Plant Name: Rumex chalepensis
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; NMUR2; NPSR1; | |
| ADRA2C; ADRA2A; | |
| RECQL; TDP1; BLM; HPGD; HSD17B10; ALOX15; ALDH1A1; POLB; | |
| GAA; ACHE; | |
| FYN; MAPK1; EGFR; PIM1; CSNK2A1; | |
| CA2; CA1; CA12; CA9; CA5B; CA3; CA14; CA7; CA5A; CA4; CA6; | |
| ESR2; ESR1; | |
| KDM4E; | |
| ELANE; | |
| HIF1A; NFKB1; | |
| HTT; RAB9A; LMNA; MAPT; THPO; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
Showing 1 to 10 of 46 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.207E-10 | 9.160E-07 | CYP1A2, CYP2C9, CYP2D6, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.374E-08 | 2.301E-05 | CYP1A2, CYP2C9, CYP2D6, CYP3A4 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 9.933E-07 | 6.361E-04 | CA2, CA7, EGFR, HIF1A, HTT, MAPK1, NPSR1 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 1.496E-06 | 8.575E-04 | ADRA2A, CA2, CA7, EGFR, FYN, HIF1A, HTT, MAPK1, NPSR1 |
| BP | GO:0065007; biological regulation | GO:0010817; regulation of hormone levels | 2.640E-06 | 1.437E-03 | ACHE, ADRA2A, ADRA2C, ALDH1A1, CYP3A4, EGFR, ESR1, HIF1A, NFKB1 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 2.739E-06 | 1.455E-03 | CYP1A2, CYP2C9, CYP3A4 |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 5.480E-06 | 2.466E-03 | ADRA2A, CSNK2A1, EGFR, ELANE, ESR1, HIF1A, HPGD, MAPK1, PIM1, THPO, TSHR |
| BP | GO:0065007; biological regulation | GO:0043006; activation of phospholipase A2 activity by calcium-mediated signaling | 5.548E-06 | 2.466E-03 | EGFR, NMUR2 |
| BP | GO:0065007; biological regulation | GO:0030003; cellular cation homeostasis | 6.346E-06 | 2.679E-03 | CA2, CA7, ELANE, ESR1, HIF1A, HTT, MAPK1, NMUR2, NPSR1 |
| BP | GO:0008152; metabolic process | GO:0009822; alkaloid catabolic process | 1.662E-05 | 5.568E-03 | CYP2D6, CYP3A4 |
Showing 1 to 10 of 31 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 7.882E-03 | 2.936E-02 | CYP1A2; CYP3A4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.145E-02 | 3.205E-02 | CYP1A2 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 8.965E-03 | 3.106E-02 | CYP2C9; ALOX15 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 5.576E-07 | 4.154E-05 | CYP2C9; CYP1A2; ALOX15; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.496E-05 | 5.332E-04 | CYP2C9; CYP1A2; ALDH1A1; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.196E-26 | 4.762E-24 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 2.373E-05 | 5.332E-04 | CYP2C9; CYP2D6; CYP1A2; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.898E-05 | 5.332E-04 | CYP2C9; CYP2D6; CYP1A2; CYP3A4 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.214E-02 | 4.998E-02 | CYP2C9; GAA; CYP1A2; ALOX15; ALDH1A1; CYP3A4; HSD17B10 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 2.767E-03 | 1.586E-02 | MAPK1; MAPT; EGFR; NFKB1 |
Showing 1 to 10 of 66 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Septic shock | A41.9 | ELANE |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; CA9; EGFR |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | EGFR |
Showing 1 to 10 of 144 entries