CMAUP Plant Collective Molecular Activities

Plant Name: Magnolia acuminata

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.131E-08	2.462E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0051179; localization	GO:0015850; organic hydroxy compound transport	7.131E-08	5.176E-04	NPC1, SLC6A2, SLC6A3, SLCO1B1, SLCO1B3
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.240E-07	6.748E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.792E-06	7.804E-03	CYP2C19, CYP2C9, CYP3A4, NPC1, NR0B1
MF	GO:0005215; transporter activity	GO:0005330; dopamine:sodium symporter activity	2.186E-06	7.933E-03	SLC6A2, SLC6A3
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	3.332E-06	9.068E-03	CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.370E-06	9.515E-03	CYP2C9, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	1.839E-06	6.803E-05	CYP2C9; CYP3A4; CYP2C19
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.581E-05	3.469E-04	CYP2C9; CYP3A4; CYP2C19
hsa04976	Bile secretion_Homo sapiens_hsa04976	2.813E-05	3.469E-04	SLCO1B1; SLCO1B3; CYP3A4
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	4.334E-05	4.009E-04	CYP2C9; CYP3A4; CYP2C19
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.248E-03	8.452E-03	CYP2C9; CYP2C19
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.371E-03	8.452E-03	CYP2C9; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.725E-03	9.117E-03	CYP2C9; CYP3A4
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	4.001E-03	1.851E-02	CYP2C9; CYP2C19
hsa03013	RNA transport_Homo sapiens_hsa03013	9.187E-03	3.777E-02	SMN2; SMN1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
I00-I99: Diseases of the circulatory system	Heart failure	I50	SLC6A2
NA: NA	Corticosteroid-responsive inflammation	NA	NR3C1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	NR3C1
G00-G99: Diseases of the nervous system G00-G99	Ataxia telangiectasia	G11.3	NR3C1
J00-J99: Diseases of the respiratory system	Asthma	J45	PTAFR; NR3C1; NR3C1; NR3C1; NR3C1
C00-D49: Neoplasms	Neuroendocrine cancer	C7A	SLC6A2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	SLC6A2
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NR3C1
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	PTAFR
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	PTAFR
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	NR3C1
S00-T88: Injury, poisoning and certain other consequences of external causes	Spinal cord injury	S14, S24, S34	NR3C1
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; PTAFR
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
S00-T88: Injury, poisoning and certain other consequences of external causes	Skin allergies	T78.4	NR3C1
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; NR3C1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cancer pain	R52, G89	SLC6A2
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	PTAFR
NA: NA	Non-infectious rhinitis	NA	NR3C1
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	NR3C1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	NR3C1
H60-H95: Diseases of the ear and mastoid process	Otitis externa	H60	NR3C1
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	NR3C1
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTAFR
E00-E89: Endocrine, nutritional and metabolic diseases	Xerophthalmia	E50.6-E50.7	NR3C1
G00-G99: Diseases of the nervous system G00-G99	Brain ischaemia	G45.9, I67.8	PTAFR
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Thrombocytopenia	D69.6, P61.0	PTAFR
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	SLC6A2; PTAFR
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	NR3C1; NR3C1; NR3C1
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	NR3C1
H00-H59: Diseases of the eye and adnexa	Ocular allergy	H00-H59	PTAFR
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	SLC6A2; SLC6A2
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	PTAFR
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	PTAFR
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	PTAFR
G00-G99: Diseases of the nervous system G00-G99	Duchenne muscular dystrophy	G71.0	NR3C1
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PTAFR
C00-D49: Neoplasms	Neuroblastoma	C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7	SLC6A2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	NR3C1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTAFR; NR3C1
H00-H59: Diseases of the eye and adnexa	Conjunctivitis	H10	PTAFR
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	SLC6A2; SLC6A2; SLC6A2; SLC6A2; NR3C1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	SLC6A2; CYP3A4; NR3C1
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
E00-E89: Endocrine, nutritional and metabolic diseases	Cushing's disease	E24.0	NR3C1
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PTAFR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	SLC6A2
L00-L99: Diseases of the skin and subcutaneous tissue	Eczema	L20-L30	NR3C1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	SLC6A2

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases