6.428E-03 | 1.639E-02 | CDA; TK1 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 2.080E-03 | 5.893E-03 | AKR1B10; AKR1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 7.092E-07 | 6.028E-06 | CYP2C9; ALOX15; CYP2C19; PTGS1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.472E-10 | 7.510E-09 | CYP2C9; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 5.539E-05 | 2.825E-04 | CYP2C9; CYP1A2; CYP3A4 |
Showing 1 to 10 of 22 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| A00-B99: Certain infectious and parasitic diseases | Adult varicella zoster virus infection | B02 | TK1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; CA9; TK1; CDA |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | TK1 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TK1 |
| C00-D49: Neoplasms | Prostate cancer | C61 | TK1 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PTGS1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; CA9; TK1 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
Showing 1 to 10 of 54 entries