CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Breast cancer	C50	KDR; KDR; KDR
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR
C00-D49: Neoplasms	Thyroid cancer	C73	KDR
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; KDR
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; AURKA; KDR
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR
C00-D49: Neoplasms	Gastric cancer	C16	KDR; KDR
C00-D49: Neoplasms	Renal cancer	C64	KDR
C00-D49: Neoplasms	Melanoma	C43	KDR; KDR
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKB; AURKA; KDR; KDR; KDR
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; KDR
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA
C00-D49: Neoplasms	Liver cancer	C22	KDR
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR
C00-D49: Neoplasms	Glioma	C71	KDR
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; AURKA
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR; KDR
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR
C00-D49: Neoplasms	AML	NA	KDR
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; KDR; KDR; KDR
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Albizia amara

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases