Plant Name: Sideritis chamaedryfolia
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 6.131E-11 | 1.027E-07 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 2.011E-09 | 2.737E-06 | CYP1A2, CYP2C19, CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 1.574E-08 | 1.653E-05 | CYP1A2, CYP2C19, CYP2C9, CYP3A4, NQO2, PTGS1 |
| BP | GO:0065007; biological regulation | GO:0098771; inorganic ion homeostasis | 2.617E-07 | 2.110E-04 | APP, CA12, CA2, CA7, ESR1, HIF1A, HTT, PIK3CB, TP53 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 3.625E-07 | 2.442E-04 | CYP1A2, CYP2C19, CYP2C9 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 6.633E-07 | 3.801E-04 | CYP1A2, CYP2C9, CYP3A4 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 9.105E-07 | 4.836E-04 | CA2, CA7, HIF1A, HTT, PIK3CB, PTGS2 |
| BP | GO:0065007; biological regulation | GO:0030003; cellular cation homeostasis | 1.306E-06 | 6.772E-04 | APP, CA2, CA7, ESR1, HIF1A, HTT, PIK3CB, TP53 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 1.527E-06 | 7.559E-04 | APP, CYP1A2, CYP2C19, CYP2C9, CYP3A4, ESR1 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.900E-25 | 2.069E-21 | CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
Showing 1 to 10 of 21 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 3.191E-03 | 7.880E-03 | CYP1A2; CYP3A4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 7.230E-03 | 1.508E-02 | CYP1A2 |
| hsa00340 | Histidine metabolism_Homo sapiens_hsa00340 | 3.425E-02 | 4.583E-02 | MAOA |
| hsa00360 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 2.438E-02 | 3.470E-02 | MAOA |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.530E-03 | 4.409E-03 | MAOA; CYP1A2 |
| hsa00562 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 4.742E-03 | 1.083E-02 | PIK3CA; PIK3CB |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.876E-06 | 2.837E-05 | CYP2C9; CYP2C19; PTGS2; PTGS1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 8.255E-08 | 2.497E-06 | CYP2C9; CYP1A2; CYP3A4; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.127E-04 | 7.136E-04 | CYP2C9; CYP1A2; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.753E-32 | 4.541E-30 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13 |
Showing 1 to 10 of 94 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Neuroendocrine cancer | C7A | SLC6A2 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | PTGS2 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; CA9 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; ESR1; ESR1; NQO2 |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | ESR1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | PTGS2; HIF1A; TP53; PIK3CA; PIK3CB; CA1; CA9; ESR1; ESR1; NQO2; APP |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; TP53; PIK3CA; PIK3CB; CA9 |
Showing 1 to 10 of 123 entries