CMAUP Plant Collective Molecular Activities

Plant Name: Dasymaschalon blumei

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	HSD11B1; PTPN1; PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HSD11B1; PTPN1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
NA: NA	Colour dead tissues	NA	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGES; MAPT
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	HSD11B1; HSD11B1; PTPN1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases