Plant Name: Astragalus adsurgens
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.660E-09 | 7.969E-05 | CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 4.017E-08 | 4.276E-04 | CYP2C19, CYP2C9, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 8.300E-08 | 4.518E-04 | CA12, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 2.417E-07 | 1.053E-03 | CYP2C19, CYP2C9, CYP3A4, HSD17B2, NPC1 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.084E-06 | 2.951E-03 | CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.293E-06 | 3.128E-03 | CA12, CA4, CA7 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 2.121E-06 | 4.199E-03 | CYP2C9, CYP3A4 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 2.392E-06 | 4.291E-03 | CA12, CA4, CA7 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 2.561E-06 | 4.291E-03 | CYP2C19, CYP2C9, CYP3A4 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.117E-07 | 2.681E-06 | CA12; CA4; CA7 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 5.977E-07 | 7.173E-06 | CYP2C9; CYP3A4; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 7.059E-06 | 5.073E-05 | CYP2C9; ALDH1A1; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 8.456E-06 | 5.073E-05 | CYP2C9; CYP3A4; CYP2C19 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.423E-05 | 6.830E-05 | CYP2C9; CYP3A4; CYP2C19 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 4.965E-04 | 1.835E-03 | CYP2C9; HSD17B2; ALDH1A1; CYP2C19; CYP3A4 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 6.117E-04 | 1.835E-03 | CYP2C9; CYP2C19 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 5.354E-04 | 1.835E-03 | HSD17B2; CYP3A4 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 8.470E-04 | 2.259E-03 | CYP2C9; CYP3A4 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.978E-03 | 4.746E-03 | CYP2C9; CYP2C19 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.372E-02 | 2.993E-02 | CA4 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; CA4 |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |