Plant Name: Libanothamnus occultus
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 8.300E-08 | 1.807E-03 | CA12, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.293E-06 | 7.527E-03 | CA12, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0003824; catalytic activity | 6.941E-07 | 7.527E-03 | ABCG2, ALDH1A1, CA12, CA7, CA9, CASP1, CASP7, CYP1A2, GFER, HSD17B10, NOX4, PLG |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.117E-07 | 3.016E-06 | CA12; CA7; CA9 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 4.815E-04 | 6.033E-03 | CASP7; CASP1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 6.722E-04 | 6.033E-03 | CYP1A2; ALDH1A1 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 8.938E-04 | 6.033E-03 | CASP7; CASP1 |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 4.743E-03 | 1.829E-02 | CASP1; PLG |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 4.380E-03 | 1.829E-02 | CASP7; HSD17B10 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.997E-03 | 1.618E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Excessive bleeding | R58 | PLG |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | PLG |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Excessive postoperative bleeding | R58 | PLG |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | PLG; PLG; PLG |
| NA: NA | Acute coronary thrombosis | NA | PLG |
| NA: NA | Heart attack | NA | PLG |
| N00-N99: Diseases of the genitourinary system | Menorrhagia | N92.0 | PLG |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| H00-H59: Diseases of the eye and adnexa | Macular degeneration | H35.3 | PLG |
| H60-H95: Diseases of the ear and mastoid process | Otitis media | H65-H67 | PLG |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | PLG |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; PLG |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
| I00-I99: Diseases of the circulatory system | Bleeding | I74, I80-I82 | PLG |
| I00-I99: Diseases of the circulatory system | Pulmonary embolism | I26 | PLG |
| I00-I99: Diseases of the circulatory system | Chronic angina | I20 | PLG |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | PLG |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |