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Plant Name: Strychnos triplinervia




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 2.582E-05 1.162E-03 CYP2A6; ALDH1A1; CYP3A4
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 5.978E-05 1.345E-03 CYP2A6; AKR1B10; PLA2G1B; ALDH1A1; AKR1B1; CYP3A4; PTGS1
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 3.062E-04 3.361E-03 PLA2G1B; CYP3A4
hsa00040 Pentose and glucuronate interconversions_Homo sapiens_hsa00040 4.733E-04 3.550E-03 AKR1B10; AKR1B1
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 3.279E-04 3.361E-03 AKR1B10; AKR1B1
hsa00983 Drug metabolism - other enzymes_Homo sapiens_hsa00983 7.735E-04 4.972E-03 CYP2A6; CYP3A4
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 1.145E-03 6.305E-03 TSHR; PTGS1
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 3.734E-04 3.361E-03 AKR1B10; AKR1B1
hsa00561 Glycerolipid metabolism_Homo sapiens_hsa00561 1.270E-03 6.305E-03 AKR1B10; AKR1B1
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 1.401E-03 6.305E-03 PLA2G1B; PTGS1
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 1.732E-03 6.701E-03 CYP2A6; CYP3A4
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 1.936E-03 6.701E-03 CYP2A6; CYP3A4
hsa04976 Bile secretion_Homo sapiens_hsa04976 1.832E-03 6.701E-03 NR1H4; CYP3A4
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 2.435E-03 7.826E-03 CYP2A6; CYP3A4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 4.492E-03 1.348E-02 CYP2A6
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 PTGS1
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 PTGS1
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 PTGS1
K00-K95: Diseases of the digestive system Ulcerative colitis K51 PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 PTPN1; PTPN1; GPBAR1
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 PTPN1
N00-N99: Diseases of the genitourinary system Dysmenorrhea N94.4-N94.6 PTGS1
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 PLA2G1B
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 PLA2G1B
J00-J99: Diseases of the respiratory system Asthma J45 PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 GPBAR1
NA: NA Rheumatold arthritis NA PTGS1
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1
NA: NA Colour dead tissues NA PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 PTPN1; AKR1B1
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 PTGS1
S00-T88: Injury, poisoning and certain other consequences of external causes Postoperative inflammation T81 PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 PTGS1; AKR1B1
C00-D49: Neoplasms Cancer C00-C96 CDC25B
E00-E89: Endocrine, nutritional and metabolic diseases Dietary shortage E40-E46 PTGS1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR
NA: NA Miosis during ocular surgery NA PTGS1
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 PTGS1; PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 PLA2G1B; AKR1B1
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
C00-D49: Neoplasms Colorectal cancer C18-C21 PTGS1
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 PLA2G1B
C00-D49: Neoplasms Thyroid cancer C73 TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CYP3A4
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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