Plant Name: Avrainvillea nigricans
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| GPBAR1; | |
| PTPN1; PTPN2; ACP1; PTPRF; | |
| RECQL; GLA; FAAH; TDP1; TERT; GLO1; HSD11B1; ALOX12; AKR1B1; HSD17B10; ALOX15; AKR1B10; NOX4; TNKS; PARP1; TNKS2; POLB; CD38; | |
| GSK3B; FLT3; | |
| CA2; CA12; CA1; CA9; CA3; CA5B; CA7; CA5A; CA4; CA6; | |
| PPARA; PPARD; PPARG; | |
| RORC; | |
| NR1H4; | |
| ALOX5; MAOA; XDH; | |
| KDM4E; | |
| MMP12; MMP2; MMP9; | |
| TLR2; | |
| HIF1A; TP53; | |
| ABCG2; | |
| LMNA; FABP5; APP; TTR; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
Showing 1 to 10 of 60 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 1.484E-09 | 1.154E-06 | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, GSK3B, HSD11B1, HSD17B10, KDM4E, MAOA, NOX4, PPARD, PPARG, XDH |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 7.680E-08 | 2.883E-05 | AKR1B1, AKR1B10, APP, CYP1A1, CYP1A2, CYP1B1, HSD11B1, NR1H4, PPARD |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 5.174E-07 | 1.657E-04 | CYP1A1, POLB, PPARG, TP53 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 2.657E-06 | 5.903E-04 | ALOX12, ALOX15, ALOX5, TLR2 |
| BP | GO:0008152; metabolic process | GO:1901564; organonitrogen compound metabolic process | 3.444E-06 | 7.353E-04 | ABCG2, ACP1, AKR1B1, APP, CD38, CYP1A1, CYP1A2, FLT3, GLA, GLO1, GSK3B, HIF1A, HSD17B10, KDM4E, MAOA, MMP12, MMP2, MMP9, NOX4, NR1H4, PARP1, POLB, PPARA, PPARD, PPARG, PTPN1, PTPN2, PTPRF, TLR2, TNKS, TNKS2, TP53, TTR, XDH |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 3.540E-06 | 7.483E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0032502; developmental process | GO:0048856; anatomical structure development | 5.774E-06 | 1.143E-03 | AKR1B1, ALOX15, APP, CA2, CYP1A1, CYP1A2, CYP1B1, FABP5, FLT3, GSK3B, HIF1A, HSD11B1, LMNA, MMP9, POLB, PPARA, PPARD, PPARG, PTPRF, RORC, SMN1, SMN2, TLR2, TP53, TSHR |
| BP | GO:0008152; metabolic process | GO:0001523; retinoid metabolic process | 9.506E-06 | 1.729E-03 | AKR1B10, CYP1A1, CYP1B1, PPARD, TTR |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 9.810E-06 | 1.729E-03 | ALOX12, ALOX15 |
| BP | GO:0009987; cellular process | GO:2001242; regulation of intrinsic apoptotic signaling pathway | 1.043E-05 | 1.817E-03 | HIF1A, MMP9, PARP1, PTPN1, PTPN2, TP53 |
Showing 1 to 10 of 64 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 5.393E-03 | 2.816E-02 | AKR1B10; AKR1B1 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 4.279E-03 | 2.413E-02 | AKR1B10; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.034E-04 | 1.617E-03 | AKR1B10; AKR1B1; GLA |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.937E-05 | 8.283E-04 | HSD11B1; CYP1A2; CYP1A1; CYP1B1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 9.097E-05 | 1.603E-03 | CYP1A2; XDH |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 6.592E-06 | 4.647E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 7.772E-04 | 6.849E-03 | AKR1B10; AKR1B1; GLA |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 8.983E-04 | 7.450E-03 | ALOX5; ALOX15; ALOX12 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.523E-03 | 2.070E-02 | CYP1A2; ALOX15 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 6.128E-22 | 8.641E-20 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9 |
Showing 1 to 10 of 38 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | ALOX5; MMP12; FAAH |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | GSK3B; HIF1A; TP53; CA1; FLT3; FLT3; CA9; PARP1; MMP2; MMP9; APP; CD38; TLR2 |
| C00-D49: Neoplasms | Breast cancer | C50 | FLT3; FLT3; CA9; TERT |
| C00-D49: Neoplasms | Recurrent epithelial ovarian or primary peritoneal cancer | C78 | PARP1 |
Showing 1 to 10 of 145 entries