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Plant Name: Ginkgo semen




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
DRD4; ADORA2A; ADRA2C; ADRA2A; ADRA2B; HTR2C; DRD3;
Peptide receptor (family A GPCR)
OPRD1; TSHR; NPSR1; CXCR1; NMUR2;
Enzyme_unclassified
ALPL; RECQL; PLA2G1B; TDP1; CTDSP1; TERT; PKM; PIK3R1; GLO1; HPGD; PGD; MPO; HSD17B1; AKR1B1; HSD17B2; HSD17B10; ALOX15; ALDH1A1; ALOX12; NOX4; TNKS; PARP1; TNKS2; PYGL; POLB;
Protein Phosphatase
PTPN1;
Hydrolase
ACHE; GAA;
Histone deacetylase
HDAC3;
Glycine receptor
GLRA2; GLRA1;
Transient receptor potential channel
TRPV1;
Miscellaneous ion channel
BCL2;
Protein Kinase
AKT1; MET; CAMK2B; CSNK2A1; DAPK1; AXL; NEK2; FLT3; PKN1; SRC; IGF1R; PTK2; AURKB; DYRK1A; GSK3B; CDK1; MAPK1; MAPK14; PIM1; NUAK1; ALK; NEK6; KDR;
Lyase
CA5A; CA3; CA14; CA5B; CA12; CA7; CA4; CA6; CA2; CA9; CA1;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARG; PPARD;
Nuclear hormone receptor subfamily 3 group C
AR;
Nuclear hormone receptor subfamily 3 group B
ESRRA;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; PTGS1; ALOX5; TYR; XDH;
Metallo protease
MMP13; MMP3; MMP2; MMP14; MMP9;
Aspartic protease
BACE1;
Toll-like and Il-1 receptors
TLR2;
Transcription Factor
AHR; STAT6; HIF1A; NFKB1; TP53;
DNA methyltransferase
DNMT1;
Bromodomain
EP300;
Endoplasmic reticular retrotranslocon family
VCP;
ATP-binding cassette
ABCC1; ABCB1; ABCG2;
SLC superfamily of solute carriers
SLC22A8; SLC22A6; SLCO1B3; SLCO1B1;
Unclassified
LMNA; FABP2; FABP4; MCL1; MAPT; FABP3; FABP5; THPO; SAE1; RAB9A; NPC1; APP;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP2D6; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCB1 P-glycoprotein 1 P08183 CHEMBL4302
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Bromodomain EP300 Histone acetyltransferase p300 Q09472 CHEMBL3784
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2D6 Cytochrome P450 2D6 P10635 CHEMBL289
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
DNA methyltransferase DNMT1 DNA (cytosine-5)-methyltransferase 1 P26358 CHEMBL1993
Endoplasmic reticular retrotranslocon family VCP Transitional endoplasmic reticulum ATPase P55072 CHEMBL1075145
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified ALPL Alkaline phosphatase, tissue-nonspecific isozyme P05186 CHEMBL5979
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified PLA2G1B Phospholipase A2 group 1B P04054 CHEMBL4426
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Q9GZU7 CHEMBL1795098
Enzyme_unclassified TERT Telomerase reverse transcriptase O14746 CHEMBL2916
Enzyme_unclassified PKM Pyruvate kinase isozymes M1/M2 P14618 CHEMBL1075189
Enzyme_unclassified PIK3R1 PI3-kinase p85-alpha subunit P27986 CHEMBL2506
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Enzyme_unclassified PGD 6-phosphogluconate dehydrogenase P52209 CHEMBL3404
Enzyme_unclassified MPO Myeloperoxidase P05164 CHEMBL2439
Enzyme_unclassified HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified TNKS Tankyrase-1 O95271 CHEMBL6164
Enzyme_unclassified PARP1 Poly [ADP-ribose] polymerase-1 P09874 CHEMBL3105
Enzyme_unclassified TNKS2 Tankyrase-2 Q9H2K2 CHEMBL6154
Enzyme_unclassified PYGL Liver glycogen phosphorylase P06737 CHEMBL2568
Glycine receptor GLRA2 Glycine receptor subunit alpha-2 P23416 CHEMBL5871
Glycine receptor GLRA1 Glycine receptor subunit alpha-1 P23415 CHEMBL5845
Histone deacetylase HDAC3 Histone deacetylase 3 O15379 CHEMBL1829
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP13 Matrix metalloproteinase 13 P45452 CHEMBL280
Metallo protease MMP3 Matrix metalloproteinase 3 P08254 CHEMBL283
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP14 Matrix metalloproteinase 14 P50281 CHEMBL3869
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Miscellaneous ion channel BCL2 Apoptosis regulator Bcl-2 P10415 CHEMBL4860
Nuclear hormone receptor subfamily 1 group C PPARA Peroxisome proliferator-activated receptor alpha Q07869 CHEMBL239
Nuclear hormone receptor subfamily 1 group C PPARG Peroxisome proliferator-activated receptor gamma P37231 CHEMBL235
Nuclear hormone receptor subfamily 1 group C PPARD Peroxisome proliferator-activated receptor delta Q03181 CHEMBL3979
Nuclear hormone receptor subfamily 3 group B ESRRA Estrogen-related receptor alpha P11474 CHEMBL3429
Nuclear hormone receptor subfamily 3 group C AR Androgen Receptor P10275 CHEMBL1871
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase PTGS1 Cyclooxygenase-1 P23219 CHEMBL221
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase TYR Tyrosinase P14679 CHEMBL1973
Peptide receptor (family A GPCR) OPRD1 Delta opioid receptor P41143 CHEMBL236
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A P25024 CHEMBL4029
Peptide receptor (family A GPCR) NMUR2 Neuromedin-U receptor 2 Q9GZQ4 CHEMBL1075144
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase CAMK2B CaM kinase II beta Q13554 CHEMBL4121
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase DAPK1 Death-associated protein kinase 1 P53355 CHEMBL2558
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 P51955 CHEMBL3835
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase PKN1 Protein kinase N1 Q16512 CHEMBL3384
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Q13627 CHEMBL2292
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Kinase MAPK14 MAP kinase p38 alpha Q16539 CHEMBL260
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 Q9HC98 CHEMBL4309
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Phosphatase PTPN1 Protein-tyrosine phosphatase 1B P18031 CHEMBL335
SLC superfamily of solute carriers SLC22A8 Solute carrier family 22 member 8 Q8TCC7 CHEMBL1641348
SLC superfamily of solute carriers SLC22A6 Solute carrier family 22 member 6 Q4U2R8 CHEMBL1641347
SLC superfamily of solute carriers SLCO1B3 Solute carrier organic anion transporter family member 1B3 Q9NPD5 CHEMBL1743121
SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 Q9Y6L6 CHEMBL1697668
Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor P21917 CHEMBL219
Small molecule receptor (family A GPCR) ADORA2A Adenosine A2a receptor P29274 CHEMBL251
Small molecule receptor (family A GPCR) ADRA2C Alpha-2c adrenergic receptor P18825 CHEMBL1916
Small molecule receptor (family A GPCR) ADRA2A Alpha-2a adrenergic receptor P08913 CHEMBL1867
Small molecule receptor (family A GPCR) ADRA2B Alpha-2b adrenergic receptor P18089 CHEMBL1942
Small molecule receptor (family A GPCR) HTR2C Serotonin 2c (5-HT2c) receptor P28335 CHEMBL225
Small molecule receptor (family A GPCR) DRD3 Dopamine D3 receptor P35462 CHEMBL234
Toll-like and Il-1 receptors TLR2 Toll-like receptor 2 O60603 CHEMBL4163
Transcription Factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Transcription Factor STAT6 Signal transducer and activator of transcription 6 P42226 CHEMBL5401
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Transient receptor potential channel TRPV1 Vanilloid receptor Q8NER1 CHEMBL4794
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified FABP2 Fatty acid binding protein intestinal P12104 CHEMBL4879
Unclassified FABP4 Fatty acid binding protein adipocyte P15090 CHEMBL2083
Unclassified MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Q07820 CHEMBL4361
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified FABP3 Fatty acid binding protein muscle P05413 CHEMBL3344
Unclassified FABP5 Fatty acid binding protein epidermal Q01469 CHEMBL3674
Unclassified THPO Thrombopoietin P40225 CHEMBL1293256
Unclassified SAE1 SUMO-activating enzyme subunit 1 Q9UBE0 CHEMBL1615388
Unclassified RAB9A Ras-related protein Rab-9A P51151 CHEMBL1293294
Unclassified NPC1 Niemann-Pick C1 protein O15118 CHEMBL1293277
Unclassified APP Beta amyloid A4 protein P05067 CHEMBL2487
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
MF GO:0005488; binding GO:0019825; oxygen binding 4.419E-13 1.119E-10 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, NOX4
MF GO:0005488; binding GO:0008270; zinc ion binding 1.281E-12 3.100E-10 AR, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, EP300, ESRRA, GLO1, GLRA1, MMP13, MMP14, MMP2, MMP3, MMP9, PARP1, PPARA, PPARD, PPARG, PTPN1, TNKS, TP53
MF GO:0005488; binding GO:0020037; heme binding 4.657E-12 9.942E-10 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, MPO, NOX4, PTGS1, SRC
BP Unclassified; GO:0032844; regulation of homeostatic process 1.202E-11 2.380E-09 ADORA2A, ADRA2A, AURKB, BCL2, CA2, CA7, DRD3, HIF1A, HTR2C, KDR, MAPK1, MAPK14, NEK2, NPC1, NPSR1, PARP1, PLA2G1B, SRC, TNKS, TNKS2, TRPV1
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 1.953E-11 3.698E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
MF GO:0005488; binding GO:0005506; iron ion binding 8.009E-11 1.342E-08 ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, XDH
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 8.563E-11 1.408E-08 CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
BP GO:0008152; metabolic process GO:0018105; peptidyl-serine phosphorylation 1.179E-10 1.847E-08 AKT1, AURKB, BCL2, CAMK2B, CDK1, DYRK1A, GSK3B, MAPK1, MAPK14, NEK6, PKN1, SRC, TNKS
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 1.399E-10 2.116E-08 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2D6, CYP3A4
BP GO:0008152; metabolic process GO:0018107; peptidyl-threonine phosphorylation 1.439E-10 2.161E-08 AKT1, BCL2, CAMK2B, CDK1, CSNK2A1, DYRK1A, GSK3B, MAPK1, PKN1, TNKS
BP Unclassified; GO:0032846; positive regulation of homeostatic process 5.389E-10 6.862E-08 ADORA2A, AURKB, CA2, CA7, DRD3, HIF1A, MAPK1, MAPK14, NEK2, NPC1, NPSR1, PLA2G1B, TNKS, TNKS2
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 2.148E-09 2.339E-07 CYP1A2, CYP2C8, CYP2C9, CYP3A4
MF GO:0005488; binding GO:0005524; ATP binding 4.074E-09 4.306E-07 ABCB1, ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, CAMK2B, CDK1, CSNK2A1, DAPK1, DYRK1A, FLT3, GSK3B, IGF1R, KDR, MAPK1, MAPK14, MET, NEK2, NEK6, NUAK1, PIM1, PKM, PKN1, PTK2, PYGL, RECQL, SRC, TP53, TRPV1, VCP
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 4.742E-09 4.941E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.093E-08 1.068E-06 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 1.093E-08 1.068E-06 CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4
BP Unclassified; GO:2000021; regulation of ion homeostasis 2.169E-08 1.976E-06 ADORA2A, BCL2, CA2, CA7, DRD3, HTR2C, KDR, NPSR1, PARP1, PLA2G1B, SRC, TRPV1
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 4.188E-08 3.633E-06 AKT1, BCL2, HIF1A, LMNA, OPRD1, PPARD, SRC, TERT, TP53
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 6.081E-08 4.997E-06 ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B, TLR2
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 6.681E-08 5.449E-06 ABCC1, ADRA2A, CA2, CA4, CA9, HPGD, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3, TSHR
CC GO:0044425; membrane part GO:0005887; integral component of plasma membrane 7.836E-08 6.253E-06 ABCC1, ADORA2A, ADRA2A, ADRA2B, ADRA2C, ALK, APP, AXL, BACE1, DRD3, DRD4, FLT3, GLRA1, GLRA2, HTR2C, IGF1R, KDR, MET, MMP14, NPC1, NPSR1, OPRD1, SLC22A6, SLC22A8, SLCO1B1, SLCO1B3, TLR2, TRPV1, TSHR
BP GO:0065007; biological regulation GO:1904355; positive regulation of telomere capping 8.309E-08 6.580E-06 AURKB, MAPK1, NEK2, TNKS, TNKS2
MF GO:0003824; catalytic activity GO:0004674; protein serine/threonine kinase activity 9.329E-08 7.307E-06 AKT1, ALK, AURKB, CAMK2B, CDK1, CSNK2A1, DAPK1, DYRK1A, GSK3B, MAPK1, MAPK14, NEK2, NEK6, NUAK1, PIM1, PKN1
MF GO:0005488; binding GO:0051379; epinephrine binding 1.472E-07 1.101E-05 ADRA2A, ADRA2B, ADRA2C, DRD4
MF Unclassified; GO:0004872; receptor activity 1.837E-07 1.356E-05 ADORA2A, ADRA2A, ADRA2B, ADRA2C, AHR, ALK, AR, AXL, CXCR1, DRD3, DRD4, ESRRA, FLT3, GLRA1, GLRA2, HPGD, HTR2C, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, OPRD1, PPARA, PPARD, PPARG, TLR2, TRPV1, TSHR
MF GO:0060089; molecular transducer activity GO:0004938; alpha2-adrenergic receptor activity 3.192E-07 2.264E-05 ADRA2A, ADRA2B, ADRA2C
MF GO:0005488; binding GO:0046982; protein heterodimerization activity 3.264E-07 2.308E-05 ADORA2A, ADRA2A, ADRA2C, AHR, AXL, BCL2, HIF1A, MCL1, NFKB1, PIK3R1, PPARD, PPARG, SAE1, TLR2, TP53, TYR
BP GO:0051179; localization GO:0042307; positive regulation of protein import into nucleus 3.824E-07 2.669E-05 APP, CDK1, HDAC3, MAPK1, MAPK14, PARP1, PIK3R1, TLR2
BP GO:0065007; biological regulation GO:0000187; activation of MAPK activity 6.482E-07 4.226E-05 ADRA2B, ALK, CDK1, DRD4, MAPK1, MAPK14, PKN1, PLA2G1B, PTPN1
BP Unclassified; GO:0044236; multicellular organism metabolic process 6.999E-07 4.536E-05 HIF1A, MMP13, MMP14, MMP2, MMP3, MMP9, PLA2G1B, TRPV1
BP GO:0009987; cellular process GO:0030168; platelet activation 9.292E-07 5.916E-05 ADRA2A, ADRA2B, ADRA2C, AKT1, AXL, MAPK1, PIK3R1, SRC
MF GO:0140110; transcription regulator activity GO:0004879; nuclear receptor activity 1.044E-06 6.529E-05 AHR, AR, ESRRA, PPARA, PPARD, PPARG
MF GO:0005488; binding GO:0051721; protein phosphatase 2A binding 1.242E-06 7.682E-05 AKT1, BCL2, MAPT, PTPN1, TP53
BP GO:0065007; biological regulation GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway 1.270E-06 7.748E-05 ADRA2A, ADRA2B, ADRA2C
BP GO:0009987; cellular process GO:0032811; negative regulation of epinephrine secretion 1.270E-06 7.748E-05 ADRA2A, ADRA2B, ADRA2C
BP GO:0050896; response to stimulus GO:0045471; response to ethanol 1.392E-06 8.396E-05 CA3, CDK1, DRD3, GLRA1, GLRA2, HPGD, POLB, TP53
CC GO:0044464; cell part GO:0005829; cytosol 1.521E-06 9.050E-05 AHR, AKR1B1, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, BCL2, CA1, CA2, CA3, CA7, CAMK2B, CDK1, CSNK2A1, EP300, FABP2, FABP3, FABP4, FABP5, FLT3, GLO1, GSK3B, HDAC3, HIF1A, HPGD, HSD17B1, LMNA, MAPK1, MAPK14, MAPT, MCL1, MMP14, NEK2, NEK6, NFKB1, PGD, PIK3R1, PIM1, PKM, PKN1, PLA2G1B, PPARG, PTK2, PTPN1, PYGL, RAB9A, SRC, STAT6, TNKS, TNKS2, TP53, TRPV1, TYR, VCP, XDH
CC GO:0043226; organelle GO:0005654; nucleoplasm 1.588E-06 9.395E-05 AHR, AKR1B1, AKT1, ALOX5, AR, AURKB, BCL2, CAMK2B, CDK1, CSNK2A1, CTDSP1, DNMT1, DYRK1A, EP300, ESRRA, FABP5, GSK3B, HDAC3, HIF1A, HPGD, LMNA, MAPK1, MAPK14, MCL1, NEK2, NEK6, NFKB1, NUAK1, PARP1, PIM1, PKN1, POLB, PPARA, PPARD, PPARG, RECQL, SAE1, SRC, STAT6, TERT, TNKS, TP53, VCP
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 2.489E-06 1.397E-04 AHR, CSNK2A1, HIF1A, KDR, MAPT
BP GO:0008152; metabolic process GO:2000379; positive regulation of reactive oxygen species metabolic process 2.909E-06 1.616E-04 AKT1, MAPK14, MAPT, NOX4, TP53, TRPV1, XDH
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 3.159E-06 1.729E-04 CYP1A1, CYP2C8, CYP3A4
BP GO:0065007; biological regulation GO:0032148; activation of protein kinase B activity 3.401E-06 1.852E-04 ADRA2A, ADRA2B, ADRA2C, AKT1, SRC
BP GO:0065007; biological regulation GO:0032212; positive regulation of telomere maintenance via telomerase 3.401E-06 1.852E-04 AURKB, MAPK1, NEK2, TNKS, TNKS2
BP GO:0009987; cellular process GO:2000811; negative regulation of anoikis 3.667E-06 1.971E-04 BCL2, MCL1, PTK2, SRC
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 3.667E-06 1.971E-04 ALOX12, ALOX15, ALOX5, HPGD
BP GO:0009987; cellular process GO:2001243; negative regulation of intrinsic apoptotic signaling pathway 4.181E-06 2.215E-04 AKT1, BCL2, HIF1A, MCL1, MMP9, PTPN1, SRC
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 6.287E-06 3.176E-04 CYP1A1, CYP2C8, CYP3A4
BP Unclassified; GO:0032845; negative regulation of homeostatic process 7.017E-06 3.488E-04 ADRA2A, BCL2, HTR2C, PARP1, SRC, TNKS, TNKS2, TRPV1
BP GO:0009987; cellular process GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage 7.339E-06 3.624E-04 BCL2, EP300, MCL1, PIK3R1, POLB, TP53
MF GO:0003824; catalytic activity GO:0004712; protein serine/threonine/tyrosine kinase activity 9.950E-06 4.783E-04 AKT1, AURKB, DYRK1A, MAPK1, MAPK14
BP GO:0009987; cellular process GO:0048010; vascular endothelial growth factor receptor signaling pathway 1.024E-05 4.891E-04 AXL, KDR, MAPK14, PIK3R1, PTK2, SRC
MF GO:0005215; transporter activity GO:0008559; xenobiotic transmembrane transporting ATPase activity 1.095E-05 5.181E-04 ABCB1, ABCC1, ABCG2
BP Unclassified; GO:0044243; multicellular organismal catabolic process 1.110E-05 5.208E-04 MMP13, MMP14, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0050896; response to stimulus GO:0055093; response to hyperoxia 1.174E-05 5.451E-04 CYP1A1, POLB, PPARG, TP53
BP GO:0032502; developmental process GO:0031100; animal organ regeneration 1.401E-05 6.371E-04 AXL, CDK1, CSNK2A1, FLT3, PKM, PPARG
BP GO:0008283; cell proliferation GO:1904707; positive regulation of vascular smooth muscle cell proliferation 1.427E-05 6.475E-04 HPGD, MMP2, MMP9, TERT
BP GO:0051179; localization GO:0050482; arachidonic acid secretion 1.719E-05 7.637E-04 DRD3, DRD4, NMUR2, PLA2G1B
BP GO:0009987; cellular process GO:1903376; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 1.743E-05 7.678E-04 HIF1A, MCL1, PARP1
BP GO:0009987; cellular process GO:0010700; negative regulation of norepinephrine secretion 1.743E-05 7.678E-04 ADRA2A, ADRA2B, ADRA2C
MF GO:0005215; transporter activity GO:0015347; sodium-independent organic anion transmembrane transporter activity 2.051E-05 8.810E-04 SLC22A6, SLC22A8, SLCO1B1, SLCO1B3
BP GO:0008152; metabolic process GO:0019433; triglyceride catabolic process 2.429E-05 1.019E-03 FABP2, FABP3, FABP4, FABP5
BP GO:0032501; multicellular organismal process GO:0048143; astrocyte activation 2.601E-05 1.081E-03 ADORA2A, APP, MAPT
BP GO:0009987; cellular process GO:0031334; positive regulation of protein complex assembly 2.623E-05 1.088E-03 ALOX15, GSK3B, MAPT, MET, MMP3, PARP1, SRC, TP53, VCP
BP GO:0065007; biological regulation GO:0010952; positive regulation of peptidase activity 2.779E-05 1.148E-03 APP, DAPK1, MAPK14, MAPT, MMP14, PPARG, VCP, XDH
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 2.849E-05 1.169E-03 HIF1A, MMP13, MMP14, MMP2, MMP3, MMP9
BP GO:0009987; cellular process GO:0030522; intracellular receptor signaling pathway 2.895E-05 1.181E-03 AHR, AR, ESRRA, PIM1, PPARA, PPARD, PPARG, SRC
BP GO:0002376; immune system process GO:0043312; neutrophil degranulation 2.905E-05 1.181E-03 ALOX5, CXCR1, FABP5, GAA, MAPK1, MAPK14, MMP9, MPO, NFKB1, PKM, PYGL, TLR2, VCP
BP GO:0009987; cellular process GO:1901796; regulation of signal transduction by p53 class mediator 3.016E-05 1.221E-03 AKT1, AURKB, CSNK2A1, DYRK1A, EP300, MAPK14, NUAK1, TP53
MF GO:0005488; binding GO:0042803; protein homodimerization activity 3.311E-05 1.325E-03 ABCG2, ACHE, ADRA2A, ADRA2C, AKT1, BCL2, CAMK2B, FLT3, HPGD, MAPT, MCL1, NFKB1, PYGL, SLC22A6, TERT, TYR, XDH
BP GO:0065007; biological regulation GO:1904357; negative regulation of telomere maintenance via telomere lengthening 3.334E-05 1.330E-03 PARP1, SRC, TNKS, TNKS2
BP GO:0050896; response to stimulus GO:1904646; cellular response to amyloid-beta 3.334E-05 1.330E-03 APP, GSK3B, IGF1R, PARP1
BP GO:0050896; response to stimulus GO:0010332; response to gamma radiation 3.462E-05 1.371E-03 BCL2, NOX4, PARP1, POLB, TP53
MF GO:0005488; binding GO:0043621; protein self-association 3.462E-05 1.371E-03 ACHE, DYRK1A, FLT3, PPARG, TP53
CC GO:0016020; membrane GO:0045121; membrane raft 3.614E-05 1.425E-03 APP, BACE1, KDR, MAPK1, NPC1, OPRD1, SLC22A6, SRC, STAT6, TLR2
BP GO:0051179; localization GO:2001225; regulation of chloride transport 3.697E-05 1.443E-03 ABCB1, CA2, CA7
BP GO:0008152; metabolic process GO:0051974; negative regulation of telomerase activity 3.697E-05 1.443E-03 PPARG, SRC, TP53
BP GO:0051179; localization GO:0042908; xenobiotic transport 3.697E-05 1.443E-03 ABCB1, ABCC1, ABCG2
BP GO:0008152; metabolic process GO:0046320; regulation of fatty acid oxidation 3.869E-05 1.491E-03 AKT1, FABP3, PPARA, PPARG
BP GO:0051179; localization GO:0043252; sodium-independent organic anion transport 3.869E-05 1.491E-03 SLC22A6, SLC22A8, SLCO1B1, SLCO1B3
MF Unclassified; GO:0099600; transmembrane receptor activity 4.541E-05 1.708E-03 ADORA2A, ADRA2A, ADRA2B, ADRA2C, ALK, AXL, CXCR1, DRD3, DRD4, FLT3, HPGD, HTR2C, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, OPRD1, PPARG, TRPV1, TSHR
MF GO:0005488; binding GO:0019901; protein kinase binding 4.594E-05 1.725E-03 ADRA2A, AKT1, GSK3B, HIF1A, MAPK1, MAPK14, NEK6, PARP1, PIK3R1, PKN1, PTK2, PTPN1, SRC, TP53
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 4.706E-05 1.749E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 4.706E-05 1.749E-03 ALOX12, ALOX15
BP GO:0009987; cellular process GO:0045600; positive regulation of fat cell differentiation 5.332E-05 1.925E-03 AKT1, HTR2C, MAPK14, PPARD, PPARG
MF GO:0060089; molecular transducer activity GO:0003707; steroid hormone receptor activity 5.332E-05 1.925E-03 AR, ESRRA, PPARA, PPARD, PPARG
BP GO:0050896; response to stimulus GO:0031663; lipopolysaccharide-mediated signaling pathway 5.851E-05 2.079E-03 AKT1, MAPK1, MAPK14, TLR2
BP GO:0009987; cellular process GO:0071276; cellular response to cadmium ion 5.851E-05 2.079E-03 AKT1, CYP1A2, MAPK1, MMP9
BP GO:0048511; rhythmic process GO:0042752; regulation of circadian rhythm 5.963E-05 2.111E-03 ADORA2A, DRD3, DRD4, PPARA, PPARG, TP53
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 6.267E-05 2.194E-03 AKR1B1, AXL, CDK1, CYP1B1, STAT6
CC GO:0044464; cell part GO:0005739; mitochondrion 6.990E-05 2.393E-03 AKT1, BCL2, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, CYP2D6, GSK3B, HSD17B10, MAOA, MAPK1, MAPK14, MCL1, MMP2, MPO, NFKB1, NOX4, PARP1, PKM, SRC, TP53
CC GO:0044464; cell part GO:0034774; secretory granule lumen 7.759E-05 2.637E-03 ALOX5, APP, FABP5, MAPK1, MAPK14, MPO, NFKB1, PKM, PYGL, VCP
BP GO:0009987; cellular process GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 8.487E-05 2.843E-03 AKT1, BCL2, MCL1, TERT
BP GO:0008152; metabolic process GO:0030574; collagen catabolic process 8.512E-05 2.847E-03 MMP13, MMP14, MMP2, MMP3, MMP9
BP GO:0008152; metabolic process GO:0006703; estrogen biosynthetic process 8.678E-05 2.889E-03 CYP19A1, HSD17B1, HSD17B2
BP GO:0023052; signaling GO:0032230; positive regulation of synaptic transmission, GABAergic 8.678E-05 2.889E-03 ADORA2A, CA2, CA7
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 8.843E-05 2.935E-03 AXL, MET, NOX4, PIK3R1, PTK2, SRC, THPO
BP GO:0008152; metabolic process GO:0031331; positive regulation of cellular catabolic process 9.230E-05 3.040E-03 ADRA2A, AKT1, CDK1, DAPK1, GSK3B, HIF1A, KDR, PPARA, PTK2, PTPN1, VCP
BP GO:0065007; biological regulation GO:0051100; negative regulation of binding 9.996E-05 3.254E-03 AURKB, CYP2D6, GSK3B, MET, NEK2, PPARA, TNKS
BP GO:0008283; cell proliferation GO:0008285; negative regulation of cell proliferation 1.033E-04 3.348E-03 ADORA2A, APP, AR, BCL2, CYP1B1, FABP3, LMNA, NOX4, PKN1, PPARD, PPARG, TERT, TLR2, TP53, XDH
BP GO:0008152; metabolic process GO:0045913; positive regulation of carbohydrate metabolic process 1.057E-04 3.409E-03 AKT1, HIF1A, NFKB1, PPARA, SRC
BP GO:0040011; locomotion GO:0014911; positive regulation of smooth muscle cell migration 1.067E-04 3.426E-03 BCL2, NOX4, SRC, TERT
MF Unclassified; GO:0032403; protein complex binding 1.165E-04 3.724E-03 ACHE, ADRA2A, FLT3, IGF1R, KDR, MMP13, MMP14, MMP9, PIK3R1, PKM, PPARA, PTPN1, SRC, TLR2, TSHR, VCP
BP GO:0065007; biological regulation GO:0042593; glucose homeostasis 1.172E-04 3.737E-03 ADRA2A, AKT1, HIF1A, NOX4, PIK3R1, PPARG, PYGL
MF GO:0005488; binding GO:0002039; p53 binding 1.213E-04 3.846E-03 EP300, GSK3B, HIF1A, NUAK1, TP53
BP GO:0008152; metabolic process GO:0010507; negative regulation of autophagy 1.298E-04 4.073E-03 AKT1, BCL2, MCL1, MET, NPC1
BP GO:0065007; biological regulation GO:0051101; regulation of DNA binding 1.316E-04 4.123E-03 MMP9, NEK2, PARP1, PPARA, PPARG, TNKS
BP GO:0051179; localization GO:0070198; protein localization to chromosome, telomeric region 1.367E-04 4.252E-03 TERT, TNKS, TNKS2
BP GO:0032501; multicellular organismal process GO:0014005; microglia development 1.405E-04 4.310E-03 APP, TLR2
BP GO:0008152; metabolic process GO:0009822; alkaloid catabolic process 1.405E-04 4.310E-03 CYP2D6, CYP3A4
BP GO:0051179; localization GO:0099039; sphingolipid translocation 1.405E-04 4.310E-03 ABCB1, ABCC1
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.405E-04 4.310E-03 CA2, CA7
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.405E-04 4.310E-03 CYP1A1, CYP3A4
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.405E-04 4.310E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.405E-04 4.310E-03 ALOX12, ALOX15
BP GO:0050896; response to stimulus GO:0050728; negative regulation of inflammatory response 1.449E-04 4.438E-03 ADORA2A, CYP19A1, NFKB1, PPARA, PPARD, PPARG
BP GO:0050896; response to stimulus GO:0043627; response to estrogen 1.481E-04 4.517E-03 CA2, EP300, MAPK1, MMP14, PPARG
MF GO:0005488; binding GO:0001085; RNA polymerase II transcription factor binding 1.520E-04 4.621E-03 AHR, AR, EP300, GSK3B, PPARA, TP53
BP GO:0008152; metabolic process GO:0016579; protein deubiquitination 1.570E-04 4.762E-03 AR, CDK1, EP300, HIF1A, POLB, TNKS, TNKS2, TP53, VCP
BP GO:0009987; cellular process GO:0032459; regulation of protein oligomerization 1.620E-04 4.884E-03 MMP3, OPRD1, SRC, TP53
BP GO:0051179; localization GO:0051924; regulation of calcium ion transport 1.735E-04 5.190E-03 ADORA2A, ADRA2A, BCL2, CAMK2B, DRD4, NPSR1, OPRD1, PLA2G1B
CC GO:0044464; cell part GO:0032589; neuron projection membrane 1.786E-04 5.319E-03 ADORA2A, MAPT, OPRD1, TRPV1
BP GO:0009987; cellular process GO:1901216; positive regulation of neuron death 1.906E-04 5.618E-03 GSK3B, MAPT, MCL1, PARP1, TP53
BP GO:0009987; cellular process GO:0071356; cellular response to tumor necrosis factor 1.914E-04 5.624E-03 AKT1, FABP4, MAPK1, MAPK14, NFKB1, TRPV1
CC GO:0016020; membrane GO:0005789; endoplasmic reticulum membrane 1.987E-04 5.824E-03 BCL2, CAMK2B, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, HSD17B2, NOX4, PTGS1, RAB9A, VCP
BP GO:0002376; immune system process GO:0001774; microglial cell activation 2.022E-04 5.850E-03 MAPT, TLR2, TRPV1
BP GO:0008152; metabolic process GO:0046209; nitric oxide metabolic process 2.022E-04 5.850E-03 AKT1, CYP1B1, TLR2
BP GO:0050896; response to stimulus GO:0033189; response to vitamin A 2.022E-04 5.850E-03 CYP1A1, PPARD, PPARG
BP GO:0009987; cellular process GO:1900034; regulation of cellular response to heat 2.026E-04 5.850E-03 CAMK2B, EP300, GSK3B, MAPK1, MAPT
BP GO:0007610; behavior GO:0008344; adult locomotory behavior 2.026E-04 5.850E-03 APP, DRD4, GLRA1, NPC1, OPRD1
MF GO:0003824; catalytic activity GO:0008392; arachidonic acid epoxygenase activity 2.022E-04 5.850E-03 CYP2C19, CYP2C8, CYP2C9
MF GO:0003824; catalytic activity GO:0035173; histone kinase activity 2.022E-04 5.850E-03 AURKB, CDK1, PKN1
BP GO:0009987; cellular process GO:0022617; extracellular matrix disassembly 2.151E-04 6.144E-03 MMP13, MMP14, MMP2, MMP3, MMP9
BP GO:0051179; localization GO:0046326; positive regulation of glucose import 2.153E-04 6.144E-03 AKT1, MAPK14, PIK3R1, TERT
BP GO:0009987; cellular process GO:0050714; positive regulation of protein secretion 2.263E-04 6.417E-03 ACHE, ADORA2A, HIF1A, MAPK14, PLA2G1B, PPARD, SRC, TLR2
BP GO:0050896; response to stimulus GO:0070542; response to fatty acid 2.281E-04 6.451E-03 AKT1, FABP3, PPARG, SRC, TLR2
BP GO:0032501; multicellular organismal process GO:0043536; positive regulation of blood vessel endothelial cell migration 2.356E-04 6.636E-03 AKT1, HIF1A, KDR, MAPK14
BP GO:0008152; metabolic process GO:0051000; positive regulation of nitric-oxide synthase activity 2.414E-04 6.757E-03 AKT1, HIF1A, TERT
BP GO:0050896; response to stimulus GO:0031000; response to caffeine 2.414E-04 6.757E-03 ADORA2A, PPARG, TP53
BP GO:0050896; response to stimulus GO:1901655; cellular response to ketone 2.418E-04 6.759E-03 AKR1B1, AKT1, AR, PPARG, SRC
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 2.572E-04 7.106E-03 AKT1, LMNA, MMP9, TP53
BP GO:0065007; biological regulation GO:0032431; activation of phospholipase A2 activity 2.798E-04 7.597E-03 NMUR2, PLA2G1B
BP GO:0008152; metabolic process GO:0070213; protein auto-ADP-ribosylation 2.798E-04 7.597E-03 TNKS, TNKS2
BP GO:0032501; multicellular organismal process GO:0032640; tumor necrosis factor production 2.798E-04 7.597E-03 APP, TLR2
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 2.798E-04 7.597E-03 CYP1A1, CYP1A2
BP Unclassified; GO:0042993; positive regulation of transcription factor import into nucleus 2.802E-04 7.597E-03 APP, HDAC3, PIK3R1, TLR2
MF GO:0005488; binding GO:0005497; androgen binding 2.798E-04 7.597E-03 ALDH1A1, AR
BP GO:0009987; cellular process GO:0043401; steroid hormone mediated signaling pathway 2.824E-04 7.638E-03 AR, ESRRA, PPARA, PPARD, PPARG, SRC
BP GO:0065007; biological regulation GO:0032092; positive regulation of protein binding 3.029E-04 8.122E-03 APP, EP300, GSK3B, MMP9, TERT
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 3.046E-04 8.129E-03 IGF1R, KDR, PTK2, SRC
BP Unclassified; GO:1905953; negative regulation of lipid localization 3.046E-04 8.129E-03 AKT1, NFKB1, PPARA, PPARG
MF GO:0005488; binding GO:0005496; steroid binding 3.198E-04 8.492E-03 AR, CYP3A4, ESRRA, HSD17B1, NPC1
BP GO:0009987; cellular process GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway 3.339E-04 8.835E-03 ADRA2A, ADRA2B, ADRA2C
MF GO:0005488; binding GO:0001223; transcription coactivator binding 3.339E-04 8.835E-03 AHR, PPARA, TERT
BP GO:0008152; metabolic process GO:1900372; negative regulation of purine nucleotide biosynthetic process 3.580E-04 9.404E-03 ADRA2A, DRD3, DRD4, PARP1
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 1.442E-21 3.926E-18 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0051179; localization GO:0015701; bicarbonate transport 6.847E-15 3.222E-12 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 3.710E-14 1.496E-11 CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 8.824E-21 1.721E-18 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 6.311E-12 6.153E-10 CAMK2B; SRC; MMP2; PIK3R1; MAPK14; HIF1A; MMP9; PTK2; IGF1R; KDR; AKT1; MAPK1; TP53; MET; TLR2
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 1.800E-11 8.773E-10 GSK3B; FLT3; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; NFKB1; PTK2; IGF1R; AR; BCL2; AKT1; EP300; MAPK1; PPARG; MET; TP53; PPARD
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 1.135E-11 7.376E-10 CYP2C9; APP; CYP2C8; CYP2D6; MAOA; ALOX5; ALOX15; HTR2C; MAPK1; ALOX12; CYP2C19; PTGS1
hsa05215 Prostate cancer_Homo sapiens_hsa05215 3.913E-10 1.526E-08 GSK3B; AR; BCL2; AKT1; EP300; MAPK1; PIK3R1; TP53; NFKB1; IGF1R
hsa05161 Hepatitis B_Homo sapiens_hsa05161 3.782E-09 1.054E-07 SRC; BCL2; AKT1; EP300; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1; TLR2
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 7.734E-09 1.885E-07 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS1
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 6.777E-10 2.202E-08 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 1.451E-08 3.144E-07 PKM; FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 6.614E-08 9.212E-07 GSK3B; PIK3R1; PTK2; NFKB1; IGF1R; KDR; BCL2; AKT1; MAPK1; PKN1; TP53; MET; TLR2; MCL1
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 2.866E-08 5.589E-07 CAMK2B; BCL2; AKT1; EP300; MAPK1; PIK3R1; HIF1A; NFKB1; IGF1R
hsa04080 Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 4.234E-08 6.351E-07 OPRD1; HTR2C; TRPV1; ADRA2C; ADRA2B; ADRA2A; TSHR; GLRA1; GLRA2; ADORA2A; NMUR2; DRD3; DRD4
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 3.367E-08 5.969E-07 HPGD; FLT3; MMP3; PPARG; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 3.862E-08 6.276E-07 HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 9.552E-08 1.085E-06 DNMT1; ABCC1; ABCB1; MMP9; NFKB1; PIM1; BCL2; CYP1B1; EP300; MAPK1; TP53; MET; MCL1
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 9.389E-08 1.085E-06 GSK3B; HDAC3; SRC; AKT1; EP300; MAPK1; PIK3R1; TP53; HIF1A
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 1.484E-07 1.378E-06 DNMT1; PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; CYP19A1; HSD17B10; PTGS1; HSD17B1; ALOX5; HSD17B2; XDH; GAA; PGD; TYR; CYP2C9; CYP2C8; PKM; CYP1A2; ALDH1A1; CYP1A1; ALPL
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 1.086E-07 1.085E-06 CAMK2B; GSK3B; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; TP53; NFKB1
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 9.835E-08 1.085E-06 FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 1.086E-07 1.085E-06 OPRD1; ABCC1; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; TP53; NFKB1
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 3.722E-07 2.817E-06 MMP2; PIM1; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1
hsa04210 Apoptosis_Homo sapiens_hsa04210 4.066E-07 2.937E-06 PARP1; LMNA; BCL2; AKT1; MAPK1; PIK3R1; TP53; NFKB1; MCL1
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 1.588E-07 1.407E-06 SRC; KDR; AKT1; MAPK1; PIK3R1; MAPK14; PTK2
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 1.015E-06 5.998E-06 GSK3B; CSNK2A1; BCL2; CDK1; AKT1; EP300; PIK3R1; MAPK14; TP53; NFKB1
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 1.112E-07 1.085E-06 HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 7.176E-07 4.514E-06 MMP14; MMP3; AKT1; MAPK1; PIK3R1; MAPK14; MMP9; NFKB1
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 1.161E-06 6.657E-06 POLB; PKM; HDAC3; SRC; CDK1; EP300; MAPK1; PIK3R1; TP53; NFKB1
hsa04510 Focal adhesion_Homo sapiens_hsa04510 1.015E-06 5.998E-06 GSK3B; SRC; KDR; BCL2; AKT1; MAPK1; PIK3R1; MET; PTK2; IGF1R
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 5.045E-07 3.392E-06 GSK3B; SRC; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 3.757E-07 2.817E-06 CYP2C9; CYP2C8; MAOA; CYP2D6; CYP1A2; CYP3A4; CYP2C19
hsa03320 PPAR signaling pathway_Homo sapiens_hsa03320 3.757E-07 2.817E-06 FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 1.226E-06 6.674E-06 ALOX5; BCL2; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2
hsa04520 Adherens junction_Homo sapiens_hsa04520 6.095E-07 3.962E-06 PTPN1; CSNK2A1; SRC; EP300; MAPK1; MET; IGF1R
hsa04976 Bile secretion_Homo sapiens_hsa04976 4.580E-07 3.189E-06 SLCO1B1; ABCB1; CA2; SLCO1B3; SLC22A8; CYP3A4; ABCG2
hsa05219 Bladder cancer_Homo sapiens_hsa05219 2.868E-07 2.431E-06 DAPK1; SRC; MMP2; MAPK1; MMP9; TP53
hsa05160 Hepatitis C_Homo sapiens_hsa05160 3.020E-06 1.511E-05 GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; PPARA; TP53; NFKB1
hsa05152 Tuberculosis_Homo sapiens_hsa05152 3.023E-06 1.511E-05 CAMK2B; SRC; BCL2; AKT1; EP300; MAPK1; MAPK14; NFKB1; TLR2
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 1.842E-06 9.710E-06 CAMK2B; GSK3B; SRC; AKT1; MAPK1; PIK3R1; PTK2
hsa05162 Measles_Homo sapiens_hsa05162 3.568E-06 1.697E-05 GSK3B; CSNK2A1; AKT1; RAB9A; PIK3R1; TP53; NFKB1; TLR2
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 4.106E-06 1.906E-05 CAMK2B; SRC; HTR2C; ALOX12; TRPV1; PIK3R1; MAPK14
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 7.498E-06 3.179E-05 CAMK2B; ADORA2A; AKT1; EP300; MAPK1; PIK3R1; PPARA; NFKB1; TSHR
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 1.232E-06 6.674E-06 CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 1.200E-05 4.590E-05 ADORA2A; SRC; KDR; AKT1; MAPK1; PIK3R1; MAPK14; MET; IGF1R
hsa04630 Jak-STAT signaling pathway_Homo sapiens_hsa04630 1.079E-05 4.210E-05 THPO; PIM1; BCL2; AKT1; EP300; STAT6; PIK3R1; MCL1
hsa04931 Insulin resistance_Homo sapiens_hsa04931 8.323E-06 3.381E-05 PTPN1; GSK3B; AKT1; PIK3R1; PYGL; PPARA; NFKB1
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 3.498E-06 1.697E-05 GSK3B; BCL2; AKT1; MAPK1; PIK3R1; TP53
hsa05214 Glioma_Homo sapiens_hsa05214 4.623E-06 2.049E-05 CAMK2B; AKT1; MAPK1; PIK3R1; TP53; IGF1R
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 2.501E-05 9.032E-05 CAMK2B; GSK3B; MAOA; AKT1; MAPK14; DRD3; DRD4
hsa05218 Melanoma_Homo sapiens_hsa05218 7.760E-06 3.219E-05 AKT1; MAPK1; PIK3R1; TP53; MET; IGF1R
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 3.641E-05 1.224E-04 GSK3B; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 5.058E-06 2.192E-05 AKT1; EP300; MAPK1; PIK3R1; MET; HIF1A
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 4.623E-06 2.049E-05 CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 3.240E-05 1.149E-04 CAMK2B; MMP14; SRC; MMP2; MAPK1; MAPK14
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 2.348E-05 8.805E-05 BCL2; AKT1; PIK3R1; TP53; NFKB1; PTK2
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 4.926E-05 1.601E-04 CDK1; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 9.123E-06 3.631E-05 CYP2C9; CYP2D6; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 3.894E-05 1.287E-04 AKT1; PPARG; PIK3R1; TP53; NFKB1; IGF1R
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 5.215E-05 1.667E-04 SRC; MMP2; AKT1; MAPK1; PIK3R1; MMP9
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 5.835E-05 1.835E-04 CAMK2B; PKM; AKT1; EP300; PYGL; PPARA
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 7.644E-05 2.293E-04 AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 1.413E-04 3.790E-04 PLA2G1B; KDR; AKT1; MAPK1; PIK3R1; MET; NFKB1; IGF1R
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 6.873E-05 2.094E-04 AKT1; MAPK1; PIK3R1; MAPK14; NFKB1; TLR2
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 9.875E-05 2.832E-04 CAMK2B; ACHE; BCL2; AKT1; MAPK1; PIK3R1
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 6.873E-05 2.094E-04 GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; NFKB1
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 1.285E-04 3.530E-04 OPRD1; AKT1; MAPK1; PIK3R1; ADRA2C; ADRA2B; ADRA2A
hsa05164 Influenza A_Homo sapiens_hsa05164 1.717E-04 4.464E-04 GSK3B; AKT1; EP300; MAPK1; PIK3R1; MAPK14; NFKB1
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 3.366E-04 8.308E-04 POLB; GSK3B; TERT; AKT1; EP300; PIK3R1; TP53; NFKB1
hsa04611 Platelet activation_Homo sapiens_hsa04611 1.661E-04 4.377E-04 SRC; AKT1; MAPK1; PIK3R1; MAPK14; PTGS1
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 2.549E-04 6.540E-04 AKT1; MAPK1; PPARG; PIK3R1; MAPK14; NFKB1
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 2.655E-04 6.723E-04 AKT1; EP300; MAPK1; PIK3R1; MAPK14; IGF1R
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 3.773E-04 9.084E-04 GSK3B; AKT1; MAPK1; PIK3R1; MAPK14; IGF1R
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 3.366E-04 8.308E-04 PTPN1; GSK3B; AKT1; MAPK1; PIK3R1; PYGL
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 3.773E-04 9.084E-04 CAMK2B; GSK3B; CSNK2A1; EP300; TP53; PPARD
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 4.703E-04 1.105E-03 CAMK2B; BCL2; AKT1; MAPK1; PIK3R1; MAPK14
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 9.146E-04 2.051E-03 BACE1; APP; GSK3B; MAPK1; MAPT; HSD17B10
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 2.439E-05 8.973E-05 GSK3B; AKT1; MAPK1; PIK3R1; TP53
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 3.509E-05 1.201E-04 FABP4; AKT1; PIK3R1; TSHR; PTGS1
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 3.509E-05 1.201E-04 ALK; AKT1; MAPK1; PIK3R1; TP53
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 1.261E-04 3.512E-04 AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 1.501E-03 3.147E-03 CSNK2A1; CDK1; EP300; TP53; NFKB1; TLR2
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 1.261E-04 3.512E-04 GSK3B; AKT1; MAPK1; PIK3R1; NFKB1
hsa04916 Melanogenesis_Homo sapiens_hsa04916 5.477E-04 1.271E-03 CAMK2B; GSK3B; EP300; MAPK1; TYR
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 3.402E-03 6.770E-03 GSK3B; AKT1; PIK3R1; PPARA; NFKB1
hsa04114 Oocyte meiosis_Homo sapiens_hsa04114 1.392E-03 2.983E-03 CAMK2B; AR; CDK1; MAPK1; IGF1R
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 7.235E-03 1.331E-02 AKT1; MAPK1; MAPT; MAPK14; TP53; NFKB1
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 7.785E-05 2.300E-04 AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04144 Endocytosis_Homo sapiens_hsa04144 2.960E-02 4.655E-02 CXCR1; SRC; KDR; MET; IGF1R
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 1.157E-03 2.508E-03 MMP2; PIK3R1; MAPK14; MMP9; PTK2
hsa04060 Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 3.221E-02 4.945E-02 CXCR1; THPO; FLT3; KDR; MET
hsa05034 Alcoholism_Homo sapiens_hsa05034 3.173E-02 4.911E-02 HDAC3; ADORA2A; MAOA; MAPK1
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 2.130E-02 3.491E-02 CAMK2B; SRC; MAPK1; PIK3R1
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 1.571E-02 2.641E-02 CXCR1; AKT1; MAPK1; PIK3R1
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 8.985E-05 2.615E-04 CXCR1; SRC; MAPK14; MET; NFKB1
hsa04110 Cell cycle_Homo sapiens_hsa04110 9.489E-03 1.682E-02 GSK3B; CDK1; EP300; TP53
hsa04152 AMPK signaling pathway_Homo sapiens_hsa04152 9.489E-03 1.682E-02 AKT1; PPARG; PIK3R1; IGF1R
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 4.641E-03 8.872E-03 AKT1; MAPK1; PIK3R1; HIF1A
hsa04360 Axon guidance_Homo sapiens_hsa04360 1.030E-02 1.777E-02 GSK3B; MAPK1; MET; PTK2
hsa05146 Amoebiasis_Homo sapiens_hsa05146 4.479E-03 8.648E-03 PIK3R1; NFKB1; PTK2; TLR2
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 2.417E-02 3.896E-02 AKT1; MAPK1; PIK3R1
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 3.456E-03 6.808E-03 CSNK2A1; PARP1; BCL2; NFKB1
hsa04540 Gap junction_Homo sapiens_hsa04540 2.832E-03 5.752E-03 SRC; CDK1; HTR2C; MAPK1
hsa05132 Salmonella infection_Homo sapiens_hsa05132 2.605E-03 5.347E-03 MAPK1; PKN1; MAPK14; NFKB1
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 1.823E-03 3.781E-03 SRC; PIK3R1; MET; PTK2
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 1.095E-03 2.400E-03 AKT1; MAPK1; PIK3R1; MAPK14
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 1.427E-03 3.024E-03 MAPK1; MAPK14; NFKB1; TLR2
hsa05133 Pertussis_Homo sapiens_hsa05133 1.371E-02 2.324E-02 MAPK1; MAPK14; NFKB1
hsa04920 Adipocytokine signaling pathway_Homo sapiens_hsa04920 1.138E-02 1.947E-02 AKT1; PPARA; NFKB1
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 6.832E-04 1.567E-03 AKT1; MAPK1; PIK3R1; HIF1A
hsa04720 Long-term potentiation_Homo sapiens_hsa04720 9.697E-03 1.704E-02 CAMK2B; EP300; MAPK1
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 8.915E-03 1.625E-02 AKT1; PIK3R1; IGF1R
hsa05131 Shigellosis_Homo sapiens_hsa05131 9.245E-04 2.051E-03 SRC; MAPK1; MAPK14; NFKB1
hsa05321 Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 9.301E-03 1.679E-02 STAT6; NFKB1; TLR2
hsa04621 NOD-like receptor signaling pathway_Homo sapiens_hsa04621 6.475E-03 1.202E-02 MAPK1; MAPK14; NFKB1
hsa05134 Legionellosis_Homo sapiens_hsa05134 5.861E-03 1.099E-02 VCP; NFKB1; TLR2
hsa05014 Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 4.743E-03 8.980E-03 BCL2; MAPK14; TP53
hsa04930 Type II diabetes mellitus_Homo sapiens_hsa04930 3.997E-03 7.794E-03 PKM; MAPK1; PIK3R1
hsa04960 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 2.770E-02 4.428E-02 MAPK1; PIK3R1
hsa04975 Fat digestion and absorption_Homo sapiens_hsa04975 3.040E-02 4.742E-02 FABP2; PLA2G1B
hsa02010 ABC transporters_Homo sapiens_hsa02010 3.120E-03 6.272E-03 ABCC1; ABCB1; ABCG2
hsa00620 Pyruvate metabolism_Homo sapiens_hsa00620 2.904E-02 4.603E-02 PKM; GLO1
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 1.419E-04 3.790E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.691E-02 2.818E-02 GAA; AKR1B1
hsa00350 Tyrosine metabolism_Homo sapiens_hsa00350 2.263E-02 3.677E-02 MAOA; TYR
hsa03410 Base excision repair_Homo sapiens_hsa03410 2.026E-02 3.347E-02 POLB; PARP1
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 9.257E-04 2.051E-03 MAPK1; PPARG; TP53
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 1.013E-02 1.764E-02 CA2; CA4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 4.332E-04 1.030E-03 CYP1A2; XDH
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
N00-N99: Diseases of the genitourinary system Prostate hyperplasia N40 AR
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 ALOX5
NA: NA Rheumatold arthritis NA PTGS1; MAPK14
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 CAMK2B; AKR1B1; PLA2G1B; ESRRA; OPRD1; MMP3; ALOX5; MAPK14; TYR
G00-G99: Diseases of the nervous system G00-G99 Acute migraine G43 OPRD1; TRPV1
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3
C00-D49: Neoplasms Acute myeloid leukemia C92.0 TERT; FLT3; FLT3; DNMT1; DNMT1; AURKB; TP53; TP53
J00-J99: Diseases of the respiratory system Acute lung injury J80 MAPK14
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Acute or chronic pain R52, G89 TRPV1
NA: NA Acute nonspecific diarrhea NA OPRD1
G00-G99: Diseases of the nervous system G00-G99 Ataxia telangiectasia G11.3 PARP1
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
C00-D49: Neoplasms Soft tissue sarcoma C00-D49 DNMT1
C00-D49: Neoplasms Solid tumours C00-D48 AKT1; MET; PKM; ABCB1; FLT3; CA9; MMP2; MMP14; SRC; IGF1R; PTK2; AURKB; HIF1A; MAPK1; MMP9; TLR2; TP53; KDR; KDR; KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Contusion S36.220S ADRA2C
C00-D49: Neoplasms Multiple myeloma C90 AHR; VCP; TERT; SRC; IGF1R; BCL2
M00-M99: Diseases of the musculoskeletal system and connective tissue Muscle atrophy M62.5 AR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Musculoskeletal pain R52, G89 TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Sexual dysfunction F52 ADRA2A
NA: NA Sleep initiation and maintenance disorders NA HTR2C
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CAMK2B; MAOA; OPRD1; ACHE; HTR2C; CYP3A4
A00-B99: Certain infectious and parasitic diseases Anthelmintic B89 ALPL
NA: NA Miosis during ocular surgery NA PTGS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA; HTR2C
C00-D49: Neoplasms Colorectal cancer C18-C21 FLT3; PTGS1; IGF1R; MMP9; TP53; KDR
C00-D49: Neoplasms Colon cancer C50 ALPL; FLT3
NA: NA Dyslipidemia NA PPARD
N00-N99: Diseases of the genitourinary system Dysmenorrhea N94.4-N94.6 PTGS1
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT; PPARD
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases Testosterone deficiency E29.1 AR
C00-D49: Neoplasms Thyroid cancer C73 TSHR; KDR
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
G00-G99: Diseases of the nervous system G00-G99 Amyotrophic lateral sclerosis G12.2 BCL2
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE
G00-G99: Diseases of the nervous system G00-G99 Permanent and transient stroke G45.9, I61-I63 PARP1
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE; ADRA2C
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
C00-D49: Neoplasms Melanoma C43 TERT; PARP1; TLR2; TYR; KDR; KDR
Z00-Z99: Factors influencing health status and contact with health services Contraception Z30 AR
H00-H59: Diseases of the eye and adnexa Corneal ulcers H16.0 MMP3
I00-I99: Diseases of the circulatory system Coronary artery disease I20-I25 MAPK14; MAPK14
I00-I99: Diseases of the circulatory system Coronary disorder diagnosis I20-I25 ADORA2A
I00-I99: Diseases of the circulatory system Heart failure I50 AR; XDH; ADRA2C
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 PLA2G1B; ESRRA; ADORA2A; ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 PLA2G1B; ALOX5
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; MAPT; ACHE; ACHE; ACHE; GSK3B; ADRA2C; PPARG; PPARG; APP
L00-L99: Diseases of the skin and subcutaneous tissue Alopecia L65.9 AR
S00-T88: Injury, poisoning and certain other consequences of external causes Postoperative inflammation T81 PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 GAA
C00-D49: Neoplasms Overactive bladder disorder C67, N32.81 OPRD1; TRPV1; TRPV1
C00-D49: Neoplasms AML NA FLT3; KDR
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA; OPRD1; ADRA2C; ADRA2B; HTR2C
K00-K95: Diseases of the digestive system Alcoholic hepatitis K70.1 AR
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
H00-H59: Diseases of the eye and adnexa Age related macular degeneration H35.3 APP
C00-D49: Neoplasms Aggressive non-hodgkin's lymphoma C81, C81-C86, C82-C85, C91-C95 HTR2C
A00-B99: Certain infectious and parasitic diseases Postherpetic neuralgia B02.2, G44.847, G53.0 TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Premature ejaculation F52.4 OPRD1
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
C00-D49: Neoplasms Brain cancer C71, D33 TERT; SRC
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1; PPARG
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Emesis R11 DRD3
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
NA: NA Edema NA CA2
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA; TRPV1; PTGS1; ADORA2A; ADRA2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Attention deficit hyperactivity disorder F90 ADRA2A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cough R05 OPRD1; TRPV1
NA: NA Early satiation associated with functional dyspepsia NA ACHE
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA2; CA1
E00-E89: Endocrine, nutritional and metabolic diseases Dyslipidaemias E78 PPARD; PPARD
C00-D49: Neoplasms Glioblastoma multiforme C71 DNMT1; SRC
NA: NA Geographic retinal atrophy NA APP
I00-I99: Diseases of the circulatory system Cerebrovascular disorders I60-I69 PARP1
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA; TYR
E00-E89: Endocrine, nutritional and metabolic diseases Type 1 diabetes E10 PPARG; PPARD
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 ABCB1; CYP2C9
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 TLR2
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 TRPV1; ALOX5
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
C00-D49: Neoplasms Tumors C00-D48 TERT
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 PTPN1; PTPN1; NFKB1; PPARG; PPARG; PPARD
G00-G99: Diseases of the nervous system G00-G99 Migraine headaches G43 HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE; APP
C00-D49: Neoplasms Metastatic prostate cancer C61 AR
G00-G99: Diseases of the nervous system G00-G99 Migraine G43 CYP2D6
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B; ABCC1; ESRRA; ALOX5; MAPK14
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 PLA2G1B; ADORA2A
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; KDR
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA
G00-G99: Diseases of the nervous system G00-G99 Mild to moderate alzheimer disease G30 APP
C00-D49: Neoplasms Adrenocortical carcinoma C74.0 ABCB1
I00-I99: Diseases of the circulatory system Acute coronary syndrome I74 MAPK14
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1; PTPN1; GSK3B; HTR2C; PPARG
NA: NA Upper abdominal bloating NA ACHE
K00-K95: Diseases of the digestive system Ulcerative colitis K51 PTGS1; MMP9
N00-N99: Diseases of the genitourinary system Urinary incontinence N39.3, N39.4, R32 OPRD1; TRPV1
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 AR; KDR
C00-D49: Neoplasms Mesothelioma C45 PTK2
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 PPARD
C00-D49: Neoplasms Metastatic breast cancer C50 KDR
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
G00-G99: Diseases of the nervous system G00-G99 Multiple scierosis G35 MPO
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA; ADRA2C; HTR2C
K00-K95: Diseases of the digestive system Peptic ulcer K25-K27 ADRA2C
C00-D49: Neoplasms Bladder cancer C67 AR; CYP19A1
N00-N99: Diseases of the genitourinary system Bladder disease N30-N32 OPRD1
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
L00-L99: Diseases of the skin and subcutaneous tissue Melasma L81.1 TYR
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; TERT; TP53; KDR; KDR
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1
E00-E89: Endocrine, nutritional and metabolic diseases Cystic fibrosis E84 AR
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5
NA: NA Inflammatory diseases NA MAPK14
S00-T88: Injury, poisoning and certain other consequences of external causes Brain injury S09.90 APP
C00-D49: Neoplasms Breast cancer C50 AR; TERT; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; BCL2; KDR; KDR; KDR
G00-G99: Diseases of the nervous system G00-G99 Brain ischaemia G45.9, I67.8 PARP1
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
C00-D49: Neoplasms Advanced prostate cancer C61 AR
NA: NA Male hypogonadism NA AR
E00-E89: Endocrine, nutritional and metabolic diseases Male hormonal deficiencies E20-E35 AR
A00-B99: Certain infectious and parasitic diseases Malaria B54 CYP2D6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA; OPRD1; HTR2C; HTR2C
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Male sexual disorders F52 ADRA2C; DRD3
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR
K00-K95: Diseases of the digestive system Gastrointestinal disease K00-K93 ESRRA
K00-K95: Diseases of the digestive system Gastroesophageal reflux disease K21 TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Generalized anxiety disorder F32, F40-F42, F41.1 HTR2C
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Genetic disease Q00-Q99 ALPL
K00-K95: Diseases of the digestive system Diarrhea-predominant IBS K58.0 OPRD1
E00-E89: Endocrine, nutritional and metabolic diseases Dietary shortage E40-E46 PTGS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Drug abuse F10-F19 HTR2C; PPARG; DRD3
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cachexia R64 AR; ESRRA
C00-D49: Neoplasms Cancer C00-C96 AR; AKT1; MET; MCL1; CSNK2A1; ABCB1; FLT3; FLT3; CA9; MMP2; ACHE; DNMT1; SRC; IGF1R; PTK2; GSK3B; HIF1A; CDK1; MAPK1; MAPK14; MMP9; NFKB1; PIM1; PARP1; TLR2; BCL2; BCL2; TP53; CA1; KDR; APP
H00-H59: Diseases of the eye and adnexa Ocular inflammation H16.229 TERT; PPARG
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 ACHE; CA4; CA2
H00-H59: Diseases of the eye and adnexa Ocular disease H00-H59 ADRA2C
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
C00-D49: Neoplasms Lung cancer C33-C34 MMP2
H00-H59: Diseases of the eye and adnexa Macular degeneration H35.3 APP
J00-J99: Diseases of the respiratory system Asthma J45 PLA2G1B; ESRRA; TRPV1; ALOX5; ALOX5; ADORA2A; ADRA2C
C00-D49: Neoplasms Gliosarcoma NA FLT3
C00-D49: Neoplasms Glioma C71 KDR; APP
C00-D49: Neoplasms Glioblastoma NA FLT3
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; ACHE; ADORA2A; ADRA2C; CA1; CA1
NA: NA GIST NA FLT3
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; ABCC1; ABCC1; XDH; PPARG
G00-G99: Diseases of the nervous system G00-G99 Diagnostic imaging G30, I73.9 APP
L00-L99: Diseases of the skin and subcutaneous tissue Diabetic foot ulcer L88-L89 ADORA2A
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
H00-H59: Diseases of the eye and adnexa Diabetic retinopathy H36, E10.3, E11.3, E13.3 MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 ADRA2C
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
I00-I99: Diseases of the circulatory system Atherosclerosis I70 ALOX5; PPARD
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 MMP13; MMP3; MMP2; PTGS1; ALOX5
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 ADRA2C; CA4; CA4
C00-D49: Neoplasms Liver cancer C22 TERT; IGF1R; KDR
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A DNMT1; PTK2; TP53
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3; BCL2
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Erythema L51-L54 ADRA2C
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 PARP1
I00-I99: Diseases of the circulatory system Cerebral amyloid angiopathy I68.0 APP
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 DRD4
NA: NA Esophagus sensitivity NA TRPV1
C00-D49: Neoplasms Ovarian cancer C56 TERT; ABCB1; MMP2; PARP1; KDR; KDR; KDR; KDR
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 AR; SRC
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis in post-menopausal women M80-M81 AR
C00-D49: Neoplasms Osteosarcoma C40-C41 SRC; GSK3B
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC
I00-I99: Diseases of the circulatory system Ischemic heart diseases I20-I25 OPRD1
I00-I99: Diseases of the circulatory system Ischemic stroke I61-I63 MMP3
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; CA9; HIF1A; BCL2
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR
I00-I99: Diseases of the circulatory system Hypertension I10-I16 ADORA2A; ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 PPARD
H00-H59: Diseases of the eye and adnexa Choroidal neovascularisation H35 ESRRA
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 ACHE; CA1
NA: NA Chronic diarrhea associated with inflammatory bowel disease NA OPRD1
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 MPO; MAOA; ACHE; ADORA2A
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; TERT; FLT3; MMP2; TLR2; KDR
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 AR; PKM; MMP13; OPRD1; ACHE; TRPV1; TRPV1; PTGS1; IGF1R; ADORA2A; CDK1; ADRA2C; ADRA2A; HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CYP2D6; CA2
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 PTGS1; MAPK14; PPARG
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory skin condition L00-L99 PARP1
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MPO; PLA2G1B; MMP13; PTGS1; ALOX5; MAPK14
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 AR; AR; ESRRA; MMP2; PTGS1
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1
C00-D49: Neoplasms Hematological malignancies C81-C86 SRC; AURKB; TP53
NA: NA Hematopoietic stem cell transplantation NA FLT3
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Moderate-to-severe pain R52, G89 OPRD1
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 BCL2
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 SRC
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MPO; ALOX5; ADORA2A; MAPK14
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chronic pathological pain R52, G89 TRPV1
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 HTR2C; DRD3; DRD4
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
NA: NA Colour dead tissues NA PTPN1
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE
C00-D49: Neoplasms Myeloid leukemia C92 FLT3
C00-D49: Neoplasms Myelodysplastic syndrome D46 DNMT1; DNMT1; TLR2; KDR
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
C00-D49: Neoplasms Hormone refractory prostate cancer C61 AR
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 AR; IGF1R
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1
C00-D49: Neoplasms Metastasis C00-C97 AXL
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cocaine addiction F14.2 DRD3
C00-D49: Neoplasms CLL NA FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1; TRPV1; PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 FLT3; ALOX5; MAPK14; BCL2
NA: NA Primary insomnia NA HTR2C
C00-D49: Neoplasms Prostate cancer C61 AR; AR; TERT; FLT3; TLR2; BCL2
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 PLA2G1B; ALOX5
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 MMP3; PARP1
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
C00-D49: Neoplasms Castration-resistant prostate cancer C61 AR
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 AR; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Endocrine disease E00-E35 AR
C00-D49: Neoplasms Gastric cancer C16 KDR; KDR
K00-K95: Diseases of the digestive system Gastric motility disorder K22.4 DRD3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Female sexual dysfunction F52 DRD3
M00-M99: Diseases of the musculoskeletal system and connective tissue Fibromyalgia M79.7 ADRA2C
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5; RAB9A
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET
NA: NA HIV infections NA AHR
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 ALOX5
I00-I99: Diseases of the circulatory system Hypotension I95 ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Nicotine dependence F17 PPARG
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT; ACHE
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 ADRA2C; NPSR1; HTR2C; APP
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
C00-D49: Neoplasms Female androgenresponsive recurrent mammary cancer C50 AR
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
C00-D49: Neoplasms Recurrent epithelial ovarian or primary peritoneal cancer C78 PARP1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Radionuclide imaging W88 ADORA2A
S00-T88: Injury, poisoning and certain other consequences of external causes Radiation sickness T66 TLR2
C00-D49: Neoplasms Refractory renal cell carcinoma C64 PKM
C00-D49: Neoplasms Advanced melanoma C43 BCL2
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 PTPN1; ADRA2C; HTR2C; HTR2C; PPARG; PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 ESRRA
K00-K95: Diseases of the digestive system Non-alcoholic fatty liver disease K76.0 PPARG; PPARD
C00-D49: Neoplasms Non-small-cell lung cancer NA KDR
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; ABCB1; AXL; DNMT1; IGF1R; IGF1R; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Hypogonadism E23.0, E28.3, E29.1 AR
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Amyloidosis E85 APP
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ESRRA; PTGS1; ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue Dermatological disease L00-L99 AR; ESRRA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 ESRRA; HTR2C; DRD3; DRD4
C00-D49: Neoplasms Advanced breast cancer C50 CYP19A1; SRC
NA: NA Acute respiratory distress syndrome NA MAPK14
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

CMAUP

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Principle Investigator:
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Developer & Maintainer:
Dr. Zeng Xian
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