CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0007210; serotonin receptor signaling pathway	2.426E-12	1.321E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0060089; molecular transducer activity	GO:0004993; G-protein coupled serotonin receptor activity	2.426E-12	1.321E-08	HTR1A, HTR2B, HTR5A, HTR6, HTR7
MF	GO:0005488; binding	GO:0051378; serotonin binding	4.058E-11	1.262E-07	HTR1A, HTR2B, HTR5A, HTR7
BP	GO:0009987; cellular process	GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway	9.522E-10	1.885E-06	HTR1A, HTR5A, HTR7
BP	Unclassified;	GO:0042310; vasoconstriction	8.614E-07	1.340E-03	HTR1A, HTR2B, HTR7
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	1.106E-06	1.505E-03	DRD1, HTR1A, HTR2B, HTR7
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.262E-06	5.929E-03	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	8.764E-06	7.340E-03	CYP1A2, CYP2D6

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	4.477E-11	1.612E-09	HTR6; HTR7; CYP2D6; HTR1A; HTR2B; HTR5A
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.058E-08	1.904E-07	HTR6; HTR7; HTR1A; HTR2B; DRD1; HTR5A
hsa04020	Calcium signaling pathway_Homo sapiens_hsa04020	6.780E-08	8.137E-07	HTR6; HTR7; HTR2B; DRD1; HTR5A
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	2.578E-04	2.321E-03	HTR6; HTR1A; DRD1
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	7.927E-04	5.136E-03	CYP1A2; ALDH1A1
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	8.928E-04	5.136E-03	CYP2D6; CYP1A2
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	9.986E-04	5.136E-03	CYP2D6; CYP1A2
hsa04540	Gap junction_Homo sapiens_hsa04540	1.447E-03	6.510E-03	HTR2B; DRD1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	3.246E-03	1.298E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	HTR6
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A; HTR1A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR2B; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1; HTR6
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1; HTR1A
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1; HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	HTR2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR6; HTR6; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR7; HTR1A; HTR1A
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
NA: NA	Peripheral sensory neuropathies	NA	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A
NA: NA	Anxiety disorders	NA	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6; HTR2B; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A
I00-I99: Diseases of the circulatory system	Coronary heart disease	I25.1	HTR2B
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HTR7
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	HTR6
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR6; HTR6; HTR6; HTR1A; HTR1A
I00-I99: Diseases of the circulatory system	Congestive heart failure	I50	HTR2B
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1; HTR6; HTR1A
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR7; DRD1; HTR6; HTR1A; HTR1A
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HTR2B; HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychoses	F20-F29	HTR2B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1; HTR1A
NA: NA	Cervical dystonia	NA	HTR1A
I00-I99: Diseases of the circulatory system	Cerebral infarction	I63	HTR2B
NA: NA	Episode	NA	HTR1A
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A
NA: NA	Social phobia	NA	HTR1A
NA: NA	Bulimia nervosa	NA	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A
NA: NA	Schizoaffective disorder	NA	HTR1A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cephalaria leucantha

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases