Plant Name: Clusia multiflora
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR35; | |
| TDP1; RECQL; BLM; HPGD; AKR1B1; HSD17B10; ALOX15; USP2; APEX1; POLB; | |
| DUSP3; | |
| GAA; | |
| BRAF; FLT4; TEK; PDGFRB; GSK3B; AKT1; MET; PLK4; INSR; ERBB2; EGFR; AURKB; NUAK1; EPHB4; AURKA; PLK1; KDR; SRC; IGF1R; MAP3K8; PTK2; CSNK2A1; | |
| CA2; CA12; CA13; CA14; CA5A; CA7; CA4; CA6; | |
| KDM4E; | |
| BACE1; | |
| SLC22A6; | |
| SMAD3; LMNA; HBB; HSPA1A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Showing 1 to 10 of 50 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.963E-12 | 2.212E-09 | CA12, CA13, CA2, CA4, CA5A, CA6, CA7 |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 2.185E-09 | 5.663E-07 | EGFR, IGF1R, INSR, KDR, PTK2, SRC |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 4.958E-09 | 1.149E-06 | EGFR, ERBB2, INSR, MET, PDGFRB, PTK2, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0070374; positive regulation of ERK1 and ERK2 cascade | 3.777E-08 | 6.970E-06 | ALOX15, BRAF, EGFR, FLT4, KDR, PDGFRB, SRC, TEK |
| BP | GO:0008152; metabolic process | GO:0045429; positive regulation of nitric oxide biosynthetic process | 6.610E-08 | 1.152E-05 | AKT1, EGFR, HBB, INSR, SMAD3 |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 2.406E-07 | 3.553E-05 | AKT1, APEX1, BLM, BRAF, CA2, CSNK2A1, EGFR, HPGD, PDGFRB, SLC22A6, SRC, TEK |
| BP | GO:0009987; cellular process | GO:0051495; positive regulation of cytoskeleton organization | 6.638E-07 | 8.259E-05 | ALOX15, BRAF, HSPA1A, MET, PLK4, SMAD3, TEK |
| BP | GO:0008152; metabolic process | GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity | 1.036E-06 | 1.226E-04 | PDGFRB, PTK2, SRC, TEK |
| BP | GO:0032501; multicellular organismal process | GO:0003007; heart morphogenesis | 1.354E-06 | 1.544E-04 | EPHB4, GAA, INSR, PTK2 |
| BP | GO:0008283; cell proliferation | GO:0048661; positive regulation of smooth muscle cell proliferation | 1.523E-06 | 1.717E-04 | AKR1B1, AKT1, EGFR, HPGD, PDGFRB |
Showing 1 to 10 of 71 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 2.548E-03 | 7.430E-03 | GAA; AKR1B1 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.024E-17 | 2.935E-15 | CA12; CA2; CA5A; CA4; CA7; CA6; CA14; CA13 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 3.078E-03 | 8.751E-03 | POLB; APEX1 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 3.157E-06 | 2.495E-05 | PDGFRB; DUSP3; AKT1; BRAF; MAP3K8; EGFR; HSPA1A |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.979E-09 | 3.586E-08 | GSK3B; SRC; ERBB2; AKT1; BRAF; EGFR; PTK2 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 4.461E-09 | 6.469E-08 | PDGFRB; INSR; FLT4; KDR; AKT1; TEK; MET; EGFR; IGF1R |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 3.616E-12 | 1.748E-10 | PDGFRB; SRC; INSR; FLT4; KDR; AKT1; BRAF; TEK; MET; EGFR; IGF1R |
| hsa04020 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.031E-02 | 2.135E-02 | PDGFRB; ERBB2; EGFR |
| hsa04060 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 5.120E-04 | 2.062E-03 | PDGFRB; FLT4; KDR; MET; EGFR |
| hsa04062 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.020E-04 | 5.856E-04 | GSK3B; SRC; AKT1; BRAF; PTK2 |
Showing 1 to 10 of 73 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR; EGFR |
| C00-D49: Neoplasms | Metastatic melanoma | C43 | BRAF; BRAF |
| C00-D49: Neoplasms | Urethral cancer | NA | EGFR |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR; BRAF |
| C00-D49: Neoplasms | Melanoma | C43 | KDR; KDR; EGFR; BRAF |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| C00-D49: Neoplasms | Malignant tumor | C00-C75, C7A, C7B | EGFR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | FLT4; TEK; PDGFRB; AKT1; MET; KDR; KDR; KDR; SRC; ERBB2; EGFR; PLK1; PLK1; IGF1R; PTK2; AURKB; AURKA |
Showing 1 to 10 of 123 entries