Plant Name: Hyacinthus orientalis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.043E-14 | 2.224E-10 | CA1, CA12, CA14, CA2, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.214E-12 | 1.835E-08 | CA1, CA12, CA2, CA7, CA9 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 7.235E-07 | 1.750E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 3.614E-06 | 7.155E-03 | CA1, CA2 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.456E-17 | 3.170E-13 | CA1, CA12, CA14, CA2, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.921E-17 | 5.549E-16 | CA12; CA1; CA2; CA7; CA9; CA14 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 4.602E-04 | 3.477E-03 | ALDH1A1; CYP3A4 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 5.490E-04 | 3.477E-03 | CA2; CYP3A4 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.049E-02 | 4.838E-02 | AGL; ALDH1A1; CYP3A4 |
| hsa04966 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.342E-02 | 4.563E-02 | CA2 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.144E-02 | 4.563E-02 | CA2 |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.766E-02 | 4.838E-02 | AGL |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.441E-02 | 4.563E-02 | CYP3A4 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 2.277E-02 | 4.838E-02 | CYP3A4 |
| hsa04971 | Gastric acid secretion_Homo sapiens_hsa04971 | 3.640E-02 | 4.838E-02 | CA2 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 3.398E-02 | 4.838E-02 | CYP3A4 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.863E-02 | 4.838E-02 | CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.591E-02 | 4.838E-02 | CYP3A4 |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 3.640E-02 | 4.838E-02 | LMNA |
| hsa05414 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 4.411E-02 | 4.930E-02 | LMNA |
| hsa05410 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 4.074E-02 | 4.838E-02 | LMNA |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 4.026E-02 | 4.838E-02 | CYP3A4 |
| hsa04972 | Pancreatic secretion_Homo sapiens_hsa04972 | 4.699E-02 | 4.960E-02 | CA2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| NA: NA | Edema | NA | CA2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |