CMAUP Plant Collective Molecular Activities

Plant Name: Garcinia polyantha

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.782E-09	3.881E-06	BLM, CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, ESR1, ESR2
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	1.608E-06	2.694E-03	ESR1, ESR2
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.821E-06	6.758E-03	CA2, CA7
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	9.266E-06	9.535E-03	CSNK2A1, HIF1A, MAPT
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	9.634E-06	9.535E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	9.634E-06	9.535E-03	CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.886E-24	2.153E-19	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.370E-18	1.492E-14	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.671E-17	3.632E-13	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	3.506E-23	4.277E-21	CA12; CA1; CA3; CA2; CA5A; CA7; CA6; CA9; CA14
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	6.170E-06	3.764E-04	CYP2C9; ALOX15; CYP3A4
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	9.720E-05	3.953E-03	MAPK1; ESR1; ESR2
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	2.500E-04	7.625E-03	MAPK1; ESR1; ESR2
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	3.594E-04	8.516E-03	CYP2C9; ALOX15; MAPK1
hsa04919	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	4.188E-04	8.516E-03	MAPK1; ESR1; HIF1A
hsa05010	Alzheimer's disease_Homo sapiens_hsa05010	1.169E-03	2.037E-02	MAPK1; MAPT; HSD17B10
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	2.010E-03	2.599E-02	MAPK1; HIF1A; ESR1
hsa05221	Acute myeloid leukemia_Homo sapiens_hsa05221	2.295E-03	2.599E-02	PIM1; MAPK1
hsa04150	mTOR signaling pathway_Homo sapiens_hsa04150	2.540E-03	2.599E-02	MAPK1; HIF1A
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.709E-03	2.599E-02	CYP2C9; ALOX15
hsa05211	Renal cell carcinoma_Homo sapiens_hsa05211	3.064E-03	2.599E-02	MAPK1; HIF1A
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.973E-03	2.599E-02	CYP2C9; CYP3A4
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	3.156E-03	2.599E-02	MAPK1; HIF1A
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.343E-03	2.599E-02	CYP2C9; CYP3A4
hsa04933	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	7.023E-03	4.045E-02	PIM1; MAPK1
hsa04520	Adherens junction_Homo sapiens_hsa04520	3.834E-03	2.599E-02	CSNK2A1; MAPK1
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.734E-03	2.599E-02	CYP2C9; CYP3A4
hsa04976	Bile secretion_Homo sapiens_hsa04976	3.536E-03	2.599E-02	CA2; CYP3A4
hsa05231	Choline metabolism in cancer_Homo sapiens_hsa05231	7.023E-03	4.045E-02	MAPK1; HIF1A
hsa04066	HIF-1 signaling pathway_Homo sapiens_hsa04066	7.294E-03	4.045E-02	MAPK1; HIF1A
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	4.686E-03	3.009E-02	CYP2C9; CYP3A4

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Breast cancer	C50	CA9; ESR1; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; ESR1
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CA1; CA9; MAPK1; ESR1; ESR1; PIM1; CSNK2A1
J00-J99: Diseases of the respiratory system	Bronchiectasis	J47, Q33.4	ELANE
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
C00-D49: Neoplasms	Prostate cancer	C61	ESR1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
J00-J99: Diseases of the respiratory system	Pulmonary emphysema	J43	ELANE
J00-J99: Diseases of the respiratory system	Pulmonary disease	J00-J99	ELANE
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
NA: NA	Postmenopausal disorder	NA	ESR1
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	ELANE; ELANE; ELANE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
C00-D49: Neoplasms	Renal cancer	C64	CA9
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ELANE; ELANE
NA: NA	Acute respiratory distress syndrome	NA	ELANE; ELANE; ELANE
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ELANE
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ELANE
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
J00-J99: Diseases of the respiratory system	Mucolytic	J00-J99	ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; CA9; MAPK1
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	ELANE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1
NA: NA	Myocardial ischaemia-reperfusion injury	NA	ELANE
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ELANE
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
J00-J99: Diseases of the respiratory system	Asthma	J45	ELANE
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
NA: NA	Gonorrheal vaginitis	NA	ESR1
NA: NA	Menopausal disorder	NA	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	ELANE; ELANE
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases