CMAUP Plant Collective Molecular Activities

Plant Name: Euphorbia aellenii

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ELANE
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	ELANE; ELANE; ELANE
NA: NA	Acute respiratory distress syndrome	NA	ELANE; ELANE; ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	ELANE; ELANE
J00-J99: Diseases of the respiratory system	Mucolytic	J00-J99	ELANE
J00-J99: Diseases of the respiratory system	Bronchiectasis	J47, Q33.4	ELANE
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
J00-J99: Diseases of the respiratory system	Asthma	J45	ELANE
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ELANE; ELANE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	ELANE
NA: NA	Myocardial ischaemia-reperfusion injury	NA	ELANE
J00-J99: Diseases of the respiratory system	Pulmonary disease	J00-J99	ELANE
J00-J99: Diseases of the respiratory system	Pulmonary emphysema	J43	ELANE
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ELANE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ELANE

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases