CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	3.660E-09	7.969E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	4.017E-08	4.374E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	2.417E-07	1.754E-03	CYP2C19, CYP2C9, CYP3A4, NPC1, NR0B1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.084E-06	5.903E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.121E-06	7.699E-03	CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.561E-06	7.968E-03	CYP2C19, CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	5.977E-07	1.793E-05	CYP2C9; CYP3A4; CYP2C19
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	8.456E-06	1.268E-04	CYP2C9; CYP3A4; CYP2C19
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	1.423E-05	1.423E-04	CYP2C9; CYP3A4; CYP2C19
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	6.117E-04	4.033E-03	CYP2C9; CYP2C19
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	6.722E-04	4.033E-03	CYP2C9; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	8.470E-04	4.235E-03	CYP2C9; CYP3A4
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	1.978E-03	8.475E-03	CYP2C9; CYP2C19
hsa03013	RNA transport_Homo sapiens_hsa03013	4.586E-03	1.720E-02	SMN2; SMN1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	NR3C1
S00-T88: Injury, poisoning and certain other consequences of external causes	Skin allergies	T78.4	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	NR3C1
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	NR3C1
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; NR3C1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	NR3C1
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	NR3C1
H60-H95: Diseases of the ear and mastoid process	Otitis externa	H60	NR3C1
G00-G99: Diseases of the nervous system G00-G99	Duchenne muscular dystrophy	G71.0	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	NR3C1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	NR3C1
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1
NA: NA	Corticosteroid-responsive inflammation	NA	NR3C1
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	NR3C1
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	NR3C1; NR3C1; NR3C1
J00-J99: Diseases of the respiratory system	Asthma	J45	NR3C1; NR3C1; NR3C1; NR3C1
S00-T88: Injury, poisoning and certain other consequences of external causes	Spinal cord injury	S14, S24, S34	NR3C1
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	NR3C1
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; NR3C1
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
L00-L99: Diseases of the skin and subcutaneous tissue	Eczema	L20-L30	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A
NA: NA	Non-infectious rhinitis	NA	NR3C1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Hyptis verticillata

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases