GO Type |
GO Category |
Enriched GO Terms |
p-Value |
Adjusted p-Value |
Enriched Genes |
MF |
GO:0005488; binding
|
GO:0008270; zinc ion binding |
2.896E-12 |
2.102E-08 |
BLM, CA12, CA2, CA4, CA7, CA9, GLO1, KDM4A, KDM4C, KMT2A, L3MBTL1, MMP12, MMP2, MMP9, PARP1, TNKS, TP53 |
MF |
GO:0003824; catalytic activity
|
GO:0004089; carbonate dehydratase activity |
2.020E-10 |
7.813E-07 |
CA12, CA2, CA4, CA7, CA9 |
BP |
GO:0008152; metabolic process
|
GO:0055114; oxidation-reduction process |
1.697E-09 |
3.696E-06 |
AKR1B1, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, GSK3B, HSD17B10, KDM4A, KDM4C, KDM4E, MAOA, NOX4, XDH |
BP |
GO:0008152; metabolic process
|
GO:0006730; one-carbon metabolic process |
2.441E-08 |
2.743E-05 |
CA12, CA2, CA4, CA7, CA9 |
BP |
GO:0051179; localization
|
GO:0015701; bicarbonate transport |
6.930E-08 |
5.361E-05 |
CA12, CA2, CA4, CA7, CA9 |
MF |
GO:0005488; binding
|
GO:0005506; iron ion binding |
1.117E-07 |
7.845E-05 |
ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, XDH |
BP |
GO:0009987; cellular process
|
GO:0000733; DNA strand renaturation |
1.123E-06 |
5.092E-04 |
BLM, RECQL, TP53 |
BP |
GO:0050896; response to stimulus
|
GO:0042493; response to drug |
1.149E-06 |
5.106E-04 |
ABCG2, AKR1B1, BLM, CA9, CD38, CYP1A1, CYP1B1, POLB, SLC6A1, SLC6A11, TP53 |
BP |
GO:0008152; metabolic process
|
GO:0097267; omega-hydroxylase P450 pathway |
1.601E-06 |
6.704E-04 |
CYP1A1, CYP1A2, CYP1B1 |
BP |
GO:0009987; cellular process
|
GO:0009967; positive regulation of signal transduction |
1.698E-06 |
6.976E-04 |
AKR1B1, ALOX15, APP, CYP1B1, FLT3, GSK3B, HIF1A, MMP12, MMP9, NOX4, PARP1, TNKS, TNKS2, TP53, XDH |
BP |
GO:0050896; response to stimulus
|
GO:0001666; response to hypoxia |
2.859E-06 |
1.132E-03 |
CD38, CYP1A1, HIF1A, LMNA, MMP2, NOX4, TP53 |
MF |
GO:0005488; binding
|
GO:0019825; oxygen binding |
4.260E-06 |
1.592E-03 |
CYP1A1, CYP1A2, CYP1B1, NOX4 |
MF |
GO:0003824; catalytic activity
|
GO:0032454; histone demethylase activity (H3-K9 specific) |
4.823E-06 |
1.616E-03 |
KDM4A, KDM4C, KDM4E |
BP |
GO:0008152; metabolic process
|
GO:2001303; lipoxin A4 biosynthetic process |
5.795E-06 |
1.829E-03 |
ALOX12, ALOX15 |
MF |
GO:0003824; catalytic activity
|
GO:0047977; hepoxilin-epoxide hydrolase activity |
5.795E-06 |
1.829E-03 |
ALOX12, ALOX15 |
BP |
GO:0008152; metabolic process
|
GO:0033169; histone H3-K9 demethylation |
6.018E-06 |
1.872E-03 |
KDM4A, KDM4C, KDM4E |
BP |
GO:0008152; metabolic process
|
GO:0019372; lipoxygenase pathway |
7.395E-06 |
2.147E-03 |
ALOX12, ALOX15, ALOX5 |
BP |
GO:0050896; response to stimulus
|
GO:0010332; response to gamma radiation |
8.899E-06 |
2.439E-03 |
NOX4, PARP1, POLB, TP53 |
BP |
GO:0009987; cellular process
|
GO:0032849; positive regulation of cellular pH reduction |
1.736E-05 |
3.983E-03 |
CA2, CA7 |
BP |
GO:0050896; response to stimulus
|
GO:0055093; response to hyperoxia |
1.741E-05 |
3.983E-03 |
CYP1A1, POLB, TP53 |
BP |
GO:0008152; metabolic process
|
GO:0019373; epoxygenase P450 pathway |
1.741E-05 |
3.983E-03 |
CYP1A1, CYP1A2, CYP1B1 |
MF |
GO:0003824; catalytic activity
|
GO:0004052; arachidonate 12-lipoxygenase activity |
1.736E-05 |
3.983E-03 |
ALOX12, ALOX15 |
MF |
GO:0003824; catalytic activity
|
GO:0051120; hepoxilin A3 synthase activity |
1.736E-05 |
3.983E-03 |
ALOX12, ALOX15 |
BP |
GO:0008152; metabolic process
|
GO:1901564; organonitrogen compound metabolic process |
1.820E-05 |
4.044E-03 |
ABCG2, AKR1B1, APP, CD38, CYP1A1, CYP1A2, FLT3, GLO1, GSK3B, HIF1A, HSD17B10, KDM4A, KDM4C, KDM4E, KMT2A, MAOA, MMP12, MMP2, MMP9, NOX4, PARP1, POLB, TNKS, TNKS2, TP53, TTR, XDH |
MF |
GO:0005488; binding
|
GO:0042802; identical protein binding |
2.090E-05 |
4.598E-03 |
ABCG2, APP, BLM, CD38, FLT3, KMT2A, L3MBTL1, MMP9, PARP1, SMN1, SMN2, TP53, TTR, XDH |
BP |
GO:0008152; metabolic process
|
GO:0009404; toxin metabolic process |
2.311E-05 |
4.933E-03 |
CYP1A1, CYP1A2, CYP1B1 |
MF |
GO:0003824; catalytic activity
|
GO:0070330; aromatase activity |
2.311E-05 |
4.933E-03 |
CYP1A1, CYP1A2, CYP1B1 |
MF |
GO:0005488; binding
|
GO:0002039; p53 binding |
2.508E-05 |
5.250E-03 |
BLM, GSK3B, HIF1A, TP53 |
BP |
GO:0008152; metabolic process
|
GO:0070213; protein auto-ADP-ribosylation |
3.466E-05 |
6.410E-03 |
TNKS, TNKS2 |
BP |
GO:0008152; metabolic process
|
GO:0018894; dibenzo-p-dioxin metabolic process |
3.466E-05 |
6.410E-03 |
CYP1A1, CYP1A2 |
MF |
GO:0003824; catalytic activity
|
GO:0003950; NAD+ ADP-ribosyltransferase activity |
3.375E-05 |
6.410E-03 |
PARP1, TNKS, TNKS2 |
MF |
GO:0005215; transporter activity
|
GO:0005332; gamma-aminobutyric acid:sodium symporter activity |
3.466E-05 |
6.410E-03 |
SLC6A1, SLC6A11 |
BP |
GO:0065007; biological regulation
|
GO:1904357; negative regulation of telomere maintenance via telomere lengthening |
3.791E-05 |
6.765E-03 |
PARP1, TNKS, TNKS2 |
BP |
GO:0050896; response to stimulus
|
GO:1904646; cellular response to amyloid-beta |
3.791E-05 |
6.765E-03 |
APP, GSK3B, PARP1 |
CC |
GO:0043226; organelle
|
GO:0043231; intracellular membrane-bounded organelle |
4.081E-05 |
7.224E-03 |
ABCG2, AKR1B1, APP, BLM, CA4, CD38, CYP1A1, CYP1A2, CYP1B1, FLT3, GLO1, GSK3B, HIF1A, HSD17B10, KDM4A, KDM4E, KMT2A, L3MBTL1, LMNA, MAOA, MMP12, MMP2, NOX4, PARP1, POLB, RECQL, SMN1, SMN2, TDP1, TNKS, TNKS2, TP53, XDH |
BP |
GO:0065007; biological regulation
|
GO:0060249; anatomical structure homeostasis |
4.402E-05 |
7.607E-03 |
AKR1B1, BLM, HIF1A, KMT2A, NOX4, PARP1 |
BP |
GO:0050896; response to stimulus
|
GO:0033993; response to lipid |
5.159E-05 |
8.409E-03 |
CA2, CA9, CD38, CYP1A1, CYP1A2, FLT3, PARP1, SLC6A1, TP53 |
BP |
GO:0008152; metabolic process
|
GO:2000377; regulation of reactive oxygen species metabolic process |
5.506E-05 |
8.749E-03 |
CYP1B1, HIF1A, NOX4, TP53, XDH |
BP |
Unclassified;
|
GO:0044259; multicellular organismal macromolecule metabolic process |
5.645E-05 |
8.749E-03 |
HIF1A, MMP12, MMP2, MMP9 |
BP |
GO:0008152; metabolic process
|
GO:0051122; hepoxilin biosynthetic process |
5.768E-05 |
8.749E-03 |
ALOX12, ALOX15 |
BP |
GO:0008152; metabolic process
|
GO:1900113; negative regulation of histone H3-K9 trimethylation |
5.768E-05 |
8.749E-03 |
KDM4A, KDM4C |
BP |
GO:0008152; metabolic process
|
GO:0006691; leukotriene metabolic process |
5.785E-05 |
8.749E-03 |
ALOX12, ALOX15, ALOX5 |
MF |
GO:0003824; catalytic activity
|
GO:0009378; four-way junction helicase activity |
5.768E-05 |
8.749E-03 |
BLM, RECQL |
BP |
GO:0002376; immune system process
|
GO:0030097; hemopoiesis |
6.456E-05 |
9.434E-03 |
FLT3, HIF1A, KMT2A, L3MBTL1 |