Plant Name: Zanthoxylum avicennae
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 2.674E-13 | 5.823E-09 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.330E-11 | 3.625E-07 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 9.562E-11 | 6.940E-07 | CA1, CA12, CA13, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 4.627E-13 | 1.481E-11 | CA12; CA1; CA7; CA9; CA13 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.828E-04 | 2.924E-03 | CYP1A2; CYP2C19 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 6.615E-04 | 6.541E-03 | CASP7; CASP1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 9.229E-04 | 6.541E-03 | CYP1A2; ALDH1A1 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.039E-03 | 6.541E-03 | CYP1A2; CYP2C19 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 1.226E-03 | 6.541E-03 | CASP7; CASP1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.464E-03 | 6.691E-03 | CYP1A2; CYP2C19 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 4.190E-03 | 1.490E-02 | CASP7; LMNA |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 8.888E-03 | 2.585E-02 | CYP1A2; ALDH1A1; CYP2C19; HSD17B10 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 5.973E-03 | 1.911E-02 | CASP7; HSD17B10 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.495E-03 | 1.398E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |