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Plant Name: Dumortiera hirsuta




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
GPR35; GPBAR1; DRD4;
Peptide receptor (family A GPCR)
NPSR1; CXCR1;
Enzyme_unclassified
ALPL; RECQL; TDP1; PLA2G1B; ALPI; APOBEC3G; PKM; PIK3CA; PIK3CG; PIK3CB; PIK3R1; GLO1; HPGD; PGD; MPO; AKR1B1; HSD17B2; HSD17B10; ALOX15; NQO2; AKR1B10; ALDH1A1; ALOX12; GFER; NOX4; USP2; PYGL; APEX1; POLB; CD38;
Protein Phosphatase
PTPN1; CDC25B; PTPN2;
Hydrolase
ACHE; GAA;
Histone deacetylase
HDAC3;
Miscellaneous ion channel
BCL2;
Isomerase
TOP2A;
Protein Kinase
NEK6; AKT1; MET; CAMK2B; BCR; INSR; CSNK2A1; DAPK1; SYK; AXL; NEK2; FLT3; MYLK; SRC; IGF1R; AURKB; GSK3B; CDK1; MAPK14; PIM1; NUAK1; ALK; PTK2; KDR; PKN1;
Lyase
CA7; CA3; CA14; CA5B; CA5A; CA12; CA9; CA13; CA4; CA6; CA2; CA1;
Nuclear hormone receptor subfamily 3 group A
ESR1; ESR2;
Nuclear hormone receptor subfamily 1 group H
NR1H4;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; PTGS1; PTGS2; XDH;
Metallo protease
MMP13; MMP3; MMP2; MMP9;
Aspartic protease
BACE1;
Transcription Factor
STAT6; HIF1A; NFKB1; TP53;
ATP-binding cassette
ABCC1; ABCG2;
SLC superfamily of solute carriers
SLC6A2; SLCO1B3; SLCO1B1;
Unclassified
LMNA; MAPT; GMNN; THPO; HTT; RAB9A; NPC1; APP;
Methyl-lysine/arginine binding protein
L3MBTL1;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified USP2 Ubiquitin carboxyl-terminal hydrolase 2 O75604 CHEMBL1293227
Enzyme_unclassified PYGL Liver glycogen phosphorylase P06737 CHEMBL2568
Enzyme_unclassified APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified CD38 Lymphocyte differentiation antigen CD38 P28907 CHEMBL4660
Enzyme_unclassified ALPL Alkaline phosphatase, tissue-nonspecific isozyme P05186 CHEMBL5979
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified PLA2G1B Phospholipase A2 group 1B P04054 CHEMBL4426
Enzyme_unclassified ALPI Intestinal alkaline phosphatase P09923 CHEMBL5573
Enzyme_unclassified APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Q9HC16 CHEMBL1741217
Enzyme_unclassified PKM Pyruvate kinase isozymes M1/M2 P14618 CHEMBL1075189
Enzyme_unclassified PIK3CA PI3-kinase p110-alpha subunit P42336 CHEMBL4005
Enzyme_unclassified PIK3CG PI3-kinase p110-gamma subunit P48736 CHEMBL3267
Enzyme_unclassified PIK3CB PI3-kinase p110-beta subunit P42338 CHEMBL3145
Enzyme_unclassified PIK3R1 PI3-kinase p85-alpha subunit P27986 CHEMBL2506
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Enzyme_unclassified PGD 6-phosphogluconate dehydrogenase P52209 CHEMBL3404
Enzyme_unclassified MPO Myeloperoxidase P05164 CHEMBL2439
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified NQO2 Quinone reductase 2 P16083 CHEMBL3959
Enzyme_unclassified AKR1B10 Aldo-keto reductase family 1 member B10 O60218 CHEMBL5983
Enzyme_unclassified ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified GFER FAD-linked sulfhydryl oxidase ALR P55789 CHEMBL1741189
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Histone deacetylase HDAC3 Histone deacetylase 3 O15379 CHEMBL1829
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Isomerase TOP2A DNA topoisomerase II alpha P11388 CHEMBL1806
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA13 Carbonic anhydrase XIII Q8N1Q1 CHEMBL3912
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP13 Matrix metalloproteinase 13 P45452 CHEMBL280
Metallo protease MMP3 Matrix metalloproteinase 3 P08254 CHEMBL283
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Miscellaneous ion channel BCL2 Apoptosis regulator Bcl-2 P10415 CHEMBL4860
Nuclear hormone receptor subfamily 1 group H NR1H4 Bile acid receptor FXR Q96RI1 CHEMBL2047
Nuclear hormone receptor subfamily 3 group A ESR1 Estrogen receptor alpha P03372 CHEMBL206
Nuclear hormone receptor subfamily 3 group A ESR2 Estrogen receptor beta Q92731 CHEMBL242
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase PTGS1 Cyclooxygenase-1 P23219 CHEMBL221
Oxidoreductase PTGS2 Cyclooxygenase-2 P35354 CHEMBL230
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A P25024 CHEMBL4029
Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 Q9HC98 CHEMBL4309
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase CAMK2B CaM kinase II beta Q13554 CHEMBL4121
Protein Kinase BCR Bcr/Abl fusion protein P11274 CHEMBL2096618
Protein Kinase INSR Insulin receptor P06213 CHEMBL1981
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase DAPK1 Death-associated protein kinase 1 P53355 CHEMBL2558
Protein Kinase SYK Tyrosine-protein kinase SYK P43405 CHEMBL2599
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 P51955 CHEMBL3835
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase MYLK Myosin light chain kinase, smooth muscle Q15746 CHEMBL2428
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK14 MAP kinase p38 alpha Q16539 CHEMBL260
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase PKN1 Protein kinase N1 Q16512 CHEMBL3384
Protein Phosphatase PTPN1 Protein-tyrosine phosphatase 1B P18031 CHEMBL335
Protein Phosphatase CDC25B Dual specificity phosphatase Cdc25B P30305 CHEMBL4804
Protein Phosphatase PTPN2 T-cell protein-tyrosine phosphatase P17706 CHEMBL3807
SLC superfamily of solute carriers SLC6A2 Norepinephrine transporter P23975 CHEMBL222
SLC superfamily of solute carriers SLCO1B3 Solute carrier organic anion transporter family member 1B3 Q9NPD5 CHEMBL1743121
SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 Q9Y6L6 CHEMBL1697668
Small molecule receptor (family A GPCR) GPR35 G-protein coupled receptor 35 Q9HC97 CHEMBL1293267
Small molecule receptor (family A GPCR) GPBAR1 G-protein coupled bile acid receptor 1 Q8TDU6 CHEMBL5409
Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor P21917 CHEMBL219
Transcription Factor STAT6 Signal transducer and activator of transcription 6 P42226 CHEMBL5401
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified GMNN Geminin O75496 CHEMBL1293278
Unclassified THPO Thrombopoietin P40225 CHEMBL1293256
Unclassified HTT Huntingtin P42858 CHEMBL5514
Unclassified RAB9A Ras-related protein Rab-9A P51151 CHEMBL1293294
Unclassified NPC1 Niemann-Pick C1 protein O15118 CHEMBL1293277
Unclassified APP Beta amyloid A4 protein P05067 CHEMBL2487
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
MF GO:0005488; binding GO:0020037; heme binding 1.228E-12 3.991E-10 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, MPO, NOX4, PTGS1, PTGS2, SRC
MF GO:0005488; binding GO:0005524; ATP binding 2.163E-12 6.543E-10 ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, BCR, CAMK2B, CDK1, CSNK2A1, DAPK1, FLT3, GSK3B, IGF1R, INSR, KDR, MAPK14, MET, MYLK, NEK2, NEK6, NUAK1, PIK3CA, PIK3CB, PIK3CG, PIM1, PKM, PKN1, PTK2, PYGL, RECQL, SRC, SYK, TOP2A, TP53
MF GO:0005488; binding GO:0019825; oxygen binding 7.467E-12 1.959E-09 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, NOX4
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 1.043E-11 2.671E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
MF GO:0005488; binding GO:0008270; zinc ion binding 2.618E-11 6.265E-09 ALPI, APOBEC3G, CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, GLO1, L3MBTL1, MMP13, MMP2, MMP3, MMP9, NQO2, NR1H4, PTPN1, TP53
MF GO:0003824; catalytic activity GO:0004674; protein serine/threonine kinase activity 4.899E-11 1.036E-08 AKT1, ALK, AURKB, BCR, CAMK2B, CDK1, CSNK2A1, DAPK1, GSK3B, MAPK14, MYLK, NEK2, NEK6, NUAK1, PIK3CA, PIK3CG, PIM1, PKN1, SYK
BP Unclassified; GO:0032846; positive regulation of homeostatic process 1.348E-10 2.552E-08 AURKB, CA2, CA7, HIF1A, HTT, MAPK14, NEK2, NPC1, NPSR1, NR1H4, PIK3CB, PLA2G1B, PTGS2, SYK
MF GO:0005488; binding GO:0005506; iron ion binding 3.358E-10 5.897E-08 ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, XDH
BP Unclassified; GO:0032844; regulation of homeostatic process 8.468E-10 1.308E-07 AURKB, BCL2, CA2, CA7, CD38, HIF1A, HTT, KDR, MAPK14, NEK2, NPC1, NPSR1, NR1H4, PIK3CB, PLA2G1B, PTGS2, SRC, SYK
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 1.417E-09 1.965E-07 CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 2.548E-09 3.363E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 2.769E-09 3.610E-07 AXL, INSR, MET, NOX4, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PTK2, SRC, THPO
MF GO:0005488; binding GO:0043560; insulin receptor substrate binding 3.816E-09 4.748E-07 IGF1R, INSR, PIK3CA, PIK3CB, PIK3R1
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 4.693E-09 5.584E-07 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 6.509E-09 7.499E-07 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0009987; cellular process GO:0048010; vascular endothelial growth factor receptor signaling pathway 1.506E-08 1.647E-06 AXL, KDR, MAPK14, PIK3CA, PIK3CB, PIK3R1, PTK2, SRC
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 2.105E-08 2.203E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 3.519E-08 3.483E-06 ALOX12, ALOX15, ALOX5, HPGD, PTGS2
CC GO:0044464; cell part GO:0005829; cytosol 1.111E-07 1.008E-05 AKR1B1, AKR1B10, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APOBEC3G, APP, AURKB, BCL2, BCR, CA1, CA13, CA2, CA3, CA7, CAMK2B, CDC25B, CDK1, CSNK2A1, FLT3, GFER, GLO1, GMNN, GSK3B, HDAC3, HIF1A, HPGD, HTT, LMNA, MAPK14, MAPT, MYLK, NEK2, NEK6, NFKB1, NQO2, PGD, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIM1, PKM, PKN1, PLA2G1B, PTK2, PTPN1, PTPN2, PYGL, RAB9A, SRC, STAT6, SYK, TP53, XDH
BP GO:0009987; cellular process GO:0043065; positive regulation of apoptotic process 2.189E-07 1.891E-05 AKT1, BCL2, CYP1B1, DAPK1, GSK3B, HPGD, HTT, MAPT, MMP9, NOX4, PIK3CB, PTGS2, PTPN2, SRC, TOP2A, TP53, XDH
BP GO:0009987; cellular process GO:0030168; platelet activation 4.236E-07 3.454E-05 AKT1, AXL, PIK3CA, PIK3CB, PIK3CG, PIK3R1, SRC, SYK
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 4.421E-07 3.592E-05 IGF1R, INSR, KDR, PTK2, SRC, SYK
BP GO:0008152; metabolic process GO:0018107; peptidyl-threonine phosphorylation 5.492E-07 4.381E-05 AKT1, BCL2, CAMK2B, CDK1, CSNK2A1, GSK3B, PKN1
BP GO:0032502; developmental process GO:0001525; angiogenesis 5.810E-07 4.600E-05 CYP1B1, HIF1A, KDR, MAPK14, MMP2, PIK3CA, PIK3CB, PIK3CG, PTGS2, PTK2, SYK
BP GO:0065007; biological regulation GO:0042593; glucose homeostasis 6.632E-07 5.067E-05 AKT1, HIF1A, INSR, NOX4, NR1H4, PIK3CA, PIK3R1, PTPN2, PYGL
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 6.747E-07 5.137E-05 CYP1A2, CYP2C8, CYP2C9, CYP3A4
MF GO:0005488; binding GO:0051721; protein phosphatase 2A binding 7.460E-07 5.582E-05 AKT1, BCL2, MAPT, PTPN1, TP53
BP GO:0048511; rhythmic process GO:0048511; rhythmic process 1.608E-06 1.126E-04 AXL, BCL2, CSNK2A1, DRD4, ESR1, GSK3B, HDAC3, SRC, TOP2A, TP53, USP2
BP GO:0009987; cellular process GO:2001243; negative regulation of intrinsic apoptotic signaling pathway 2.106E-06 1.446E-04 AKT1, BCL2, HIF1A, MMP9, PTGS2, PTPN1, SRC
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 2.130E-06 1.452E-04 AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 2.317E-06 1.562E-04 CYP1A1, CYP2C8, CYP3A4
BP GO:0009987; cellular process GO:2000811; negative regulation of anoikis 2.434E-06 1.631E-04 BCL2, PIK3CA, PTK2, SRC
BP GO:0022610; biological adhesion GO:0001952; regulation of cell-matrix adhesion 3.624E-06 2.335E-04 BCL2, GSK3B, KDR, PIK3CB, PIK3R1, PTK2, SRC
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 3.866E-06 2.476E-04 AKT1, BCL2, HIF1A, LMNA, PTGS2, SRC, TP53
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 4.613E-06 2.887E-04 CYP1A1, CYP2C8, CYP3A4
BP GO:0051179; localization GO:0046326; positive regulation of glucose import 6.782E-06 4.091E-04 AKT1, INSR, MAPK14, NR1H4, PIK3R1
BP GO:0032501; multicellular organismal process GO:0043536; positive regulation of blood vessel endothelial cell migration 7.614E-06 4.518E-04 AKT1, HIF1A, KDR, MAPK14, PTGS2
BP GO:0050896; response to stimulus GO:0071498; cellular response to fluid shear stress 7.813E-06 4.598E-04 CA2, HDAC3, PTGS2, SRC
MF GO:0003824; catalytic activity GO:0035005; 1-phosphatidylinositol-4-phosphate 3-kinase activity 8.037E-06 4.658E-04 PIK3CA, PIK3CB, PIK3CG
BP GO:0050896; response to stimulus GO:0046626; regulation of insulin receptor signaling pathway 1.304E-05 7.301E-04 NR1H4, PIK3R1, PTPN1, PTPN2, SRC
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 8.415E-25 9.162E-21 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF GO:0005488; binding GO:0032052; bile acid binding 1.911E-05 1.030E-03 NR1H4, PLA2G1B, PYGL
MF Unclassified; GO:0004716; signal transducer, downstream of receptor, with protein tyrosine kinase activity 1.911E-05 1.030E-03 INSR, KDR, SYK
MF GO:0005488; binding GO:0043548; phosphatidylinositol 3-kinase binding 2.984E-05 1.540E-03 AXL, IGF1R, INSR, PIK3R1
BP GO:0051179; localization GO:0042307; positive regulation of protein import into nucleus 3.349E-05 1.702E-03 APP, CDK1, HDAC3, MAPK14, PIK3R1, PTGS2
CC GO:0043226; organelle GO:0005654; nucleoplasm 3.702E-05 1.849E-03 AKR1B1, AKT1, ALOX5, APEX1, AURKB, BCL2, CAMK2B, CDC25B, CDK1, CSNK2A1, ESR1, ESR2, GMNN, GSK3B, HDAC3, HIF1A, HPGD, HTT, L3MBTL1, LMNA, MAPK14, NEK2, NEK6, NFKB1, NQO2, NR1H4, NUAK1, PIM1, PKN1, POLB, PTPN2, RECQL, SRC, STAT6, TOP2A, TP53, USP2
MF GO:0005488; binding GO:0034452; dynactin binding 3.721E-05 1.854E-03 GSK3B, HTT, MAPT
BP GO:0009987; cellular process GO:0006286; base-excision repair, base-free sugar-phosphate removal 3.828E-05 1.869E-03 APEX1, POLB
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 3.828E-05 1.869E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0004666; prostaglandin-endoperoxide synthase activity 3.828E-05 1.869E-03 PTGS1, PTGS2
MF GO:0060089; molecular transducer activity GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding 3.828E-05 1.869E-03 ESR1, ESR2
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 3.828E-05 1.869E-03 ALOX12, ALOX15
CC GO:0044464; cell part GO:0005739; mitochondrion 4.343E-05 2.074E-03 AKT1, APEX1, BCL2, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, ESR2, GFER, GSK3B, HSD17B10, MAOA, MAPK14, MMP2, MPO, NFKB1, NOX4, PKM, SRC, TP53
BP GO:0009987; cellular process GO:2001237; negative regulation of extrinsic apoptotic signaling pathway 4.436E-05 2.094E-03 AKT1, BCL2, DAPK1, HTT, LMNA, SRC
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 4.453E-05 2.094E-03 CSNK2A1, HIF1A, KDR, MAPT
BP Unclassified; GO:2000021; regulation of ion homeostasis 4.732E-05 2.221E-03 BCL2, CA2, CA7, HTT, KDR, NPSR1, PLA2G1B, SRC
BP GO:0008152; metabolic process GO:0010907; positive regulation of glucose metabolic process 5.043E-05 2.336E-03 AKT1, INSR, PTPN2, SRC
BP Unclassified; GO:0044236; multicellular organism metabolic process 5.213E-05 2.398E-03 HIF1A, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0009987; cellular process GO:0007569; cell aging 5.219E-05 2.398E-03 BCL2, CDK1, MAPK14, NOX4, TP53
BP GO:0008152; metabolic process GO:0006081; cellular aldehyde metabolic process 5.219E-05 2.398E-03 AKR1B10, ALDH1A1, CYP1B1, GLO1, PGD
MF GO:0003824; catalytic activity GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity 5.619E-05 2.555E-03 MET, PIK3CA, PIK3CB, PIK3CG, PIK3R1
MF GO:0005488; binding GO:0042826; histone deacetylase binding 5.789E-05 2.610E-03 GMNN, HDAC3, HIF1A, PKN1, TOP2A, TP53
MF GO:0003824; catalytic activity GO:0009055; electron transfer activity 5.789E-05 2.610E-03 AKR1B1, CYP19A1, CYP1A2, NOX4, NQO2, XDH
BP GO:0009987; cellular process GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response 6.391E-05 2.834E-03 PIK3R1, PTPN1, PTPN2
BP GO:0051179; localization GO:0030100; regulation of endocytosis 6.800E-05 3.004E-03 ALOX15, APP, AXL, BCR, PIK3CB, PTPN1, SRC, SYK
BP GO:0050896; response to stimulus GO:0048545; response to steroid hormone 6.800E-05 3.004E-03 ALPL, BCL2, CA2, CD38, FLT3, NPC1, PTGS2, SRC
BP GO:0065007; biological regulation GO:0045124; regulation of bone resorption 7.155E-05 3.141E-03 CA2, CD38, SRC, SYK
MF GO:0005488; binding GO:0002039; p53 binding 7.461E-05 3.262E-03 GSK3B, HIF1A, HTT, NUAK1, TP53
BP GO:0032502; developmental process GO:0060065; uterus development 8.097E-05 3.484E-03 CYP19A1, ESR1, SRC
BP GO:0009987; cellular process GO:0031334; positive regulation of protein complex assembly 8.214E-05 3.528E-03 ALOX15, ESR1, GSK3B, MAPT, MET, MMP3, SRC, TP53
CC GO:0016020; membrane GO:0045121; membrane raft 9.036E-05 3.850E-03 APP, BACE1, INSR, KDR, NPC1, PTGS2, SLC6A2, SRC, STAT6
BP Unclassified; GO:0044243; multicellular organismal catabolic process 9.123E-05 3.880E-03 MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0009987; cellular process GO:1903201; regulation of oxidative stress-induced cell death 9.736E-05 4.109E-03 AKT1, HIF1A, MET, MMP3, TP53
BP GO:0050896; response to stimulus GO:0071222; cellular response to lipopolysaccharide 9.933E-05 4.167E-03 AXL, BCR, MAPK14, NFKB1, NR1H4, SRC
MF GO:0003824; catalytic activity GO:0016616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9.933E-05 4.167E-03 AKR1B1, AKR1B10, HPGD, HSD17B10, HSD17B2, PGD
BP GO:0022610; biological adhesion GO:0033628; regulation of cell adhesion mediated by integrin 1.089E-04 4.500E-03 CYP1B1, PIK3CG, PTK2, SYK
BP GO:0032502; developmental process GO:0031100; animal organ regeneration 1.106E-04 4.546E-03 AXL, CDK1, CSNK2A1, FLT3, PKM
BP GO:0009987; cellular process GO:0050714; positive regulation of protein secretion 1.111E-04 4.547E-03 ACHE, CD38, HIF1A, MAPK14, NR1H4, PLA2G1B, SRC, SYK
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.144E-04 4.562E-03 CA2, CA7
BP GO:0019740; nitrogen utilization GO:0006808; regulation of nitrogen utilization 1.144E-04 4.562E-03 BCL2, NR1H4
BP GO:0009987; cellular process GO:0038183; bile acid signaling pathway 1.144E-04 4.562E-03 GPBAR1, NR1H4
MF GO:0003824; catalytic activity GO:0050473; arachidonate 15-lipoxygenase activity 1.144E-04 4.562E-03 ALOX15, PTGS2
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.144E-04 4.562E-03 CYP1A1, CYP3A4
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.144E-04 4.562E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.144E-04 4.562E-03 ALOX12, ALOX15
MF GO:0060089; molecular transducer activity GO:0038181; bile acid receptor activity 1.144E-04 4.562E-03 GPBAR1, NR1H4
BP GO:0009987; cellular process GO:1901796; regulation of signal transduction by p53 class mediator 1.159E-04 4.614E-03 AKT1, AURKB, CSNK2A1, L3MBTL1, MAPK14, NUAK1, TP53
BP GO:0008152; metabolic process GO:1901575; organic substance catabolic process 1.192E-04 4.720E-03 ACHE, AKR1B10, AKT1, ALDH1A1, APOBEC3G, AURKB, BACE1, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, GAA, GSK3B, HSD17B10, MAOA, PKM, PLA2G1B, PYGL, TP53, USP2, XDH
MF GO:0005488; binding GO:0042803; protein homodimerization activity 1.223E-04 4.806E-03 ABCG2, ACHE, AKT1, APOBEC3G, BCL2, CAMK2B, FLT3, HPGD, MAPT, NFKB1, NQO2, PTGS2, PYGL, TOP2A, XDH
BP GO:0009987; cellular process GO:0000226; microtubule cytoskeleton organization 1.351E-04 5.273E-03 AURKB, CDK1, HDAC3, HTT, LMNA, MAPT, NEK2, NEK6, PTK2
BP GO:0009987; cellular process GO:0060326; cell chemotaxis 1.476E-04 5.660E-03 ABCC1, CXCR1, PIK3CA, PIK3CB, PIK3CG, PLA2G1B, SYK
MF GO:0003824; catalytic activity GO:0008392; arachidonic acid epoxygenase activity 1.492E-04 5.665E-03 CYP2C19, CYP2C8, CYP2C9
MF GO:0003824; catalytic activity GO:0035173; histone kinase activity 1.492E-04 5.665E-03 AURKB, CDK1, PKN1
BP GO:0009987; cellular process GO:2000106; regulation of leukocyte apoptotic process 1.585E-04 5.928E-03 AURKB, AXL, HIF1A, PIK3CB, TP53
MF GO:0003824; catalytic activity GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors 1.587E-04 5.928E-03 AKR1B1, AKR1B10, ALDH1A1, XDH
BP GO:0032501; multicellular organismal process GO:0051241; negative regulation of multicellular organismal process 1.609E-04 5.964E-03 ALOX12, APP, AXL, BCL2, BCR, CD38, GPR35, GSK3B, HIF1A, LMNA, NFKB1, NR1H4, PIK3CG, PIK3R1, PTGS2, PTK2, PTPN2, XDH
BP GO:0009987; cellular process GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis 1.615E-04 5.964E-03 PIK3CA, PIK3CB, PIK3R1, PTK2, SRC, SYK
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 1.632E-04 6.014E-03 ABCC1, CA2, CA4, CA9, HPGD, SLCO1B1, SLCO1B3
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 1.734E-04 6.344E-03 AKT1, LMNA, MMP9, TP53
BP GO:0008152; metabolic process GO:0045862; positive regulation of proteolysis 1.797E-04 6.533E-03 AKT1, APP, CDK1, DAPK1, GSK3B, MAPK14, MAPT, PTK2, SRC, XDH
CC GO:0016020; membrane GO:0005789; endoplasmic reticulum membrane 1.853E-04 6.703E-03 BCL2, CAMK2B, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, HSD17B2, NOX4, PTGS1, PTGS2, RAB9A
BP Unclassified; GO:0042993; positive regulation of transcription factor import into nucleus 1.890E-04 6.801E-03 APP, HDAC3, PIK3R1, PTGS2
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 1.984E-04 7.047E-03 HIF1A, MMP13, MMP2, MMP3, MMP9
MF GO:0005488; binding GO:0005496; steroid binding 1.984E-04 7.047E-03 CYP3A4, ESR1, ESR2, NPC1, NR1H4
BP GO:0002376; immune system process GO:0002521; leukocyte differentiation 2.278E-04 7.911E-03 AXL, BCL2, FLT3, GLO1, MAPK14, MMP9, PIK3R1, PTPN2
BP GO:0009987; cellular process GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway 2.278E-04 7.911E-03 PTPN1, PTPN2
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 2.278E-04 7.911E-03 CYP1A1, CYP1A2
MF GO:0005488; binding GO:0034056; estrogen response element binding 2.278E-04 7.911E-03 ESR1, ESR2
MF GO:0005488; binding GO:0051425; PTB domain binding 2.278E-04 7.911E-03 APP, INSR
BP GO:0050896; response to stimulus GO:0071320; cellular response to cAMP 2.616E-04 8.901E-03 APEX1, APP, NOX4, PIK3CG
MF GO:0005215; transporter activity GO:0005319; lipid transporter activity 2.813E-04 9.481E-03 ABCC1, ABCG2, HTT, NPC1, SLCO1B1, SLCO1B3
BP GO:0050896; response to stimulus GO:0055093; response to hyperoxia 2.866E-04 9.616E-03 CYP1A1, POLB, TP53
MF GO:0005488; binding GO:0003682; chromatin binding 2.919E-04 9.763E-03 APEX1, CDK1, ESR1, GMNN, HDAC3, L3MBTL1, MPO, NFKB1, PKN1, TOP2A, TP53
BP GO:0065007; biological regulation GO:0043393; regulation of protein binding 2.959E-04 9.867E-03 APP, AURKB, BCL2, GSK3B, MET, MMP9, SRC
BP GO:0051179; localization GO:0015701; bicarbonate transport 3.357E-17 3.322E-14 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.756E-16 1.416E-13 CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 7.466E-24 1.404E-21 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 4.976E-15 4.678E-13 CAMK2B; SRC; MMP2; PIK3R1; PIK3CB; MAPK14; HIF1A; ESR1; MMP9; PTK2; PIK3CG; IGF1R; PIK3CA; KDR; AKT1; TP53; MET
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 5.050E-13 3.165E-11 GSK3B; PIK3CA; SRC; AKT1; PIK3CB; PIK3R1; MAPK14; ESR1; NFKB1; ESR2; PIK3CG
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 2.765E-12 1.082E-10 GSK3B; FLT3; DAPK1; MMP2; PIK3CB; PIK3R1; PTGS2; HIF1A; MMP9; NFKB1; PIK3CG; PTK2; IGF1R; BCR; PIK3CA; BCL2; AKT1; MET; TP53
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 2.878E-12 1.082E-10 PIK3CA; SRC; KDR; AKT1; PIK3CB; PIK3R1; MAPK14; PTGS2; PTK2; PIK3CG
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 1.914E-11 5.140E-10 GSK3B; SYK; CSNK2A1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG; PIK3CA; BCL2; CDK1; AKT1; CD38; TP53
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 7.681E-12 2.407E-10 PKM; PIK3CA; FLT3; AKT1; PIK3CB; PIK3R1; TP53; MET; HIF1A; PIK3CG
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 2.853E-11 6.704E-10 CAMK2B; PIK3CA; INSR; BCL2; AKT1; PIK3R1; PIK3CB; HIF1A; NFKB1; PIK3CG; IGF1R
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 2.242E-10 3.011E-09 GSK3B; SYK; INSR; PIK3R1; PIK3CB; PTK2; NFKB1; PIK3CG; IGF1R; PIK3CA; KDR; BCL2; AKT1; PKN1; TP53; MET
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 9.971E-11 2.083E-09 PIK3CA; BCL2; AKT1; PIK3CB; PIK3R1; PTGS2; TP53; NFKB1; PTK2; PIK3CG
hsa05215 Prostate cancer_Homo sapiens_hsa05215 1.410E-10 2.205E-09 GSK3B; PIK3CA; BCL2; AKT1; PIK3CB; PIK3R1; TP53; NFKB1; PIK3CG; IGF1R
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 1.155E-10 2.169E-09 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS2; PTGS1
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 1.269E-10 2.169E-09 GSK3B; HDAC3; PIK3CA; SRC; AKT1; PIK3R1; PIK3CB; TP53; ESR1; HIF1A; PIK3CG
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 1.524E-10 2.205E-09 CAMK2B; GSK3B; PIK3CA; BCL2; AKT1; PIK3R1; PIK3CB; MAPK14; TP53; NFKB1; PIK3CG
hsa04510 Focal adhesion_Homo sapiens_hsa04510 2.626E-10 3.291E-09 GSK3B; SRC; PIK3R1; PIK3CB; PTK2; PIK3CG; MYLK; IGF1R; PIK3CA; KDR; BCL2; AKT1; MET
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 5.018E-10 5.241E-09 PIK3CA; MMP2; PIM1; BCL2; AKT1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 4.110E-10 4.545E-09 PIK3CA; SRC; MMP2; AKT1; PIK3R1; PIK3CB; ESR1; MMP9; ESR2; PIK3CG
hsa05161 Hepatitis B_Homo sapiens_hsa05161 1.261E-09 1.078E-08 PIK3CA; SRC; BCL2; AKT1; STAT6; PIK3R1; PIK3CB; TP53; MMP9; NFKB1; PIK3CG
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 1.171E-09 1.048E-08 PIK3CA; MMP3; AKT1; PIK3R1; PIK3CB; MAPK14; PTGS2; MMP9; NFKB1; PIK3CG
hsa04931 Insulin resistance_Homo sapiens_hsa04931 1.070E-09 1.006E-08 PTPN1; GSK3B; PIK3CA; INSR; AKT1; PIK3R1; PIK3CB; PYGL; NFKB1; PIK3CG
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 1.399E-09 1.143E-08 CYP2C9; APP; CYP2C8; MAOA; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS2; PTGS1
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 5.770E-10 5.709E-09 ALOX5; INSR; HSD17B2; CYP1A1; CYP1B1; PTGS2; CYP19A1; IGF1R
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 3.661E-09 2.294E-08 PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; PTGS2; CYP2C19; CYP3A4; CYP19A1; HSD17B10; PTGS1; ALOX5; HSD17B2; CD38; XDH; GAA; PGD; CYP2C9; CYP2C8; PKM; AKR1B10; CYP1A2; ALDH1A1; CYP1A1; ALPL; ALPI
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 3.898E-09 2.364E-08 POLB; PKM; HDAC3; SYK; PIK3CA; SRC; CDK1; PIK3R1; PIK3CB; TP53; NFKB1; PIK3CG
hsa04611 Platelet activation_Homo sapiens_hsa04611 3.240E-09 2.175E-08 PIK3CA; SYK; SRC; AKT1; PIK3R1; PIK3CB; MAPK14; PIK3CG; MYLK; PTGS1
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 2.577E-09 1.863E-08 CAMK2B; GSK3B; PIK3CA; SRC; AKT1; PIK3CB; PIK3R1; PTK2; PIK3CG
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 2.756E-09 1.919E-08 ABCC1; PIK3CA; BCL2; AKT1; PIK3R1; PIK3CB; MAPK14; TP53; NFKB1; PIK3CG
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 1.482E-09 1.161E-08 PIK3CA; INSR; AKT1; PIK3CB; PIK3R1; PTGS2; PIK3CG; PTGS1
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 1.715E-09 1.290E-08 PIK3CA; FLT3; PIM1; AKT1; PIK3CB; PIK3R1; NFKB1; PIK3CG
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 7.482E-09 4.137E-08 PIK3CA; CDK1; AKT1; PIK3R1; PIK3CB; MAPK14; PIK3CG; CDC25B; IGF1R
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 5.159E-09 2.939E-08 PIK3CA; INSR; AKT1; PIK3CB; PIK3R1; TP53; NFKB1; PIK3CG; IGF1R
hsa05162 Measles_Homo sapiens_hsa05162 9.314E-09 5.003E-08 GSK3B; PIK3CA; CSNK2A1; AKT1; RAB9A; PIK3R1; PIK3CB; TP53; NFKB1; PIK3CG
hsa05214 Glioma_Homo sapiens_hsa05214 5.033E-09 2.939E-08 CAMK2B; PIK3CA; AKT1; PIK3CB; PIK3R1; TP53; PIK3CG; IGF1R
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 3.422E-09 2.219E-08 GSK3B; PIK3CA; BCL2; AKT1; PIK3CB; PIK3R1; TP53; PIK3CG
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 3.282E-10 3.856E-09 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa04630 Jak-STAT signaling pathway_Homo sapiens_hsa04630 3.920E-08 1.755E-07 PIK3CA; THPO; PIM1; BCL2; AKT1; STAT6; PIK3R1; PIK3CB; PTPN2; PIK3CG
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 5.901E-08 2.521E-07 PIK3CA; SRC; INSR; KDR; AKT1; PIK3R1; PIK3CB; MAPK14; MET; PIK3CG; IGF1R
hsa05218 Melanoma_Homo sapiens_hsa05218 1.030E-08 5.377E-08 PIK3CA; AKT1; PIK3CB; PIK3R1; TP53; MET; PIK3CG; IGF1R
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 3.846E-08 1.755E-07 PIK3CA; ALOX5; BCL2; AKT1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 1.288E-08 6.372E-08 BCR; PIK3CA; AKT1; PIK3CB; PIK3R1; TP53; NFKB1; PIK3CG
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 1.288E-08 6.372E-08 GSK3B; PIK3CA; SYK; AKT1; PIK3CB; PIK3R1; NFKB1; PIK3CG
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 1.240E-07 4.960E-07 PIK3CA; PLA2G1B; INSR; KDR; AKT1; PIK3R1; PIK3CB; MET; NFKB1; PIK3CG; IGF1R
hsa05160 Hepatitis C_Homo sapiens_hsa05160 1.086E-07 4.489E-07 GSK3B; PIK3CA; AKT1; PIK3R1; PIK3CB; MAPK14; TP53; NFKB1; PIK3CG
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 1.331E-07 5.026E-07 CAMK2B; PIK3CA; SRC; ALOX12; PIK3R1; PIK3CB; MAPK14; PIK3CG
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 1.340E-07 5.026E-07 HPGD; FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa04210 Apoptosis_Homo sapiens_hsa04210 1.687E-07 5.874E-07 PIK3CA; LMNA; BCL2; AKT1; PIK3R1; PIK3CB; TP53; NFKB1; PIK3CG
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 3.265E-08 1.535E-07 CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19; PTGS2
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 1.914E-07 6.542E-07 GSK3B; PIK3CA; CXCR1; SRC; AKT1; PIK3R1; PIK3CB; NFKB1; PTK2; PIK3CG
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 1.587E-07 5.736E-07 PTPN1; GSK3B; PIK3CA; INSR; AKT1; PIK3R1; PIK3CB; PYGL; PIK3CG
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 3.501E-07 1.155E-06 CAMK2B; ACHE; PIK3CA; BCL2; AKT1; PIK3R1; PIK3CB; PIK3CG
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 2.510E-08 1.210E-07 GSK3B; PIK3CA; AKT1; PIK3CB; PIK3R1; TP53; PIK3CG
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 4.721E-07 1.479E-06 CAMK2B; PIK3CA; SRC; CD38; PIK3R1; PIK3CB; PTGS2; PIK3CG; MYLK
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 2.115E-07 7.100E-07 GSK3B; PIK3CA; AKT1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 4.266E-08 1.865E-07 ALK; PIK3CA; AKT1; PIK3CB; PIK3R1; TP53; PIK3CG
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 1.098E-07 4.489E-07 PIK3CA; INSR; AKT1; PIK3CB; PIK3R1; PIK3CG; IGF1R
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 1.780E-06 5.070E-06 ABCC1; PIK3CA; PIM1; BCL2; CYP1B1; PTGS2; TP53; MMP9; MET; NFKB1; CDC25B
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 1.315E-06 3.924E-06 PIK3CA; SYK; AKT1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 1.680E-07 5.874E-07 PIK3CA; SYK; AKT1; PIK3CB; PIK3R1; MAPK14; PIK3CG
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 1.392E-06 4.090E-06 PIK3CA; INSR; AKT1; PIK3R1; PIK3CB; MAPK14; PIK3CG; IGF1R
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 5.601E-07 1.726E-06 PIK3CA; MMP2; PIK3R1; PIK3CB; MAPK14; MMP9; PTK2; PIK3CG
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 1.363E-07 5.026E-07 PIK3CA; AKT1; PIK3CB; PIK3R1; MET; HIF1A; PIK3CG
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 1.363E-07 5.026E-07 PIK3CA; AKT1; PIK3CB; PIK3R1; TP53; NFKB1; PIK3CG
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 2.531E-06 6.935E-06 PIK3CA; SYK; CXCR1; INSR; AKT1; PIK3R1; PIK3CB; PIK3CG
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 2.279E-06 6.395E-06 GSK3B; PIK3CA; AKT1; PIK3R1; PIK3CB; MAPK14; PIK3CG; IGF1R
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 3.106E-06 8.224E-06 CAMK2B; PIK3CA; BCL2; AKT1; PIK3R1; PIK3CB; MAPK14; PIK3CG
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 3.607E-06 9.081E-06 GSK3B; PIK3CA; INSR; AKT1; PIK3R1; PIK3CB; NFKB1; PIK3CG
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 4.359E-07 1.389E-06 PIK3CA; SRC; PIK3CB; PIK3R1; MET; PTK2; PIK3CG
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 3.082E-06 8.224E-06 PIK3CA; AKT1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 3.501E-06 9.016E-06 PIK3CA; AKT1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 2.589E-05 5.864E-05 POLB; GSK3B; PIK3CA; AKT1; PIK3R1; PIK3CB; TP53; NFKB1; PIK3CG
hsa05164 Influenza A_Homo sapiens_hsa05164 1.069E-05 2.482E-05 GSK3B; PIK3CA; AKT1; PIK3R1; PIK3CB; MAPK14; NFKB1; PIK3CG
hsa04152 AMPK signaling pathway_Homo sapiens_hsa04152 9.894E-06 2.325E-05 PIK3CA; INSR; AKT1; PIK3R1; PIK3CB; PIK3CG; IGF1R
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 6.729E-05 1.454E-04 PIK3CA; INSR; AKT1; PIK3R1; PIK3CB; PIK3CG; MYLK
hsa04810 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 3.117E-04 6.233E-04 PIK3CA; SRC; PIK3R1; PIK3CB; PTK2; PIK3CG; MYLK
hsa05152 Tuberculosis_Homo sapiens_hsa05152 1.004E-04 2.098E-04 CAMK2B; SYK; SRC; BCL2; AKT1; MAPK14; NFKB1
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 4.416E-03 7.982E-03 AKT1; MAPT; MAPK14; TP53; NFKB1; CDC25B
hsa04144 Endocytosis_Homo sapiens_hsa04144 2.005E-02 3.202E-02 CXCR1; SRC; KDR; MET; IGF1R
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 2.002E-04 4.091E-04 CAMK2B; PIK3CA; AKT1; PIK3R1; PIK3CB; NFKB1; PIK3CG
hsa04060 Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 2.188E-02 3.457E-02 CXCR1; THPO; FLT3; KDR; MET
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 3.454E-03 6.367E-03 BACE1; APP; GSK3B; MAPT; HSD17B10
hsa04650 Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 1.333E-03 2.583E-03 PIK3CA; SYK; PIK3R1; PIK3CB; PIK3CG
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 2.541E-02 3.948E-02 CSNK2A1; CDK1; TP53; NFKB1
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 1.061E-02 1.796E-02 CAMK2B; GSK3B; CSNK2A1; TP53
hsa04110 Cell cycle_Homo sapiens_hsa04110 6.652E-03 1.191E-02 GSK3B; CDK1; TP53; CDC25B
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 3.277E-05 7.248E-05 PIK3CA; AKT1; PIK3R1; PIK3CB; HIF1A; PIK3CG
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 1.283E-04 2.652E-04 CAMK2B; GSK3B; MAOA; AKT1; MAPK14; DRD4
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 2.049E-05 4.698E-05 PIK3CA; SYK; AKT1; PIK3CB; PIK3R1; PIK3CG
hsa05146 Amoebiasis_Homo sapiens_hsa05146 3.097E-05 6.932E-05 PIK3CA; PIK3R1; PIK3CB; NFKB1; PTK2; PIK3CG
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 3.216E-03 5.986E-03 CAMK2B; PKM; AKT1; PYGL
hsa04070 Phosphatidylinositol signaling system_Homo sapiens_hsa04070 2.885E-03 5.478E-03 PIK3CA; PIK3R1; PIK3CB; PIK3CG
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 2.204E-03 4.228E-03 CAMK2B; SRC; MMP2; MAPK14
hsa04972 Pancreatic secretion_Homo sapiens_hsa04972 2.010E-02 3.202E-02 CA2; PLA2G1B; CD38
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 1.581E-06 4.573E-06 PIK3CA; AKT1; PIK3CB; PIK3R1; HIF1A; PIK3CG
hsa04640 Hematopoietic cell lineage_Homo sapiens_hsa04640 1.597E-02 2.634E-02 THPO; FLT3; CD38
hsa05132 Salmonella infection_Homo sapiens_hsa05132 1.503E-02 2.522E-02 PKN1; MAPK14; NFKB1
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 2.439E-04 4.931E-04 SYK; CSNK2A1; BCL2; PTGS2; NFKB1
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 9.657E-03 1.666E-02 MAPK14; PTGS2; NFKB1
hsa04971 Gastric acid secretion_Homo sapiens_hsa04971 1.002E-02 1.713E-02 CAMK2B; CA2; MYLK
hsa00562 Inositol phosphate metabolism_Homo sapiens_hsa00562 8.952E-03 1.558E-02 PIK3CA; PIK3CB; PIK3CG
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 2.545E-06 6.935E-06 CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa04520 Adherens junction_Homo sapiens_hsa04520 5.464E-06 1.317E-05 PTPN1; CSNK2A1; SRC; INSR; MET; IGF1R
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 1.291E-06 3.914E-06 CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa04976 Bile secretion_Homo sapiens_hsa04976 4.286E-06 1.060E-05 SLCO1B1; CA2; SLCO1B3; NR1H4; CYP3A4; ABCG2
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 3.623E-06 9.081E-06 CYP2C9; CYP2C8; MAOA; CYP1A2; CYP3A4; CYP2C19
hsa05131 Shigellosis_Homo sapiens_hsa05131 7.021E-03 1.245E-02 SRC; MAPK14; NFKB1
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 7.755E-05 1.657E-04 CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04930 Type II diabetes mellitus_Homo sapiens_hsa04930 4.109E-07 1.332E-06 PKM; PIK3CA; INSR; PIK3CB; PIK3R1; PIK3CG
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 5.512E-05 1.205E-04 CXCR1; SRC; MAPK14; MET; NFKB1
hsa00983 Drug metabolism - other enzymes_Homo sapiens_hsa00983 3.112E-02 4.757E-02 CYP3A4; XDH
hsa05014 Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 3.557E-03 6.492E-03 BCL2; MAPK14; TP53
hsa02010 ABC transporters_Homo sapiens_hsa02010 2.867E-02 4.417E-02 ABCC1; ABCG2
hsa00620 Pyruvate metabolism_Homo sapiens_hsa00620 2.400E-02 3.761E-02 PKM; GLO1
hsa00040 Pentose and glucuronate interconversions_Homo sapiens_hsa00040 1.969E-02 3.191E-02 AKR1B10; AKR1B1
hsa04973 Carbohydrate digestion and absorption_Homo sapiens_hsa04973 7.211E-06 1.716E-05 PIK3CA; AKT1; PIK3CB; PIK3R1; PIK3CG
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 1.575E-02 2.620E-02 AKR1B10; AKR1B1
hsa03410 Base excision repair_Homo sapiens_hsa03410 1.670E-02 2.730E-02 POLB; APEX1
hsa04960 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 3.497E-06 9.016E-06 PIK3CA; INSR; PIK3CB; PIK3R1; PIK3CG
hsa05219 Bladder cancer_Homo sapiens_hsa05219 4.509E-06 1.101E-05 DAPK1; SRC; MMP2; MMP9; TP53
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 7.598E-04 1.488E-03 AKR1B10; GAA; AKR1B1
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 9.532E-05 2.013E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 8.318E-03 1.462E-02 CA2; CA4
hsa00790 Folate biosynthesis_Homo sapiens_hsa00790 3.099E-03 5.826E-03 ALPL; ALPI
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 3.528E-04 6.982E-04 CYP1A2; XDH
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE
E00-E89: Endocrine, nutritional and metabolic diseases Dietary shortage E40-E46 PTGS1
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases Amyloidosis E85 APP
S00-T88: Injury, poisoning and certain other consequences of external causes Postoperative inflammation T81 PTGS1
N00-N99: Diseases of the genitourinary system Post-menopausal vaginal atrophy N95.2 ESR1
NA: NA Postmenopausal disorder NA ESR1
C00-D49: Neoplasms Prostate cancer C61 PIK3CG; FLT3; BCL2; ESR1
I00-I99: Diseases of the circulatory system Acute coronary syndrome I74 MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1; GSK3B; PTPN1; INSR
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
C00-D49: Neoplasms Thyroid cancer C73 KDR
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 ALOX5; SYK; PIK3CB
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
C00-D49: Neoplasms Melanoma C43 KDR; KDR
NA: NA Menopausal disorder NA ESR1
K00-K95: Diseases of the digestive system Colon polyps K63.5 PTGS2
C00-D49: Neoplasms Colorectal cancer C18-C21 FLT3; PTGS1; IGF1R; MMP9; TP53; KDR
NA: NA Colour dead tissues NA PTPN1
NA: NA Acute respiratory distress syndrome NA MAPK14
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA; SLC6A2
H00-H59: Diseases of the eye and adnexa Corneal ulcers H16.0 MMP3
I00-I99: Diseases of the circulatory system Coronary artery disease I20-I25 MAPK14; MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Female hypogonadism E23, E28 ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue Atrophy M62.571 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 SYK; INSR; ESR1
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 PIK3CG; CYP2C9
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
C00-D49: Neoplasms AML NA FLT3; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 PTPN1; SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE; APP
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR
C00-D49: Neoplasms Gastric cancer C16 KDR; KDR
N00-N99: Diseases of the genitourinary system Female infertility N97.0 ESR1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5; RAB9A
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthralgia M25.5 ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B; ABCC1; ALOX5; PIK3CG; PTGS2; PTGS2; MAPK14
J00-J99: Diseases of the respiratory system Asthma J45 PLA2G1B; ALOX5; ALOX5; SYK; SYK; PTGS2
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR
C00-D49: Neoplasms Metastatic breast cancer C50 PIK3CG; KDR
C00-D49: Neoplasms Mesothelioma C45 PTK2
N00-N99: Diseases of the genitourinary system Menorrhagia N92.0 ESR1
N00-N99: Diseases of the genitourinary system Menopause symptoms N95.0 ESR1; ESR1
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
H00-H59: Diseases of the eye and adnexa Eye disorders H00-H59 ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Fatigue R53 SLC6A2
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1; ESR1; APP
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA; PTGS1; PTGS2; PTGS2
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT; ACHE
C00-D49: Neoplasms Neuroendocrine cancer C7A SLC6A2
C00-D49: Neoplasms Neuroblastoma C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7 SLC6A2
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1; PTGS1
G00-G99: Diseases of the nervous system G00-G99 Mild to moderate alzheimer disease G30 APP
NA: NA Joint and muscular pain NA PTGS2
I00-I99: Diseases of the circulatory system Ischemic stroke I61-I63 MMP3
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hypogonadism E23.0, E28.3, E29.1 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Hypoglycemia E16.0-E16.2 INSR
E00-E89: Endocrine, nutritional and metabolic diseases Estrogen deficiency E28.39 ESR1
C00-D49: Neoplasms Non-hodgkin's lymphoma C85 SYK; PIK3CG; PIK3CG
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 INSR
C00-D49: Neoplasms Non-small-cell lung cancer NA KDR
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; AXL; PTGS2; IGF1R; IGF1R; KDR
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MPO; PLA2G1B; ALOX5; MMP13; SYK; PIK3CG; PTGS1; PTGS2; MAPK14
NA: NA Inflammatory diseases NA MAPK14
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5; PTGS2
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 PTGS1; PTGS2; MAPK14
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2
N00-N99: Diseases of the genitourinary system Infertility N97.0 ESR1
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Female sexual dysfunction F52 ESR1
NA: NA Enthesopathy NA PIK3CG
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 DRD4
C00-D49: Neoplasms Glioblastoma NA FLT3
NA: NA GIST NA FLT3
NA: NA Gonorrheal vaginitis NA ESR1
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; GSK3B; MAPT; ACHE; ACHE; ACHE; PTGS2; INSR; APP
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 PLA2G1B; ALOX5; SYK
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 PLA2G1B
C00-D49: Neoplasms Refractory renal cell carcinoma C64 PKM
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Osteopetrosis Q78.2 ESR1
C00-D49: Neoplasms Myeloid leukemia C92 FLT3
I00-I99: Diseases of the circulatory system Atherosclerosis I70 ALOX5
C00-D49: Neoplasms Myelodysplastic syndrome D46 KDR
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE
C00-D49: Neoplasms Acute myeloid leukemia C92.0 FLT3; FLT3; AURKB; TP53; TP53
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET
C00-D49: Neoplasms Lung cancer C33-C34 MMP2
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; PIK3CG; PIK3CG; CA9; INSR; HIF1A; BCL2
H00-H59: Diseases of the eye and adnexa Macular degeneration H35.3 APP
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
C00-D49: Neoplasms Endometrial cancer C54.1 PIK3CG; PIK3CG
NA: NA Edema NA CA2
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
H00-H59: Diseases of the eye and adnexa Age related macular degeneration H35.3 APP
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 MMP2; PTGS1; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 GAA
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 PIK3CG; MMP3
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3; BCL2; ESR1
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR
NA: NA Early satiation associated with functional dyspepsia NA ACHE
N00-N99: Diseases of the genitourinary system Dyspareunia N94.1 ESR1
N00-N99: Diseases of the genitourinary system Dysmenorrhea N94.4-N94.6 PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; ESR1
A00-B99: Certain infectious and parasitic diseases Anthelmintic B89 ALPL
NA: NA Angioedema NA PIK3CG
M00-M99: Diseases of the musculoskeletal system and connective tissue Ankylosing spondylitis M08.1, M45 PTGS2
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 ACHE; CA4; CA2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chronic pain R52.1-R52.2, G89 PTGS2
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MPO; ALOX5; MAPK14
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 SYK; BCL2
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 SRC
NA: NA Geographic retinal atrophy NA APP
C00-D49: Neoplasms Osteosarcoma C40-C41 GSK3B; SRC
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 SRC; ESR1
C00-D49: Neoplasms Ovarian cancer C56 MMP2; KDR; KDR; KDR; KDR
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET; PIK3CG; PIK3CG
NA: NA Hematopoietic stem cell transplantation NA FLT3
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1; PIK3CG
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; KDR
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
G00-G99: Diseases of the nervous system G00-G99 Amyotrophic lateral sclerosis G12.2 BCL2
N00-N99: Diseases of the genitourinary system Atrophic vaginitis N95.2 ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Attention deficit hyperactivity disorder F90 SLC6A2; SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT; ACHE
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
C00-D49: Neoplasms CLL NA FLT3
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; FLT3; MMP2; PTGS2; KDR
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 PKM; MMP13; ACHE; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; IGF1R; INSR; CDK1; SLC6A2; ESR1
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 MPO; MAOA; ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 CAMK2B; AKR1B1; PLA2G1B; ALOX5; SYK; MMP3; PTGS2; PTGS2; PTGS2; PTGS2; MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Hyperglycaemia in type 2 diabetes E11, R73.9 INSR
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2
C00-D49: Neoplasms Hormone refractory prostate cancer C61 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R; ESR1; ESR1
H00-H59: Diseases of the eye and adnexa Diabetic retinopathy H36, E10.3, E11.3, E13.3 MAPK14
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
G00-G99: Diseases of the nervous system G00-G99 Diagnostic imaging G30, I73.9 APP
J00-J99: Diseases of the respiratory system Acute lung injury J80 MAPK14
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3
N00-N99: Diseases of the genitourinary system Irregularities N92.6 ESR1
I00-I99: Diseases of the circulatory system Cerebral amyloid angiopathy I68.0 APP
C00-D49: Neoplasms Ocular cancer C69 APEX1
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 CA4; CA4
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 GPBAR1
E00-E89: Endocrine, nutritional and metabolic diseases Hypercholesterolemia E78 INSR
Z00-Z99: Factors influencing health status and contact with health services Hormone replacement therapy Z79.890 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Hunter syndrome E76.1 INSR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA; SLC6A2; SLC6A2; SLC6A2; SLC6A2
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ALOX5; PTGS1
C00-D49: Neoplasms Metastasis C00-C97 AXL
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 CA1; ACHE
Z00-Z99: Factors influencing health status and contact with health services Oral contraceptive Z30 ESR1
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 ALOX5; MMP13; MMP3; MMP2; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2
C00-D49: Neoplasms Diffuse large B-cell lymphoma C83.3 PIK3CG
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 INSR; ESR1
G00-G99: Diseases of the nervous system G00-G99 Multiple scierosis G35 MPO; ESR1; ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue Knee osteoarthritis M15-M19, M47 PTGS2
K00-K95: Diseases of the digestive system Crohn's disease K50 INSR
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
C00-D49: Neoplasms Advanced melanoma C43 BCL2
C00-D49: Neoplasms Advanced prostate cancer C61 ESR1
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 ALOX5
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
C00-D49: Neoplasms Cancer C00-C96 AKT1; MET; GSK3B; CSNK2A1; SYK; PIK3CA; PIK3CG; CA1; FLT3; FLT3; CA9; MMP2; NQO2; ACHE; PTGS2; SRC; IGF1R; CD38; HIF1A; CDK1; MAPK14; MMP9; NFKB1; PIM1; CDC25B; PTK2; BCL2; BCL2; TP53; PIK3CB; ESR1; ESR1; KDR; APP
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cancer pain R52, G89 SLC6A2
N00-N99: Diseases of the genitourinary system Endometriosis N80 PTGS2; CYP19A1
Z00-Z99: Factors influencing health status and contact with health services Contraception Z30 ESR1
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Genetic disease Q00-Q99 ALPL
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR
C00-D49: Neoplasms Adrenocortical carcinoma C74.0 ESR1
C00-D49: Neoplasms Advanced breast cancer C50 SRC; CYP19A1
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A PIK3CA; PTK2; TP53
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 PIK3CG; KDR
C00-D49: Neoplasms Glioblastoma multiforme C71 SRC
C00-D49: Neoplasms Gliosarcoma NA FLT3
C00-D49: Neoplasms Glioma C71 PIK3CG; KDR; APP
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; CA1; CA1; ACHE
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; ABCC1; ABCC1; PTGS2; XDH
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 DRD4
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA1; CA2; MYLK
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
C00-D49: Neoplasms B-cell lymphoma C85.1 SYK
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Bipolar disorder F31, F40-F42 SLC6A2
C00-D49: Neoplasms Bladder cancer C67 CYP19A1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CAMK2B; MAOA; ACHE; SLC6A2; CYP3A4
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
C00-D49: Neoplasms Colon cancer C50 ALPL; FLT3
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 ALOX5; FLT3; MAPK14; BCL2
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 PLA2G1B; ALOX5
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1
C00-D49: Neoplasms Breast cancer C50 PIK3CG; FLT3; FLT3; CA9; NQO2; IGF1R; INSR; CYP19A1; CDK1; BCL2; ESR1; ESR1; KDR; KDR; KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Brain injury S09.90 APP
S00-T88: Injury, poisoning and certain other consequences of external causes Hyperthermia T68 PTGS2
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
I00-I99: Diseases of the circulatory system Heart failure I50 XDH; SLC6A2
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
M00-M99: Diseases of the musculoskeletal system and connective tissue Fibromyalgia M79.7 SLC6A2
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA
C00-D49: Neoplasms Brain cancer C71, D33 SRC; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Type 1/2 diabetes E08-E13 INSR
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 PTPN1; PTPN1; PIK3CG; PIK3CG; PTGS2; INSR; NFKB1; GPBAR1
E00-E89: Endocrine, nutritional and metabolic diseases Type 1 diabetes E10 INSR
A00-B99: Certain infectious and parasitic diseases Trematode infection B66.9 ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
C00-D49: Neoplasms Solid tumours C00-D48 AKT1; MET; PKM; SYK; PIK3CA; PIK3CG; FLT3; CA9; MMP2; SRC; IGF1R; AURKB; HIF1A; MMP9; PTK2; TP53; PIK3CB; KDR; KDR; KDR; TOP2A
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
N00-N99: Diseases of the genitourinary system Female infertility due to anovulation N97.0 ESR1
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
NA: NA Upper abdominal bloating NA ACHE
K00-K95: Diseases of the digestive system Ulcerative colitis K51 PTGS1; MMP9
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE
NA: NA Rheumatold arthritis NA PTGS1; PTGS2; PTGS2; PTGS2; MAPK14
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; TP53; KDR; KDR
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
N00-N99: Diseases of the genitourinary system Vagina disease N76.0 ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 DRD4
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
C00-D49: Neoplasms Multiple myeloma C90 SRC; IGF1R; CD38; BCL2
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Hematological malignancies C81-C86 SYK; SRC; CD38; AURKB; TP53
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 ALOX5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA
M00-M99: Diseases of the musculoskeletal system and connective tissue Moderate to severe rheumatoid arthritis M05-M06 PTGS2
NA: NA Miosis during ocular surgery NA PTGS1
C00-D49: Neoplasms Carcinoma D00-D09 ESR1
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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