| ICD10 Disease Category |
Disease Name |
ICD10 Code |
Linked Targets |
| NA: NA |
Dyslipidemia |
NA |
HMGCR |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Hypercholesterolemia |
E78 |
HMGCR |
| C00-D49: Neoplasms |
Acute myeloid leukemia |
C92.0 |
TP53; TP53 |
| G00-G99: Diseases of the nervous system G00-G99 |
Central nervous system disease |
G00-G99 |
MAPT |
| NA: NA |
Hyperlipidemia |
NA |
HMGCR |
| K00-K95: Diseases of the digestive system |
Chemotherapy or radiotherapy-induced mucositis |
K12.3, R52, G89 |
HMGCR |
| C00-D49: Neoplasms |
Hematological malignancies |
C81-C86 |
TP53 |
| G00-G99: Diseases of the nervous system G00-G99 |
Neurodegenerative disease |
G30-G32 |
MAPT |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Cognitive disorders |
F01-F07, F04, F05, R41.3 |
MAPT |
| I00-I99: Diseases of the circulatory system |
Thrombosis |
I80-I82 |
HMGCR |
| A00-B99: Certain infectious and parasitic diseases |
HBV infection |
B16, B18.0, B18.1 |
HMGCR |
| C00-D49: Neoplasms |
Late-stage solid tumors |
C00-C75, C7A, C7B, D10-D36, D3A |
TP53 |
| H60-H95: Diseases of the ear and mastoid process |
Hearing disorder |
H90.5 |
TP53 |
| C00-D49: Neoplasms |
Head and neck cancer |
C07-C14, C32-C33 |
TP53 |
| I00-I99: Diseases of the circulatory system |
Renal artery disease |
I70.1 |
TP53 |
| C00-D49: Neoplasms |
Cancer |
C00-C96 |
TP53 |
| I00-I99: Diseases of the circulatory system |
Cardiovascular disorder |
I00-I99 |
HMGCR |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Elevated CRP |
E78.0 |
HMGCR |
| I00-I99: Diseases of the circulatory system |
Myocardial infarction |
I21, I22 |
HMGCR |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Dyslipidaemias |
E78 |
HMGCR |
| NA: NA |
Cardiovascular disease |
NA |
HMGCR |
| C00-D49: Neoplasms |
Oral cavity cancer |
C00-C08 |
TP53 |
| C00-D49: Neoplasms |
Multiple myeloma |
C90 |
HMGCR |
| I00-I99: Diseases of the circulatory system |
Atherosclerosis |
I70 |
HMGCR |
| I00-I99: Diseases of the circulatory system |
Arteriosclerosis |
I70 |
HMGCR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders |
Anxiety disorder |
F32, F40-F42 |
CYP3A4 |
| G00-G99: Diseases of the nervous system G00-G99 |
Spinal muscular atrophy |
G00-G99 |
SMN1;SMN2 |
| C00-D49: Neoplasms |
Solid tumours |
C00-D48 |
TP53 |
| I00-I99: Diseases of the circulatory system |
Cerebrovascular ischaemia |
I61-I63 |
HMGCR |
| G00-G99: Diseases of the nervous system G00-G99 |
Alzheimer disease |
G30 |
MAPT |
| C00-D49: Neoplasms |
Colorectal cancer |
C18-C21 |
TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Hyperlipidaemia |
E78 |
HMGCR |
| S00-T88: Injury, poisoning and certain other consequences of external causes |
Toxicity |
T36-T50, T51-T65 |
TP53 |
