Plant Name: Solanum chilense
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.450E-09 | 1.578E-05 | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, HSD11B1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 2.595E-08 | 1.449E-04 | ACP1, CDC25B, PTPN1, PTPN2, PTPRF |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 8.120E-08 | 2.947E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 8.942E-07 | 1.770E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.189E-06 | 1.992E-03 | CYP1A1, CYP1A2, CYP1B1 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 1.189E-06 | 1.992E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 2.459E-06 | 3.103E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 2.459E-06 | 3.103E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:0051716; cellular response to stimulus | 3.774E-06 | 4.081E-03 | AKR1B1, CYP1A1, CYP1A2, CYP1B1, NR1H4, PLA2G1B, POLB, PTPN1, PTPRF, RECQL, RORC |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 4.916E-06 | 4.460E-03 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 4.916E-06 | 4.460E-03 | CYP1A1, CYP1A2 |
| BP | GO:0008152; metabolic process | GO:0017144; drug metabolic process | 5.689E-06 | 4.770E-03 | ABCC1, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:1901700; response to oxygen-containing compound | 8.941E-06 | 6.953E-03 | AKR1B1, CYP1A1, CYP1A2, CYP1B1, NR1H4, PLA2G1B, POLB, RORC |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 9.408E-06 | 7.064E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.219E-05 | 8.846E-03 | NR1H4, PTPN1, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.890E-07 | 7.560E-06 | HSD11B1; CYP1A2; CYP1A1; CYP1B1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 4.808E-07 | 9.616E-06 | HSD11B1; CYP1A2; CYP1A1; CYP1B1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 7.687E-07 | 1.025E-05 | HSD11B1; CYP1A2; CYP1A1; CYP1B1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 5.923E-06 | 5.923E-05 | CYP1A2; CYP1A1; CYP1B1 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 3.812E-05 | 3.050E-04 | PTPN1; ACP1; PTPRF |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 5.430E-04 | 2.172E-03 | HSD11B1; AKR1B10; PLA2G1B; CYP1A2; CYP1A1; AKR1B1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.062E-04 | 1.867E-03 | PLA2G1B; CYP1A2 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 9.135E-04 | 3.322E-03 | CYP1A1; CYP1B1 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 4.733E-04 | 2.104E-03 | AKR1B10; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 3.279E-04 | 1.867E-03 | AKR1B10; AKR1B1 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.270E-03 | 4.233E-03 | AKR1B10; AKR1B1 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 2.242E-03 | 6.406E-03 | ABCC1; CYP1B1; CDC25B |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 3.734E-04 | 1.867E-03 | AKR1B10; AKR1B1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.539E-03 | 4.735E-03 | CYP1A2; CYP1A1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 4.254E-03 | 1.123E-02 | PTPN1; PTPRF |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 6.821E-03 | 1.605E-02 | PTPN1; PTPRF |
| hsa04977 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 2.139E-02 | 4.689E-02 | ABCC1 |
| hsa00592 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 2.227E-02 | 4.689E-02 | PLA2G1B |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.492E-03 | 1.123E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | ABCC1; ABCC1; AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1 |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1; AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDC25B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1; PLA2G1B |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | ABCC1; PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |