CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.638E-07	1.386E-03	CA1, CA12, CA2, CA4, CA6, CA7, CA9, PTPN1
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	1.019E-06	1.706E-03	PTPN11, PTPN6
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.054E-06	4.156E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	3.054E-06	4.156E-03	CES1, CES2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.682E-21	3.664E-17	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.560E-17	4.965E-13	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.199E-15	1.742E-11	CA1, CA12, CA2, CA4, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	4.807E-21	1.779E-19	CA12; CA1; CA2; CA4; CA7; CA6; CA9; CA14
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.374E-04	4.391E-03	CA2; CA4
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	9.577E-04	1.181E-02	CES2; CES1
hsa04520	Adherens junction_Homo sapiens_hsa04520	2.458E-03	2.273E-02	PTPN1; PTPN6
hsa04931	Insulin resistance_Homo sapiens_hsa04931	5.245E-03	3.881E-02	PTPN1; PTPN11
hsa04650	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	7.935E-03	4.894E-02	PTPN6; PTPN11

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1; ACHE
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	CES1; HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
C00-D49: Neoplasms	Breast cancer	C50	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HSD11B1
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4; HSD11B1
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT; ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4; ACHE
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9; ACHE
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1; ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT; ACHE; ACHE; ACHE
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	CES1
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	CES1
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
C00-D49: Neoplasms	Renal cancer	C64	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	CES1; HSD11B1
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CES1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	CES1
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
NA: NA	Colour dead tissues	NA	PTPN1
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Salvia trijuga

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases