Plant Name: Handroanthus guayacan
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| OPRD1; | |
| AURKB; AURKA; KDR; | |
| CA14; CA7; CA5A; CA6; CA12; CA9; CA5B; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Peptide receptor (family A GPCR) | OPRD1 | Delta opioid receptor | P41143 | CHEMBL236 |
Showing 1 to 10 of 13 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 4.594E-14 | 2.001E-10 | CA12, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 3.274E-16 | 3.564E-12 | CA12, CA14, CA5A, CA5B, CA6, CA7, CA9 |
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 4.177E-06 | 8.268E-03 | AURKA, AURKB |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 5.541E-20 | 1.207E-15 | CA12, CA14, CA5A, CA5B, CA6, CA7, CA9 |
Showing 1 to 4 of 4 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 6.316E-04 | 3.316E-03 | CYP1A1; CYP1B1 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 3.000E-04 | 3.150E-03 | CYP1A1; CYP1B1 |
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.312E-19 | 2.755E-18 | CA12; CA5B; CA5A; CA7; CA6; CA9; CA14 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 9.986E-04 | 4.194E-03 | CYP1A1; CYP1B1 |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 4.694E-04 | 3.286E-03 | CYP1A1; CYP1B1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.258E-03 | 4.402E-03 | CYP1A1; CYP1B1 |
Showing 1 to 6 of 6 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Glioma | C71 | KDR |
| C00-D49: Neoplasms | AML | NA | KDR |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| C00-D49: Neoplasms | Haematological malignancies | C81-C86 | AURKA |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | AURKA |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; KDR; KDR; KDR |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | KDR; KDR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | AURKB; AURKA; CA9; KDR; KDR; KDR |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | AURKB; AURKA |
Showing 1 to 10 of 56 entries