CMAUP Plant Collective Molecular Activities

Plant Name: Trifolium dubium

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	BCHE; ACHE;
Enzyme_unclassified	TDP1; PIK3CA; PIK3CB; PKM; GFER; NQO2; USP2;
Lyase	CA2; CA1; CA12; CA9; CA13; CA5B; CA5A; CA7; CA3; CA14; CA4; CA6;
Nuclear hormone receptor subfamily 3 group A	ESR1;
Oxidoreductase	PTGS1; MAOA; PTGS2;
Transcription Factor	HIF1A; TP53;
SLC superfamily of solute carriers	SLC6A2;
Unclassified	HTT; LMNA; APP;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP3A4; CYP1A2; CYP2D6;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PIK3CA	PI3-kinase p110-alpha subunit	P42336	CHEMBL4005
Enzyme_unclassified	PIK3CB	PI3-kinase p110-beta subunit	P42338	CHEMBL3145
Enzyme_unclassified	PKM	Pyruvate kinase isozymes M1/M2	P14618	CHEMBL1075189
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
SLC superfamily of solute carriers	SLC6A2	Norepinephrine transporter	P23975	CHEMBL222
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	APP	Beta amyloid A4 protein	P05067	CHEMBL2487

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.343E-13	3.249E-10	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	4.842E-11	8.787E-08	BCHE, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, NQO2, PTGS1
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.849E-10	3.097E-07	CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, NQO2, TP53
MF	GO:0005488; binding	GO:0020037; heme binding	5.060E-09	5.509E-06	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PTGS1, PTGS2
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	6.231E-09	6.167E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	6.231E-09	6.167E-06	CYP1A2, CYP2C9, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.586E-08	2.166E-05	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.806E-08	2.182E-05	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	4.622E-07	2.960E-04	APP, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, ESR1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.659E-07	3.423E-04	CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.349E-07	4.329E-04	CYP1A2, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.187E-31	4.761E-27	CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0065007; biological regulation	GO:0098771; inorganic ion homeostasis	3.258E-06	1.448E-03	APP, CA12, CA2, CA7, ESR1, HIF1A, HTT, PIK3CB, TP53
MF	GO:0003824; catalytic activity	GO:0004666; prostaglandin-endoperoxide synthase activity	3.769E-06	1.548E-03	PTGS1, PTGS2
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	3.769E-06	1.548E-03	ACHE, BCHE
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	4.846E-06	1.851E-03	CA2, CA7, HIF1A, HTT, PIK3CB, PTGS2
BP	GO:0007610; behavior	GO:0007612; learning	6.693E-06	2.429E-03	APP, BCHE, HIF1A, HTT, PTGS2
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.116E-06	3.254E-03	CYP1A2, CYP2C19, CYP2C9
CC	GO:0044464; cell part	GO:0044444; cytoplasmic part	1.034E-05	3.575E-03	ACHE, APP, BCHE, CA1, CA13, CA2, CA3, CA4, CA5A, CA5B, CA7, CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, ESR1, GFER, HIF1A, HTT, LMNA, MAOA, NQO2, PIK3CA, PIK3CB, PKM, PTGS1, PTGS2, SMN1, SMN2, TP53, USP2
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.129E-05	3.725E-03	CYP2D6, CYP3A4
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.129E-05	3.725E-03	CA2, CA7
BP	GO:0065007; biological regulation	GO:0030003; cellular cation homeostasis	1.179E-05	3.832E-03	APP, CA2, CA7, ESR1, HIF1A, HTT, PIK3CB, TP53
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.211E-05	3.877E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.474E-05	4.521E-03	CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	3.423E-05	9.317E-03	APP, CA2, CYP1A2, HIF1A, PTGS2, TP53
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.776E-24	1.064E-19	CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.007E-22	1.092E-18	CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	SLC6A2
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	SLC6A2; MAOA; MAOA
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53; PTGS1
G00-G99: Diseases of the nervous system G00-G99	Diagnostic imaging	G30, I73.9	APP
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS1
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2; PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA; ACHE
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS2; PTGS2; PTGS2; PTGS2; ESR1; SLC6A2; ACHE; PTGS1; PKM
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2
NA: NA	Miosis during ocular surgery	NA	PTGS1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; PTGS2; PTGS2; PTGS2
NA: NA	Rheumatold arthritis	NA	PTGS2; PTGS2; PTGS2; PTGS1
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
NA: NA	Postmenopausal disorder	NA	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; ACHE; CA4
C00-D49: Neoplasms	Prostate cancer	C61	ESR1
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	SLC6A2
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	SLC6A2
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Renal cancer	C64	CA9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; TP53; PIK3CA; PIK3CB; CA9; PKM
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
I00-I99: Diseases of the circulatory system	Cerebral amyloid angiopathy	I68.0	APP
C00-D49: Neoplasms	Neuroendocrine cancer	C7A	SLC6A2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
H00-H59: Diseases of the eye and adnexa	Macular degeneration	H35.3	APP
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	SLC6A2; SLC6A2; SLC6A2; SLC6A2; MAOA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	SLC6A2
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	SLC6A2; SLC6A2
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
I00-I99: Diseases of the circulatory system	Heart failure	I50	SLC6A2
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Brain injury	S09.90	APP
C00-D49: Neoplasms	Breast cancer	C50	CA9; ESR1; ESR1; NQO2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2; PTGS2
J00-J99: Diseases of the respiratory system	Asthma	J45	PTGS2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
NA: NA	Joint and muscular pain	NA	PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2; HIF1A; TP53; PIK3CA; PIK3CB; CA1; CA9; ESR1; ESR1; NQO2; ACHE; APP
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cancer pain	R52, G89	SLC6A2
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; PTGS1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2; CYP2D6
NA: NA	Gonorrheal vaginitis	NA	ESR1
NA: NA	Geographic retinal atrophy	NA	APP
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Amyloidosis	E85	APP
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE; APP
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	APP
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53; PIK3CA
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2
NA: NA	Edema	NA	CA2
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; SLC6A2; MAOA; ACHE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2; MAOA; ACHE; ACHE; ACHE; APP
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS2; PTGS2; PTGS2; PTGS2; ESR1; PTGS1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS2; PTGS1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1; APP
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2; PTGS2; MAOA; PTGS1
C00-D49: Neoplasms	Neuroblastoma	C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7	SLC6A2
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA
H00-H59: Diseases of the eye and adnexa	Age related macular degeneration	H35.3	APP
NA: NA	Menopausal disorder	NA	ESR1
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	PIK3CB
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2
C00-D49: Neoplasms	Glioma	C71	APP

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases