Plant Name: Pyrrosia tricuspis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 2.748E-06 | 3.325E-03 | CA2, CA7 |
| BP | GO:0065007; biological regulation | GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 5.494E-06 | 4.785E-03 | ADRA2A, ADRA2C |
| BP | GO:0009987; cellular process | GO:0032811; negative regulation of epinephrine secretion | 5.494E-06 | 4.785E-03 | ADRA2A, ADRA2C |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.741E-17 | 1.989E-13 | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.082E-15 | 9.068E-12 | CA1, CA12, CA2, CA4, CA6, CA7, CA9 |
| CC | GO:0044464; cell part | GO:0030424; axon | 4.004E-06 | 4.151E-03 | ADRA2C, APP, CA2, MAPK1, MAPT |
| MF | GO:0060089; molecular transducer activity | GO:0004938; alpha2-adrenergic receptor activity | 2.748E-06 | 3.325E-03 | ADRA2A, ADRA2C |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.370E-06 | 6.172E-03 | CA1, CA12, CA2, CA4, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 1.372E-05 | 9.335E-03 | CA1, CA2 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.010E-21 | 2.199E-17 | CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
Showing 1 to 10 of 10 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 5.284E-04 | 7.775E-03 | AKR1B10; AKR1B1 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 4.170E-04 | 7.775E-03 | AKR1B10; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 2.904E-06 | 1.495E-04 | AKR1B10; GAA; AKR1B1 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.417E-03 | 1.824E-02 | AKR1B10; AKR1B1 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.885E-21 | 2.972E-19 | CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14 |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 5.022E-04 | 7.775E-03 | MAPK1; ADRA2C; ADRA2A |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.161E-03 | 2.473E-02 | NMUR2; ADRA2C; ADRA2A |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 4.908E-03 | 4.676E-02 | ACHE; MAPK1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.994E-03 | 4.676E-02 | APP; MAPK1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.138E-04 | 7.339E-03 | CA2; CA4 |
Showing 1 to 10 of 11 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9; MAPK1; APP; ACHE |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; MAPK1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Glioma | C71 | APP |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1 |
Showing 1 to 10 of 70 entries