Plant Name: Baccharis solieri
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 6.989E-06 | 7.247E-03 | CA2, CA7 |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 7.600E-06 | 7.522E-03 | CASP1, CASP7, MAPT, XDH |
| BP | GO:0065007; biological regulation | GO:0010817; regulation of hormone levels | 1.018E-05 | 9.639E-03 | ACHE, ADRA2A, ADRA2C, ALDH1A1, HIF1A, NR1H4, SLCO1B1 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 9.519E-18 | 8.553E-14 | CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.587E-16 | 1.562E-12 | CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9 |
| CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.157E-08 | 2.100E-05 | ADRA2A, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.556E-06 | 3.092E-03 | CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0004938; alpha2-adrenergic receptor activity | 6.989E-06 | 7.247E-03 | ADRA2A, ADRA2C |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 6.914E-23 | 1.506E-18 | CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9 |
Showing 1 to 9 of 9 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.169E-05 | 8.531E-04 | CYP1A2; XDH |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 8.611E-04 | 1.452E-02 | CYP1A2; ALOX15 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 4.266E-03 | 3.815E-02 | CYP1A2; ALDH1A1 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.451E-22 | 2.892E-20 | CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14; CA13 |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.967E-03 | 2.901E-02 | MAPK1; ADRA2C; ADRA2A |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 3.647E-03 | 3.815E-02 | MAPK1; HIF1A |
| hsa04621 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 3.298E-03 | 3.815E-02 | CASP1; MAPK1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 5.396E-04 | 1.061E-02 | CA2; CA4 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 3.726E-06 | 2.198E-04 | SLCO1B1; CA2; SLCO1B3; NR1H4 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.110E-04 | 3.275E-03 | CASP7; MAPK1; MAPT; HSD17B10 |
Showing 1 to 10 of 14 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; CA9; MAPK1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; CA1; CA9; MAPK1; ACHE |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; CA9 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic nephropathy | E11.21 | ADRA2C |
Showing 1 to 10 of 62 entries