Plant Name: Phebalium gracile
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CXCR1; NPSR1; | |
| DRD4; | |
| RECQL; PLA2G1B; PIK3R1; GLO1; HPGD; MPO; AKR1B1; HSD17B2; ALOX12; ALOX15; NOX4; ALDH1A1; HSD17B10; PYGL; POLB; | |
| PKN1; DAPK1; AKT1; ALK; CAMK2B; MET; FLT3; NEK6; CDK1; PIM1; AXL; IGF1R; NUAK1; NEK2; SRC; KDR; GSK3B; PTK2; AURKB; CSNK2A1; | |
| CA2; CA12; CA1; CA9; CA13; CA3; CA14; CA7; CA5A; CA4; CA6; | |
| KDM4E; | |
| MAOA; ALOX5; XDH; | |
| BACE1; | |
| MMP13; MMP9; MMP3; MMP2; | |
| CASP1; CASP7; | |
| HIF1A; TP53; NFKB1; STAT6; | |
| ABCG2; ABCC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
Showing 1 to 10 of 72 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 3.663E-08 | 7.820E-06 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 9.845E-08 | 1.864E-05 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 1.799E-07 | 3.168E-05 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, NEK6, PKN1, SRC |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 3.122E-07 | 5.073E-05 | ALOX12, ALOX15, ALOX5, HPGD |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 4.508E-07 | 7.011E-05 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, PKN1 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 9.852E-07 | 1.341E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.012E-06 | 1.369E-04 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0032502; developmental process | GO:0007568; aging | 2.296E-06 | 2.793E-04 | AKT1, AURKB, CDK1, CYP1A1, MPO, NOX4, POLB, TP53 |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 2.758E-06 | 3.229E-04 | HIF1A, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 3.161E-06 | 3.608E-04 | AKR1B1, AXL, CDK1, CYP1B1, STAT6 |
Showing 1 to 10 of 70 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 6.145E-08 | 1.510E-06 | CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.269E-04 | 4.198E-04 | CYP1A2; XDH |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.279E-05 | 7.097E-05 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 2.897E-06 | 2.622E-05 | CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 5.830E-08 | 1.510E-06 | CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 3.667E-06 | 3.003E-05 | CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 7.188E-24 | 1.236E-21 | CA12; CA1; CA3; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.393E-04 | 4.356E-04 | CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.118E-04 | 3.866E-04 | CYP2C8; MAOA; CYP1A2; CYP3A4 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.194E-02 | 2.112E-02 | CYP3A4; XDH |
Showing 1 to 10 of 117 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| C00-D49: Neoplasms | Glioma | C71 | KDR |
Showing 1 to 10 of 155 entries