Plant Name: Vernonia profuga
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0023052; signaling | GO:0007271; synaptic transmission, cholinergic | 1.072E-11 | 2.594E-08 | CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 4.532E-08 | 6.167E-05 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 4.997E-07 | 6.045E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 6.647E-07 | 6.893E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 3.374E-06 | 2.099E-03 | CYP1A1, CYP1A2 |
| BP | GO:0032501; multicellular organismal process | GO:0046541; saliva secretion | 5.621E-06 | 3.060E-03 | CHRM1, CHRM3 |
| BP | GO:0008152; metabolic process | GO:0033013; tetrapyrrole metabolic process | 1.081E-05 | 5.117E-03 | ABCC1, CYP1A1, CYP1A2 |
| BP | GO:0008152; metabolic process | GO:0050665; hydrogen peroxide biosynthetic process | 1.572E-05 | 6.864E-03 | CYP1A1, CYP1A2 |
| BP | Unclassified; | GO:0003056; regulation of vascular smooth muscle contraction | 2.020E-05 | 7.997E-03 | CHRM1, CHRM3 |
| BP | GO:0032501; multicellular organismal process | GO:0090257; regulation of muscle system process | 2.330E-05 | 8.989E-03 | CHRM1, CHRM2, CHRM3, LMNA |
Showing 1 to 10 of 20 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.027E-05 | 5.993E-05 | CYP1A2; CYP1A1; CYP1B1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.745E-03 | 1.092E-02 | CYP1A2 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 3.316E-06 | 2.902E-05 | CYP1A2; CYP1A1; CYP1B1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.154E-02 | 4.711E-02 | CYP1A2 |
| hsa00760 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 2.154E-02 | 4.711E-02 | NT5E |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.063E-03 | 3.381E-03 | CYP1A2; CYP1A1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.057E-05 | 1.028E-04 | CYP1A2; CYP1A1; CYP1B1 |
| hsa04020 | Calcium signaling pathway_Homo sapiens_hsa04020 | 8.016E-06 | 5.611E-05 | CHRM2; CHRM3; CHRM1; CHRM5 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 4.042E-04 | 1.572E-03 | CHRM2; CHRM1; TSHR |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 5.305E-10 | 1.857E-08 | CHRM2; CHRM3; CHRM1; CHRM4; CHRM5; TAAR1; TSHR |
Showing 1 to 10 of 16 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | CHRM1; CHRM1; CHRM4; CHRM4; CHRM5 |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | CHRM1; CHRM3; CHRM4 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CHRM4 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | CHRM1; CHRM5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | CHRM4 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Dementia | F01-F07 | CHRM1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Amnesia | F04 | CHRM5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | CHRM1; CHRM1; CHRM1; CHRM5 |
Showing 1 to 10 of 74 entries